159 patents
Utility
Compositions and methods for treating spinal muscular atrophy
2 Jan 24
In certain aspects, the disclosure provides compositions and methods for treating spinal muscular atrophy.
Ravindra Kumar, Rajasekhar Naga Venkata Sai Suragani, Jia Li
Filed: 2 Apr 18
Utility
ALK7 Binding Proteins and Uses Thereof
28 Dec 23
This disclosure provides ALK7-binding proteins such as anti-ALK7 antibodies, and compositions and methods for making the ALK7-binding proteins.
John Knopf, Jonathan Belk, Nathan J. Sharkey, Ravindra Kumar, Asya Grinberg, Dianne Sako, Roselyne Castonguay, Yossi Dagon
Filed: 20 Jun 23
Utility
Treatments for Hermansky-pudlak Syndrome
14 Dec 23
In certain aspects, the present disclosure relates to methods of treating Hermansky-Pudlak Syndrome (HPS) using a TβRII antagonist.
Rajasekhar Naga Venkata Sai Suragani, Patrick Andre
Filed: 2 Jun 23
Utility
Treatments for Complications Associated with Chronic Liver Disease
14 Dec 23
In certain aspects, the present disclosure relates to methods of treating chronic liver disease, portal hypertension, primary sclerosing cholangitis, and hepatopulmonary syndrome, particularly associated clinical complications such as, for example, pulmonary fibrosis and/or interstitial lung disease (ILD), methods comprising administering TβRII antagonists comprising a heterologous domain and a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand.
Rajasekhar Naga Venkata Sai Suragani, Patrick Andre
Filed: 2 Jun 23
Utility
ALK7:ActRIIB heteromultimers and uses thereof
28 Nov 23
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK7 receptor and an extracellular domain of ActRIIB In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to improve metabolic parameters in a patient in need thereof.
Ravindra Kumar, Asya Grinberg, Dianne Sako, Robert Scott Pearsall, Roselyne Castonguay, Gang Li, Yossi Dagon, John Knopf
Filed: 30 Apr 21
Utility
Methods and compositions for increasing red blood cells
7 Nov 23
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Ravindra Kumar, Rajasekhar Naga Venkata Sai Suragani, John Knopf
Filed: 6 Oct 20
Utility
Compositions and Methods for Treating Pulmonary Hypertension
14 Sep 23
In some aspects, the disclosure relates to BMP antagonists, such as BMP 10 propeptides, and methods of using BMP antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PH-associated complications.
Gang Li, Ravindra Kumar
Filed: 3 Dec 20
Utility
Formulations Comprising Actrii Polypeptide Variants
31 Aug 23
In certain aspects, the present disclosure provides dosing regimens, dosing forms, and formulations comprising a recombinant fusion protein comprising human activin receptor type-II (ActRII) polypeptides or derivatives thereof linked to a constant domain of an immunoglobulin, such as human IgG1 Fc domain.
Robert Steininger
Filed: 4 Nov 21
Utility
Twisted Gastrulation Polypeptides and Uses Thereof
27 Jul 23
In certain aspects, the present invention provides compositions and methods for altering iron metabolism to increase red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
RAJASEKHAR NAGA VENKATA SAI SURAGANI, ASYA GRINBERG, DIANNE SAKO
Filed: 27 Feb 23
Utility
Compositions and Methods for Treating Pulmonary Hypertension
27 Jul 23
In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PH-associated complications.
Ravindra Kumar, John Knopf
Filed: 6 Oct 22
Utility
ALK7 binding proteins and uses thereof
25 Jul 23
This disclosure provides ALK7-binding proteins such as anti-ALK7 antibodies, and compositions and methods for making the ALK7-binding proteins.
John Knopf, Jonathan Belk, Nathan J. Sharkey, Ravindra Kumar, Asya Grinberg, Dianne Sako, Roselyne Castonguay, Yossi Dagon
Filed: 17 Jun 21
Utility
Actrii Proteins for the Treatment of Pulmonary Arterial Hypertension (Pah)
20 Jul 23
In some aspects, the disclosure relates to compositions and methods comprising ActRII polypeptides to treat, prevent, or reduce the progression rate and/or severity of pulmonary arterial hypertension, particularly treating, preventing or reducing the progression rate and/or severity of one or more pulmonary arterial hypertension associated complications.
Janethe de Oliveira Pena, Peter Linde, Sachindra Joshi, Gang Li, Patrick Andre, Ravindra Kumar
Filed: 22 Jun 21
Utility
Activin-actrii Antagonists and Uses for Treating Anemia
11 May 23
Provided herein are methods for the treatment in a subject of anemia, anemia requiring RBC transfusion, low or intermediate- 1 -risk myelodysplastic syndromes (MDS), and/or non-proliferative chronic myelomonocytic leukemia (CMML) in any mammals wherein the methods comprise administration of Activin-ActRII signaling inhibitors to a subject in need of the treatment.
Kenneth M. Attie, Christopher Rovaldi, Abderrahmane Laadem
Filed: 14 Sep 22
Utility
Methods and compositions using GDF15 polypeptides for increasing red blood cells
9 May 23
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Ravindra Kumar, Rajasekhar Naga Venkata Sai Suragani
Filed: 28 Feb 20
Utility
Single-arm Actriia and Actriib Heteromultimers and Methods for Treating Renal Diseases or Conditions
4 May 23
In some aspects, the disclosure relates to single-arm AetRIIA heteromultimers and sing-arm ActRIIB heteromultimers and methods of using such heteromultimers to treat, prevent, or reduce tire progression rate and/or severity of renal diseases or conditions, particularly treating, preventing or reducing the progression rate and/or severity of one or more renal-associated complications.
Gang Li, Ravindra Kumar
Filed: 11 Mar 21
Utility
Compositions and Methods for Treating Pulmonary Hypertension
27 Apr 23
In some aspects, the disclosure relates to ActRII antagonists and methods of using ActRII antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PH-associated complications.
Ravindra Kumar
Filed: 3 Feb 21
Utility
Compositions and methods for treating pulmonary hypertension
11 Apr 23
In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PH-associated complications.
Ravindra Kumar, John Knopf
Filed: 25 Mar 20
Utility
Endoglin peptides to treat fibrotic diseases
28 Feb 23
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a truncated, ligand-binding portion of the extracellular domain of endoglin (ENG) polypeptide may be used to treat fibrotic disorders.
Asya Grinberg, Roselyne Castonguay, Eric Werner, Ravindra Kumar
Filed: 5 Sep 19
Utility
Tgf-beta Superfamily Type I and Type II Receptor Heteromultimers and Uses Thereof
15 Dec 22
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine/threonine kinase receptor of the TGF-beta family and an extracellular domain of a type II serine/threonine kinase receptor of the TGF-beta family.
Ravindra Kumar, Asya Grinberg, Dianne Sako, Robert Scott Pearsall, Roselyne Castonguay
Filed: 18 Nov 20
Utility
Methods for treating vascular eye disorders with ActRII antagonists
13 Dec 22
Disclosed herein are compositions and methods for increasing visual acuity in patients in need thereof and for treating vascular disorders of the eye.
Matthew L. Sherman, Kenneth M. Attie
Filed: 10 Apr 19