45 patents
Page 2 of 3
Utility
Echo-based Focusing Correction
10 Feb 22
Various approaches for focusing an ultrasound transducer include introducing at least one transient acoustic reflector located in proximity to at least one target region; generating multiple sonications to the at least one target region; measuring a reflection signal of each of the sonications off the at least one transient acoustic reflector; selecting the measured reflection signals, and based at least in part on the selected reflection signals, adjusting a parameter value associated with at least one of the transducer elements so as to improve an ultrasound focus at the target region.
Oleg PRUS, Yoav LEVY
Filed: 18 Dec 19
Utility
3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
21 Sep 21
An approach for enhancing radiation treatment of target tissue includes identifying a target volume of the target tissue; causing disruption of vascular tissue in a region confined to the target volume so as to define the target volume; based at least in part on the disruption of the vascular tissue, determining a radiation treatment plan having a reduced radiation dose for treating the target tissue; and exposing the target volume to the reduced radiation dose based on the radiation treatment plan.
Kobi Vortman, Yoav Levy
Filed: 29 Jun 17
Utility
Systems and methods for avoiding MRI-originated interference with concurrently used systems
7 Sep 21
MRI interference with a concurrently operated system may be reduced or corrected by subtracting the MRI interference from signals measured using the concurrently operated system.
Benny Assif
Filed: 15 Oct 15
Utility
Overcoming acoustic field and skull non-uniformities
31 Aug 21
Various approaches for heating a target region substantially uniformly include identifying one or more locations of one or more hot spots in the target region and/or surrounding regions of the target region during an ultrasound sonication process; computing a temporal variation to an output parameter of at least one of the transducer elements based at least in part on the identified location(s) of the hot spot(s); and operating the at least one transducer element to achieve the temporal variation of the output parameter so as to minimize the hot spot(s).
Kobi Vortman, Shuki Vitek, Eyal Zadicario, Yoav Levy
Filed: 12 Jan 17
Utility
Focused Ultrasound System with Optimized Monitoring of Cavitation
8 Jul 21
Various approaches for generating an ultrasound focus at a target region and receiving signals therefrom using an ultrasound transducer having multiple transducer elements include acquiring multiple images of the target region and one or more path zones located on beam paths between the transducer elements and the target region; determining one or more tissue characteristics associated with the target region based on the acquired images; determining multiple profile parameters associated with each of the transducer elements based at least in part on the determined tissue characteristic; based at least in part on the profile parameters, operating at least first ones of the transducer elements to collectively transmit an ultrasound beam to the target region so as to create a focus thereon with desired properties; and based at least in part on the profile parameters, operating at least second ones of the transducer elements to receive acoustic signals from the target region and, in response thereto, adjusting operation of the at least first ones of the transducer elements to thereby improve the focus at the target region.
Kobi VORTMAN, Rafi DE PICCIOTTO
Filed: 4 Jun 19
Utility
Controlling Delivery of Therapeutic Agent In Microbubble-enhanced Ultrasound Procedures
24 Jun 21
Various approaches for microbubble-enhanced ultrasound treatment of target tissue include receiving a desired characteristic of the microbubbles for treating the target tissue; causing the microbubbles to be dispensed from the administration device; and comparing a characteristic of the dispensed microbubbles to the desired characteristic so as to validate a match therebetween.
Eyal ZADICARIO, Yoav LEVY
Filed: 5 Dec 18
Utility
Adaptive, Closed-loop Ultrasound Therapy
10 Jun 21
Various approaches to focusing an ultrasound transducer includes causing the ultrasound transducer to transmit ultrasound waves to the target region; causing the detection system to indirectly measure the focusing properties; and based at least in part on the indirectly measured focusing properties, adjusting a parameter value associated with at least one of the transducer elements so as to achieve a target treatment power at the target region.
