36 patents
Utility
Treatment of Hematological Malignancies with Inhibitors of Menin
21 Dec 23
The present disclosure provides methods for treating hematological malignancies using menin inhibitors.
Francis BURROWS, Blake TOMKINSON
Filed: 19 Oct 21
Utility
Macrocyclic Compounds and Compositions, and Methods of Preparing and Using the Same
12 Oct 23
The present invention relates to macrocyclic compounds of any one of Formula (I), or a pharmaceutically acceptable form thereof, pharmaceutical compositions comprising the same, methods of preparing the same, and methods of treating cancer dependent on a farnesylated protein, using the same.
Xuefeng Zhu, Pingda Ren, Zhu Bai, Wanting Xiong, Dan Xu, Yahu Arthur Liu
Filed: 5 Jun 23
Reissue
Thienopyrimidine and thienopyridine compounds and methods of use thereof
10 Oct 23
The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but not limited to MLL1, MLL2 and MLL-fusion oncoproteins.
Jolanta Grembecka, Tomasz Cierpicki, Dmitry Borkin, Jonathan Pollock, Hongzhi Miao, Duxin Sun, Liansheng Li, Tao Wu, Jun Feng, Pingda Ren, Yi Liu
Filed: 2 Feb 21
Utility
Methods of Treating Squamous Cell Carcinomas with Farnesyltransferase Inhibitors
10 Aug 23
The present invention relates to the field of cancer therapy.
Francis Burrows, Yi Liu
Filed: 14 Apr 23
Utility
Substituted inhibitors of menin-MLL and methods of use
16 May 23
The present disclosure provides methods of inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
Tao Wu, Liansheng Li, Pingda Ren
Filed: 19 Sep 18
Utility
Treatment of Hematological Malignancies with Inhibitors of Menin
30 Mar 23
The present disclosure provides methods for treating hematological malignancies using menin inhibitors.
Francis BURROWS
Filed: 26 Sep 19
Utility
Methods of Treating Cancer Patients with Farnesyltransferase Inhibitors
23 Mar 23
The present invention relates to the field of molecular biology and cancer biology.
Antonio Gualberto, Catherine Rose Scholz
Filed: 31 May 22
Utility
Methods for Treating Hematological Malignancies and Ewing's Sarcoma
26 Jan 23
The present disclosure provides methods for treating hematological malignancies and Ewings sarcoma using menin inhibitors.
Francis BURROWS, Linda V. KESSLER, Liansheng LI, Pingda REN, Yi WANG, Tao WU, Jingchuan ZHANG, I
Filed: 22 Mar 18
Utility
Bridged bicyclic inhibitors of menin-MLL and methods of use
17 Jan 23
Tao Wu, Liansheng Li, Yi Wang, Pingda Ren, Jolanta Grembecka, Tomasz Cierpicki, Szymon Klossowski, Jonathan Pollock, Dmitry Borkin
Filed: 13 Jul 20
Utility
Methods of treating cancer with farnesyltransferase inhibitors
3 Jan 23
The present invention relates to the field of cancer therapy.
Antonio Gualberto, Catherine Rose Scholz
Filed: 21 Feb 18
Utility
Methods and compositions for inhibiting the interaction of menin with MLL proteins
3 Jan 23
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
Liansheng Li, Tao Wu, Jun Feng, Pingda Ren, Yi Liu, Jolanta Grembecka, Tomasz Cierpicki, Dmitry Borkin, Jonathan Pollock
Filed: 7 Jun 18
Utility
Synthesis of tipifarnib
3 Jan 23
Provided herein are methods of preparing a desired enantiomer 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone, otherwise known as tipifarnib.
Pingda Ren, Xiaohu Deng, Wanping Mai
Filed: 17 May 19
Utility
Methods of Treating Acute Myeloid Leukemia with Farnesyltransferase Inhibitors
29 Sep 22
The present invention relates to the field of cancer therapy.
Antonio Gualberto
Filed: 1 May 20
Utility
Methods of Treating Cancer with Farnesyltransferase Inhibitors
2 Jun 22
The present invention relates to the field of cancer therapy.
Antonio Gualberto
Filed: 26 Mar 20
Utility
Methods of Treating Cancer with Farnesyltransferase Inhibitors
12 May 22
The present invention relates to the field of cancer therapy.
Antonio Gualberto
Filed: 28 Feb 20
Utility
Methods of Treating Cancer with Farnesyltransferase Inhibitors
12 May 22
The present invention relates to the field of molecular biology and cancer biology.
Antonio Gualberto
Filed: 12 Mar 20
Utility
Methods of Treating Squamous Cell Carcinomas with Farnesyltransferase Inhibitors
21 Apr 22
The present invention relates to the field of cancer therapy.
Francis Burrows, Yi Liu
Filed: 28 Sep 21
Utility
Methods of treating cancer with farnesyltransferase inhibitors
5 Apr 22
The present invention relates to the field of cancer therapy.
Antonio Gualberto
Filed: 7 Aug 18
Utility
Therapies for Squamous Cell Carcinomas
10 Mar 22
The present invention relates to the field of cancer therapy.
Antonio Gualberto, Catherine Rose Scholz, Vishnu S. Mishra
Filed: 20 Dec 19
Utility
Methods of Treating Cancer with Farnesyltransferase Inhibitors
6 Jan 22
The present invention relates to the field of cancer therapy.
Antonio Gualberto
Filed: 31 Oct 19