79 patents
Page 4 of 4
Utility
Deuterated CFTR Modulators and Methods of Use
22 Apr 20
Vincent S. Chan, Philip R. Kym, Shashank Shekhar, Xueqing Wang
Filed: 18 Dec 17
Utility
Heteroaryl substituted pyridines and methods of use
30 Mar 20
Robert J. Altenbach, Andrew Bogdan, Ghjuvanni Petru Diunisu Coti, Marlon D. Cowart, Stephen N. Greszler, Hans Kelgtermans, Philip R. Kym, Steven Emiel Van der Plas, Xueqing Wang
Filed: 18 Oct 18
Utility
Antagonists of IL-17C for the treatment and/or prevention of atopic dermatitis
30 Mar 20
The present invention provides antagonists of IL-17C for use in the treatment and/or prevention of atopic dermatitis and related conditions.
Nick Ernest René Vandeghinste, Reginald Christophe Xavier Brys
Filed: 4 Oct 16
Utility
Novel Compound Useful for the Treatment of Degenerative and Inflammatory Diseases
11 Mar 20
A novel compound able to inhibit JAK is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
Christel Jeanne Marie MENET, Koen Kurt Smits
Filed: 8 May 19
Utility
Compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis
24 Feb 20
Steven Emiel Van der Plas, Hans Kelgtermans, Sébastien Jean Jacques Cédric Dropsit Montovert, Sébastien Laurent Xavier Martina, Martin James Inglis Andrews
Filed: 8 Jan 18
Utility
Dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
24 Feb 20
Christel Jeanne Marie Menet, Julien Georges Pierre-Olivier Doyon, Pieter Isabelle Roger Claes, Brigitte Allart, Maxim Maria Paul De Wachter, Giovanni Alessandro Tricarico
Filed: 18 Apr 16
Utility
5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis
3 Feb 20
Frédéric Gilbert Labéguère, Rama Heng, Frédéric André De Ceuninck, Luke Jonathan Alvey, David Amantini, Franck Laurent Brebion, Pierre Marc Marie Joseph Deprez, Romain Luc Marie Gosmini, Hélène Marie Jary, Christophe Peixoto, Iuliana Ecaterina Pop-Botez, Marie Laurence Claire Varin
Filed: 31 May 17
Utility
Antibodies for IL-17C
8 Jan 20
The present invention provides antibodies or antibody fragments binding to human IL-17C.
Jürgen Klattig, Nick Ernest René Vandeghinste, Teresa Auf Der Garcia
Filed: 4 Aug 19
Utility
Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
6 Jan 20
Nicolas Desroy, Bertrand Heckmann, Reginald Christophe Xavier Brys, Agnès Marie Joncour, Christophe Peixoto, Xavier Marie Bock
Filed: 27 Sep 18
Utility
Novel Compounds and Pharmaceutical Compositions Thereof for the Treatment of Fibrosis
25 Dec 19
Oscar MAMMOLITI, Koen Karel JANSEN, Adeline Marie Elise PALISSE, Caroline Martine Andrée Marie JOANNESSE, Christel Jeanne Marie MENET, Brigitte ALLART, Sandy EL BKASSINY
Filed: 22 Feb 17
Utility
6-[5-amino-6-(2-ethoxyethoxy)-imidazo[4,5-B]pyridin-3-yl]-nicotinonitrile derivatives and their use as IRAK inhibitors
16 Dec 19
Reginald Christophe Xavier Brys, Raphaël Jean Joël Geney, Agnès Marie Joncour, Julien Georges Pierre-Olivier Doyon, Frédéric Gilbert Labéguère, Jean-Michel Lefrançois, Oscar Mammoliti, Benoît Antoine Schmitt, Steven Emiel Van Der Plas, Christel Jeanne Marie Menet
Filed: 13 Oct 16
Utility
Pharmaceutical compositions for the treatment of inflammatory disorders
2 Dec 19
Marc Maurice Germain De Weer, Sara Bertha Camiel Vrielynck, Nicolas Luc Sabourault, Jan Peter Moeschwitzer
Filed: 3 Feb 15
Utility