Kobi VORTMAN, Yoav LEVY, Oleg PRUS, Shuki VITEK
Filed: 5 Dec 18
Utility
Cavitation-enhanced Targeted Drug Delivery and Dosing
20 May 21
Various approaches for disrupting target tissue for treatment include identifying a target volume of the target tissue; causing disruption of the target tissue in a region corresponding to the target volume so as to increase tissue permeability therein; computationally generating a tissue permeability map of the target volume; and based on the tissue permeability map, computationally evaluating the disruption of the target tissue within the target volume.
Yoav LEVY, Kobi VORTMAN
Filed: 29 Jun 18
Utility
Phased array calibration for geometry and aberration correction
26 Jan 21
Various approaches for calibrating the geometry of an ultrasound transducer having multiple transducer elements include providing an acoustic reflector spanning an area traversing by multiple beam paths of ultrasound waves transmitted from all (or at least some) transducer elements to a focal zone; causing the transducer elements to transmit the ultrasound waves to the focal zone; measuring reflections of the ultrasound waves off the acoustic reflector; and based at least in part on the measured reflections, determining optimal geometric parameters associated with the transducer elements.
Oleg Prus, Yoav Levy
Filed: 18 May 20
Utility
Systems and methods for avoiding MRI-originated interference with concurrently used systems
28 Dec 20
MRI interference with a concurrently operated system may be reduced or corrected by subtracting the MRI interference from signals measured using the concurrently operated system.
Benny Assif
Filed: 14 Oct 15
Utility
Systems and methods for registering images obtained using various imaging modalities and verifying image registration
28 Dec 20
Embodiments of the present invention provide systems and methods to detect a moving anatomic feature during a treatment sequence based on a computed and/or a measured shortest distance between the anatomic feature and at least a portion of an imaging system.
Omer Brokman, Oleg Prus, Eyal Zadicario
Filed: 15 May 16
Utility
Control of Exogenous Agent Characteristics In Microbubble-mediated Ultrasound Procedures
16 Dec 20
Various approaches for microbubble-enhanced ultrasound treatment of target tissue include retrieving a treatment plan stored in memory; causing administration of an exogenous agent in accordance with the treatment plan; causing, in accordance with the treatment plan, an ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent; receiving, from a monitoring system, a measured parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment; and adjusting the treatment plan based at least in part on the measured parameter value.
Yoav Levy
Filed: 10 Dec 18
Utility
Systems and methods for optimizing transcranial ultrasound focusing
7 Sep 20
Systems and methods for predicting a phase correction of ultrasound waves transmitted from one or more transducer elements and traversing a patient's skull into a target region utilizing data of the patient's skull include predicting a first beam path of the ultrasound waves traversing the skull based at least in part on the target location; computationally determining structural characteristics of the skull along the first beam path based on the acquired imaging data; and predicting a second beam path of the ultrasound waves traversing the skull based at least in part on the determined structural characteristics, thereby accounting for refraction resulting from the skull.
Shuki Vitek, Yoav Levy
Filed: 4 Jun 17
Utility
Simulation-based focused-ultrasound treatment planning
24 Aug 20
A focused-ultrasound or other procedure for treating a target within a tissue region can be planned iteratively by creating a treatment plan specifying a treatment location pattern and stimuli applied thereto, simulating the treatment, computationally predicting an effect of the simulated treatment, comparing the predicted effect against one or more treatment constraints (such as efficacy and/or safety thresholds), and, if a constraint is violated, repeating the simulation for an adjusted treatment plan.
Yoav Levy, Benny Assif, Gilad Halevy, Yoni Hertzberg
Filed: 28 Jan 14
Utility
Phased array calibration for geometry and aberration correction
10 Aug 20
Various approaches for calibrating the geometry of an ultrasound transducer having multiple transducer elements include providing an acoustic reflector spanning an area traversing by multiple beam paths of ultrasound waves transmitted from all (or at least some) transducer elements to a focal zone; causing the transducer elements to transmit the ultrasound waves to the focal zone; measuring reflections of the ultrasound waves off the acoustic reflector; and based at least in part on the measured reflections, determining optimal geometric parameters associated with the transducer elements.
