74 patents
Page 3 of 4
Utility
Immunomodulator Compounds
25 Feb 21
Christopher LANGE, Viengkham MALATHONG, Darren J. McMURTRIE, Sreenivas PUNNA, Rajinder SINGH, Ju YANG, Penglie ZHANG
Filed: 23 Jan 20
Utility
PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS
25 Feb 21
Pingchen FAN, Rebecca M. LUI, Rajinder SINGH, Venkat Reddy MALI, Yibin ZENG, Penglie ZHANG
Filed: 1 Apr 19
Utility
Indanes As PD-L1 Inhibitors
14 Jan 21
Viengkham MALATHONG, Venkat Reddy MALI, Darren J. McMURTRIE, Sreenivas PUNNA, Howard S. ROTH, Rajinder SINGH, Ju YANG, Penglie ZHANG
Filed: 9 Jul 20
Utility
5-5 FUSED RINGS AS C5a INHIBITORS
14 Jan 21
Pingchen FAN, Christopher W. LANGE, Rebecca M. LUI, Viengkham MALATHONG, Venkat Reddy MALI, Sreenivas PUNNA, Yibin ZENG, Penglie ZHANG
Filed: 4 May 20
Utility
DIARYL SUBSTITUTED 5,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
14 Jan 21
Pingchen FAN, Christopher W. LANGE, Rebecca M. LUI, Viengkham MALATHONG, Venkat Reddy MALI, Sreenivas PUNNA, Rajinder SINGH, Yibin ZENG, Penglie ZHANG
Filed: 27 Jul 20
Utility
Treatment of Focal Segmental Glomerulosclerosis with CCR2 Antagonists
6 Jan 21
Provided herein are methods of treating focal segmental glomerulosclerosis, said methods include administering to a subject in need thereof a therapeutically effective amount of a CCR2 antagonist.
Zhenhua MIAO, Thomas J. SCHALL, Rajinder SINGH
Filed: 10 Aug 20
Utility
Compounds for Treatment of PD-L1 Diseases
6 Jan 21
Viengkham MALATHONG, Pingchen FAN, Christopher LANGE, Venkat Reddy MALI, Darren J. McMURTRIE, Sreenivas PUNNA, Howard S. ROTH, Rajinder SINGH, Ju YANG, Penglie ZHANG
Filed: 18 Jun 20
Utility
Triaryl Compounds for Treatment of PD-L1 Diseases
9 Dec 20
Pingchen FAN, Christopher LANGE, Venkat Reddy MALI, Darren J. McMURTRIE, Viengkham MALATHONG, Sreenivas PUNNA, Rajinder SINGH, Ju YANG, Yibin ZENG, Penglie ZHANG
Filed: 13 May 20
Utility
Indane-amines As PD-L1 Antagonists
2 Dec 20
Christopher LANGE, Sreenivas PUNNA, Rajinder SINGH, Ju YANG, Penglie ZHANG
Filed: 13 Jan 20
Utility
PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS
11 Nov 20
Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.
Pingchen FAN, Jaroslaw KALISIAK, Antoni KRASINSKI, Rebecca M. LUI, Jay POWERS, Sreenivas PUNNA, Hiroko TANAKA, Penglie ZHANG
Filed: 5 Dec 19
Utility
6-5 FUSED RINGS AS C5a INHIBITORS
4 Nov 20
Pingchen FAN, Christopher W. LANGE, Rebecca M. LUI, Viengkham MALATHONG, Venkat Reddy MALI, Sreenivas PUNNA, Rajinder SINGH, Hiroko TANAKA, Yibin ZENG, Penglie ZHANG
Filed: 19 Dec 19
Utility
Method of Treating Focal Segmental Glomerulosclerosis
14 Oct 20
A method of treating focal segmental glomerulosclerosis with a compound of Formula I is provided.
Zhenhua MIAO, Thomas SCHALL, Rajinder SINGH
Filed: 18 Jun 20
Utility
Combination Therapy Using a Chemokine Receptor 2 (CCR2) Antagonist and a PD-1 and/or PD-L1 Inhibitor
23 Sep 20
The present disclosure is drawn to the combination therapy of a Chemokine Receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of a central nervous system cancer.
James J. CAMPBELL, Rajinder SINGH, Samuel HWANG, Xueson WU, Jeffrey K. HARRISON
Filed: 18 Mar 20
Utility
Reducing Tumor Burden by Administering CCR1 Antagonists In Combination with PD-1 Inhibitors or PD-L1 Inhibitors
16 Sep 20
The present invention provides methods for reducing tumor burden, tumor growth, tumor progression, and/or metastasis in a subject suffering from a solid tumor cancer such as triple negative breast cancer.
Israel CHARO, Heiyoun JUNG, Thomas J. SCHALL, Penglie ZHANG
Filed: 13 Jan 20
Utility
Method of Treating Liver Fibrosis
26 Aug 20
A method of treating liver fibrosis with CCR2 antagonists is provided.
Zhenhua Miao, Israel Charo
Filed: 5 May 20
Utility
Compositions and Methods for Treating Inflammatory Bowel Disease Using a Combination Therapy of Small Molecule Inhibitors of C-C Chemokine Receptor Type 9 (CCR9) and ANTI-ALPHA4BETA7 Integrin Blocking Antibodies
26 Aug 20
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof.
James Campbell, Israel CHARO, Thomas SCHALL
Filed: 13 May 20
Utility
SOLUBLE C5aR ANTAGONISTS
19 Aug 20
Pingchen FAN, Antoni KRASINSKI, Venkat Reddy MALI, Shichang MIAO, Sreenivas PUNNA, Yang SONG, Valentino J. STELLA, Yibin ZENG, Penglie ZHANG
Filed: 22 Oct 19
Utility
Aza-Aryl 1H-Pyrazol-yl Benzene Sulfonamides
24 Jun 20
Compounds are provided that act as potent antagonists of the CCR(9) receptor.
Xi CHEN, Junfa FAN, Pingchen FAN, Antoni KRASINSKI, Lianfa LI, Rebecca M. LUI, Jeffrey P. McMAHON, Jay P. POWERS, Yibin ZENG, Penglie ZHANG
Filed: 2 Mar 20
Utility
CXCR7 Inhibitors for the Treatment of Cancer
17 Jun 20
Provided herein are methods of treating cancer in an individual in need thereof, the methods comprising administering to the individual a CXCR7 inhibitor.
Noriko GOTOH, James J. CAMPBELL
Filed: 10 Dec 19
Utility
Methods of Treating Pancreatic Cancer
10 Jun 20
The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
Petrus Bekker, Shichang MIAO, Israel CHARO, Tom SCHALL
Filed: 13 Feb 20