56 patents
Page 2 of 3
Utility
Methods of treating solid tumors with CCR2 antagonists
26 Oct 21
James J. Campbell, Rajinder Singh, Samuel Hwang, Xuesong Wu
Filed: 7 Jan 19
Utility
Substituted anilines as CCR(4) antagonists
12 Oct 21
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
Trevor T. Charvat, Junfa Fan, Christopher W. Lange, Manmohan Reddy Leleti, Yandong Li, Venkat Reddy Mali, Jeffrey P. McMahon, Jay Powers, Sreenivas Punna, Ju Yang
Filed: 30 Jul 19
Utility
Indane-amines as PD-L1 antagonists
5 Oct 21
Christopher Lange, Sreenivas Punna, Rajinder Singh, Ju Yang, Penglie Zhang
Filed: 14 Jan 20
Utility
Methods of treating pancreatic cancer
14 Sep 21
The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
Filed: 14 Feb 20
Utility
CXCR7 antagonists
13 Jul 21
Junfa Fan, Antoni Krasinski, Christopher W. Lange, Rebecca M. Lui, Jeffrey P. McMahon, Jay P. Powers, Yibin Zeng, Penglie Zhang
Filed: 9 Apr 19
Utility
Macrocyclic immunomodulators
13 Jul 21
Viengkham Malathong, Jeffrey McMahon, Darren J. McMurtrie, Sreenivas Punna, Howard S. Roth, Rajinder Singh, Penglie Zhang
Filed: 8 Jul 19
Utility
Compositions and methods for treating inflammatory bowel disease using a combination therapy of small molecule inhibitors of C-C chemokine receptor type 9 (CCR9) and anti-α4β7 integrin blocking antibodies
29 Jun 21
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof.
James Campbell, Israel Charo, Thomas Schall
Filed: 14 May 20
Utility
Inhibitors of CXCR2
22 Jun 21
Xi Chen, Dean R. Dragoli, Junfa Fan, Jaroslaw Kalisiak, Manmohan Reddy Leleti, Viengkham Malathong, Jeffrey McMahon, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang, Venkat Mali
Filed: 12 Jun 19
Utility
Free base crystalline form of a complement component C5a receptor
8 Jun 21
Rajinder Singh, Kwok Yau, Yibin Zeng, Penglie Zhang, Rebecca M. Lui, Antoni Krasinski
Filed: 6 Nov 20
Utility
Compositions and methods for treating inflammatory bowel disease using a combination therapy of small molecule inhibitors of C—C chemokine receptor type 9 (CCR9) and anti-α4β7 integrin blocking antibodies
1 Jun 21
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof.
Yibin Zeng, Penglie Zhang, Thomas Schall, Israel Charo, James J. Campbell
Filed: 9 Dec 19
Utility
Modulators of chemokine receptors
27 Apr 21
Xi Chen, Dean R. Dragoli, Junfa Fan, Jaroslaw Kalisiak, Antoni Krasinski, Manmohan Reddy Leleti, Venkat Mali, Jeffrey McMahon, Rajinder Singh, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang
Filed: 16 May 19
Utility
Method of treating focal segmental glomerulosclerosis
13 Apr 21
A method of treating focal segmental glomerulosclerosis with a compound of Formula I is provided.
Zhenhua Miao, Thomas Schall, Rajinder Singh
Filed: 22 Nov 17
Utility
Immunomodulator compounds
16 Feb 21
Christopher Lange, Viengkham Malathong, Venkat Reddy Mali, Jeffrey McMahon, Darren J. McMurtrie, Sreenivas Punna, Howard S. Roth, Rajinder Singh, Yu Wang, Ju Yang, Penglie Zhang
Filed: 27 Jul 18
Utility
Fused heteroaryl pyridyl and phenyl benzenesuflonamides as CCR2 modulators for the treatment of inflammation
26 Jan 21
Antoni Krasinski, Sreenivas Punna, Solomon Ungashe, Qiang Wang, Yibin Zeng
Filed: 11 Jan 19
Utility
Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
9 Nov 20
Pingchen Fan, Christopher W. Lange, Viengkham Malathong, Venkat Reddy Mali, Sreenivas Punna, Hiroko Tanaka, Yibin Zeng, Penglie Zhang
Filed: 19 Dec 18
Utility
Compositions and methods for treating inflammatory bowel disease using CCR9 inhibitor and anti-TNF-alpha blocking antibodies
5 Oct 20
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof.
Thomas Schall, James J. Campbell
Filed: 12 Jan 20
Utility
CCR6 compounds
28 Sep 20
Daniel Dairaghi, Dean R. Dragoli, Jaroslaw Kalisiak, Christopher W. Lange, Manmohan Reddy Leleti, Yandong Li, Rebecca M. Lui, Venkat Reddy Mali, Viengkham Malathong, Jay P. Powers, Hiroko Tanaka, Joanne Tan, Matthew J. Walters, Ju Yang, Penglie Zhang
Filed: 2 Oct 18
Utility
Diaryl substituted 5,5-fused ring compounds as C5aR inhibitors
31 Aug 20
Pingchen Fan, Christopher W. Lange, Rebecca M. Lui, Viengkham Malathong, Venkat Reddy Mali, Sreenivas Punna, Rajinder Singh, Yibin Zeng, Penglie Zhang
Filed: 19 Dec 18
Utility
Treatment of focal segmental glomerulosclerosis with CCR2 antagonists
31 Aug 20
Zhenhua Miao, Thomas J. Schall, Rajinder Singh
Filed: 9 Oct 18
Utility
2-oxindole compounds
31 Aug 20
Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
Xi Chen, Dean R. Dragoli, Pingchen Fan, Manmohan Reddy Leleti, Rebecca M. Lui, Viengkham Malathong, Jay P. Powers, Rajinder Singh, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang
Filed: 28 Jul 19