Oleg Prus, Yoav Levy
Filed: 10 Dec 17
Utility
Systems and Methods for Ensuring Coherence Between Multiple Ultrasound Transducer Arrays
10 Jun 20
A system for maintaining coherence of ultrasound waves emitted by multiple transducer arrays includes multiple retention arms, each for receiving one of the transducer arrays; a connecting frame for receiving and mechanically retaining the arms in fixed angular relation to each other; and a processor configured to determine relative locations of the transducer arrays with respect to one another and the connecting frame; determine a location of the connecting frame relative to an anatomic region of interest; determine a spatial arrangement of the transducer elements in each transducer array with respect to the anatomic region of interest; and adjust a transmission configuration of the transducer elements in the transducer arrays to achieve a desired focusing property with respect to the anatomic region of interest while maintaining coherence therebetween.
Yoav LEVY
Filed: 19 Jun 17
Utility
Systems and methods for correcting measurement artifacts in MR thermometry
8 Jun 20
Systems and methods for performing magnetic resonance (MR) thermometry include a magnetic resonance imaging (MRI) unit and a controller in communication with the MRI unit and configured to cause the MRI unit to acquire one or more baseline phase images of an imaging region and one or more treatment phase images of the imaging region subsequent to a temperature change of a subregion within the imaging region, electronically generate a thermal map pixelwise indicating the temperature change of the subregion based at least in part on the acquired baseline phase image and treatment phase image, computationally predict the temperature change of the subregion based at least in part on energy deposited in the subregion during treatment without reference to the generated thermal map, and determine whether the thermal map is inaccurate based at least in part on the temperature change of the subregion indicated by the thermal map and the predicted temperature change of the subregion.
Shahar Rinott, Yoav Levy
Filed: 27 Nov 18
Utility
Systems and Methods for Selective, Targeted Opening of the Blood-brain Barrier
6 May 20
Systems and methods for applying ultrasound sonication to temporarily disrupt a patient's blood-brain barrier (BBB) include storing threshold values of an acoustic response level, an acoustic response dose and a tissue response dose associated with a target BBB region and its surrounding regions based on anatomical characteristics thereof; causing the ultrasound transducer to transmit one or more pulses/waves; measuring the acoustic response level, the acoustic response dose, and/or the tissue response dose associated with the target BBB region and/or its surrounding regions; comparing the measurement with a corresponding stored threshold value; and operating the transducer based at least in part on the comparison.
Yoav LEVY, Eyal ZADICARIO, Javier GRINFELD, Rafi DE PICCIOTTO
Filed: 21 May 18
Utility
Therapeutic ultrasound with reduced interference from microbubbles
16 Mar 20
Various approaches for reducing microbubble interference with ultrasound waves transmitted from multiple transducer elements and traversing tissue onto a target region include measuring microbubbles in high-throughput areas of ultrasound exposure and reducing the amount of microbubbles using the ultrasound waves.
Kobi Vortman, Shuki Vitek, Eyal Zadicario, Yoav Levy
Filed: 13 Sep 16
Utility
Cavitation localization
2 Mar 20
Various approaches for detecting microbubble cavitation resulting from ultrasound waves transmitted from an ultrasound transducer include associating at least one time-domain reference signal with microbubble cavitation; causing the transducer to transmit one or more ultrasound pulse; acquiring, in the time domain, an echo signal from microbubbles in response to the transmitted ultrasound pulse(s); correlating at least a portion of the echo signal to at least a corresponding portion of the time-domain reference signal based on similarity therebetween; and detecting the microbubble cavitation based on the corresponding portion of the reference signal.
Oleg Prus, Yoav Levy
Filed: 24 Jan 17