36 patents
Utility
2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
16 Jan 24
Ahmad Y. Sheikh, Alessandra Mattei, Xiu C. Wang
Filed: 6 Aug 21
Utility
Biaryl amides with modified sugar groups for treatment of diseases associated with heat shock protein pathway
28 Nov 23
Xin Jiang, Melean Visnick, Christopher F. Bender, Gary Bolton, Bradley Caprathe, Chitase Lee
Filed: 14 May 19
Utility
Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
14 Nov 23
Eric Anderson, Gary L. Bolton, Bradley Caprathe, Xin Jiang, Chitase Lee, William H. Roark, Melean Visnick
Filed: 6 Dec 21
Utility
Methods of Treating COVID-19 Using Bardoxolone Methyl or Analogs Thereof
17 Aug 23
The present invention provides methods of treating patients infected with a coronavirus.
Deborah FERGUSON, W. Christian WIGLEY, Colin MEYER, J. Warren HUFF, Robert M. KRAL, Jr.
Filed: 7 May 21
Utility
C4-MODIFIED Oleanolic Acid Derivatives for Inhibition of IL-17 and Other Uses
10 Aug 23
Melean VISNICK, Xin JIANG, Martha R. HOTEMA, Chitase LEE, Bradley William CAPRATHE, William H. ROARK, Gary L. BOLTON
Filed: 4 Jan 23
Utility
Synthetic Triterpenoids with Nitrogen-based Substituents at C-17 and Methods of Use Thereof
13 Apr 23
Christopher F. BENDER, Ha DO, Xin JIANG, Haizhou SUN, Melean VISNICK, Ingo JANSER, Lloyd J. SIMONS, Heinrich J. SCHOSTAREZ
Filed: 18 Dec 20
Utility
C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses
21 Feb 23
Melean Visnick, Xin Jiang, Martha R. Hotema, Chitase Lee, Bradley William Caprathe, William H. Roark, Gary L. Bolton
Filed: 23 Sep 16
Utility
Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof
20 Sep 22
The present invention provides methods of treating or preventing Alport syndrome in a patients in need thereof using bardoxolone methyl or analogs thereof, and/or improving the kidney function of patients who have been diagnosed with Alport syndrome.
Colin J. Meyer
Filed: 11 Feb 21
Utility
Pyrazolyl and Pyrimidinyl Tricyclic Enones As Antioxidant Inflammation Modulators
8 Sep 22
Eric ANDERSON, Gary L. BOLTON, Bradley CAPRATHE, Xin JIANG, Chitase LEE, William H. ROARK, Melean VISNICK
Filed: 6 Dec 21
Utility
C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
9 Aug 22
Xin Jiang, Christopher F. Bender, Melean Visnick
Filed: 28 Dec 20
Utility
Co-crystal forms of a novobiocin analog and proline
2 Aug 22
Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.
Xin Jiang, John Allen Walling, Melanie J. Bevill, Christopher S. Seadeek, Jared P. Smit
Filed: 5 Jun 20
Utility
Pyrimidine Tricyclic Enone Derivatives for Inhibition of Ror-gamma and Other Uses
5 May 22
Xin JIANG, Christopher F. BENDER, Melean VISNICK, Martha R. HOTEMA, Zachary S. SHELDON, Chitase LEE, Bradley William CAPRATHE, Gary BOLTON, Brian KORNBERG
Filed: 18 Jan 22
Utility
Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
5 Apr 22
Xin Jiang, Christopher F. Bender, Melean Visnick, Martha R. Hotema, Zachary S. Sheldon, Chitase Lee, Bradley William Caprathe, Gary Bolton, Brian Kornberg
Filed: 16 Dec 17
Utility
Antioxidant Inflammation Modulators: Oleanolic Acid Derivatives with Amino and Other Modifications at C-17
27 Jan 22
Eric ANDERSON, Xin JIANG, Melean VISNICK
Filed: 9 Jul 21
Utility
Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
7 Dec 21
Eric Anderson, Gary L. Bolton, Bradley Caprathe, Xin Jiang, Chitase Lee, William H. Roark, Melean Visnick
Filed: 3 Dec 19
Utility
2,2-DIFLUOROPROPIONAMIDE Derivatives of Bardoxolone Methyl, Polymorphic Forms and Methods of Use Thereof
18 Nov 21
Eric ANDERSON, Xiaofeng LIU, Andrea DECKER
Filed: 25 Jun 21
Utility
Pyrazole and Imidazole Compounds for Inhibition of IL-17 and Rorgamma
23 Sep 21
Xin JIANG, Melean VISNICK, Christopher F. BENDER, Gary BOLTON, Bradley CAPRATHE, Chitase LEE, Brian KORNBERG, Patrick O'BRIEN, Martha R. HOTEMA
Filed: 17 Jun 19
Utility
Biaryl Amides with Modified Sugar Groups for Treatment of Diseases Associated with Heat Shock Protein Pathway
26 Aug 21
Xin JIANG, Melean VISNICK, Christopher F. BENDER, Gary BOLTON, Bradley CAPRATHE, Chitase LEE
Filed: 14 May 19
Utility
Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
17 Aug 21
Eric Anderson, Xin Jiang, Melean Visnick
Filed: 10 Feb 20
Utility
2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
3 Aug 21
Eric Anderson, Xiaofeng Liu, Andrea Decker
Filed: 14 Jun 17