Flagship Pioneering USPTO patents

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Adipogenic Cell Compositions and Methods

11 Jan 24

Disclosed herein are compositions comprising adipogenic cells that are useful for the treatment, prevention, or amelioration of diseases or disorders.

Alexandra Sophie DE BOER, Le Phuan Lizzie NGO, Avak KAHVEJIAN, Jordan LEWANDOWSKI

Filed: 24 Nov 21

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Bifunctional Molecules and Methods of Using Thereof

19 Oct 23

The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid sequence and a second domain that specifically binds to a target protein, and uses thereof.

Nathan Wilson STEBBINS, Benjamin Andrew PORTNEY, Eric Bruno VALEUR, Chih-Chi Yuan, Mitchell Guttman

Filed: 24 Mar 21

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27 Jul 23

Anti-viral compounds and methods of using antiviral compounds are described.

Hok Hei Tam, David Barry Kolesky

Filed: 23 Jun 21

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29 Jun 23

The disclosure provides compositions and methods for generating polyclonal antibodies, for example, using circular polyribonucleotides and non-human animals having humanized immune systems.

Alexandra Sophie DE BOER, Avak KAHVEJIAN, Frances Marion Nicole ANASTASSACOS, Jennifer A. NELSON, Nicholas McCartney PLUGIS, Roger Joseph HAJJAR, Yann Paul Guy Régis ECHELARD

Filed: 20 May 21

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25 May 23

The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid and a second domain that specifically binds to a target polypeptide, and uses thereof.

Nathan Wilson STEBBINS, Benjamin Andrew PORTNEY, Eric Bruno VALEUR, Jacob Rosenblum RUBENS, Kaveh DANESHVAR, Alexandra Rachael SNEIDER

Filed: 21 Apr 21

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17 Nov 22

The disclosure relates generally to methods of modifying a nucleic acid sequence, systems for modifying a nucleic acid sequence, and compositions made by said methods or systems.

Christine Elizabeth Hajdin, David Arthur Berry, Theonie Anastassiadis, Noubar Boghos Afeyan

Filed: 4 Nov 20

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17 Nov 22

The invention relates generally to uses of tRNA-based effector molecules (TREMs) corresponding to con-rare codons and methods of making the same.

Christine Elizabeth Hajdin, David Arthur Berry, Theonie Anastassiadis, Noubar Boghos Afeyan

Filed: 4 Nov 20

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21 Jul 22

The invention relates generally to uses of tRNA-based effector molecules (TREMs) and methods of making the same.

David Arthur Berry, Theonie Anastassiadis, Christine Elizabeth Hajdin, Noubar Boghos Afeyan

Filed: 29 May 20

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14 Apr 22

The invention relates generally to tRNA-based effector molecules and methods relating thereto.

David Arthur Berry, Theonie Anastassiadis, Noubar Boghos Afeyan, Christine Elizabeth Hajdin

Filed: 17 Jan 20

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30 Sep 20

Therapeutic chondrisome and mitoplast compositions and related methods are described.

Geoffrey von Maltzahn, John Miles Milwid, Michael Mee, Jacob Rosenblum Rubens, David Chess, Kyle Trudeau, Kiana Mahdaviani, Jacob Feala

Filed: 29 Nov 16

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8 Apr 20

Methods and compositions for modulating a target genome are disclosed.

Jacob Rosenblum Rubens, Geoffrey A. von Maltzahn, Robert James Citorik, Barrett Ethan Steinberg, Donghui Li

Filed: 5 Dec 19