5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis
25 Nov 19
Franck Laurent Brebion, Luke Jonathan Alvey, David Amantini, Frédéric André De Ceuninck, Pierre Marc Marie Joseph Deprez, Romain Luc Marie Gosmini, Hélène Marie Jary, Christophe Peixoto, Iuliana Ecaterina Pop-Botez, Marie Laurence Claire Varin
Filed: 13 Feb 18
Utility
N-Sulfonylated-Pyrazolo[3,4-b]Pyridin-6-Carboxamides and Method of Use
30 Oct 19
Rhalid Akkari, Luke Jonathan Alvey, Xavier Marie Bock, Brian S. Brown, Pieter Isabelle Roger Claes, Marlon D. Cowart, Elsa De Lemos, Nicolas Desroy, Béranger Duthion, Gregory A. Gfesser, Romain Luc Marie Gosmini, Christopher Gaëtan Housseman, Koen Karel Jansen, Jianguo Ji, Philip R. Kym, Jean-Michel Lefrancois, Oscar Mammoliti, Christel Jeanne Marie Menet, Nuria Merayo Merayo, Gregory John Robert Newsome, Adeline Marie Elise Palisse, Sachin V. Patel, Matthieu Rafaël Pizzonero, Anurupa Shrestha, Elizabeth C. Swift, Steven Emiel Van der Plas, Xueqing Wang, Ann de Blieck
Filed: 17 Jun 19
Utility
Compounds and Pharmaceutical Compositions Thereof for the Treatment of Inflammatory Diseases
16 Oct 19
The present invention relates to the use of compounds or pharmaceutical compositions comprising the same, and methods of treatment using the same, in the prophylaxis and/or treatment of alopecia areata, vitiligo, cutaneous lupus, lupus nephritis, giant cell arteritis, sarcoïdosis and/or sarcoïdosis-related conditions.
Chantal Thérèse TASSET, Pille HARRISON, René Alexandre GALIEN, John Sargent SUNDY, John G. MCHUTCHISON, Thomas O'RIORDAN, Neelufar MOZAFFARIAN, Uptal Dinesh PATEL, Timothy R. WATKINS, David L. GOSSAGE
Filed: 8 Nov 17
Utility
Substituted Pyrrolidines and Methods of Use
16 Oct 19
Robert J. Altenbach, Andrew Bogdan, Nicolas Desroy, Gregory A. Gfesser, Stephen N. Greszler, John R. Koenig, Philip R. Kym, Bo Liu, Marc J. Scanio, Xenia B. Searle, Xueqing Wang, Ming C. Yeung, Gang Zhao
Filed: 13 Jun 19
Utility
5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE Derivatives As Adamts 4 and 5 Inhibitors for Treating E.g. Osteoarthritis
16 Oct 19
Frédéric Gilbert LABÉGUÈRE, Rama HENG, Frédéric André DE CEUNINCK, Luke Jonathan ALVEY, David AMANTINI, Franck Laurent BREBION, Pierre Marc Marie Joseph DEPREZ, Romain Luc Marie GOSMINI, Hélène Marie JARY, Christophe PEIXOTO, Iuliana Ecaterina POP-BOTEZ, Marie Laurence Claire VARIN
Filed: 31 May 17
Utility
5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE Derivatives As Adamts 4 and 5 Inhibitors for Treating E.g. Osteoarthritis
2 Oct 19
Frédéric Gilbert LABÉGUÈRE, Rama HENG, Frédéric André DE CEUNINCK, Luke Jonathan ALVEY, David AMANTINI, Franck Laurent BREBION, Pierre Marc Marie Joseph DEPREZ, Romain Luc Marie GOSMINI, Hélène Marie JARY, Christophe PEIXOTO, Iuliana Ecaterina POP-BOTEZ, Marie Laurence Claire VARIN
Filed: 31 May 17
Utility
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
30 Sep 19
The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Robert J. Altenbach, Andrew Bogdan, Nicolas Desroy, Gregory A. Gfesser, Stephen N. Greszler, Philip R. Kym, Bo Liu, Karine Fabienne Malagu, Nuria Merayo Merayo, Mathieu Rafaël Pizzonero, Xenia B. Searle, Steven Emiel Van der Plas, Xueqing Wang, Ming C. Yeung, Gang Zhao
Filed: 21 Feb 18