1063 patents
Page 12 of 54
Utility
Antibodies Against CD73 and Uses Thereof
16 Feb 23
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization.
Nils Lonberg, Alan J. Korman, Bryan C. Barnhart, Aaron P. Yamniuk, Mohan Srinivasan, Karla A. Henning, Ming Lei, Emanuela Sega, Angela Goodenough, Maria N. Jure-Kunkel, Guodong Chen, John S. Sack, Richard Huang, Martin J. Corbett, Joseph E. Myers, JR., Liang Schweizer, Sandra V. Hatcher, Haichun Huang, Pingping Zhang
Filed: 5 May 22
Utility
Salts/cocrystals of (R)-N-(4-CHLOROPHENYL)-2-((1S,4S)-4-(6-FLUOROQUINOLIN-4-YL)CYCLOHEXYL)PROPANAMIDE
16 Feb 23
The present disclosure relates to amorphous and crystalline forms of (R)—N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl)cyclohexyl)propanamide and its salts/cocrystals, solvates, and/or hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.
Tamar I. ROSENBAUM, Melanie Janelle BEVILL
Filed: 23 Nov 20
Utility
Handheld medicament dispenser
14 Feb 23
The present invention relates to a hand-held medicament dispenser.
Brandon J. Pollack, Michael P. Stolz
Filed: 27 Aug 19
Utility
Compounds useful as immunomodulators
14 Feb 23
The present disclosure generally relates to compounds useful as immunomodulators.
Kap-Sun Yeung, Denis R. St. Laurent, David R. Langley, Paul Michael Scola
Filed: 28 Feb 19
Utility
1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
9 Feb 23
Yam B. POUDEL, Matthew COX, Liqi HE, Ashvinikumar V. GAVAI, Sanjeev GANGWAR, Mathias BROEKEMA, Christine M. TARBY, Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH
Filed: 26 Jan 21
Utility
Human Monoclonal Antibodies Against Interleukin 8 (IL-8)
9 Feb 23
Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed.
Jessica TEELING, Paul PARREN, Ole BAADSGAARD, Debra HUDSON, Jørgen PETERSEN
Filed: 22 Apr 22
Utility
Biarylmethyl Heterocycles
9 Feb 23
Eldon Scott PRIESTLEY, Samuel Kaye REZNIK, Edward H. RUEDIGER, James R. GILLARD, Oz Scott HALPERN, Wen JIANG, Jeremy RICHTER, Rejean RUEL, Sasmita TRIPATHY, Wu YANG, Xiaojun ZHANG
Filed: 11 Jul 22
Utility
Combinatorial Drug Delivery Device
9 Feb 23
In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components.
Martin John McLoughlin, Chester Larrow, Mariano Mumpower
Filed: 26 Oct 22
Utility
Substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
7 Feb 23
Improved methods and intermediates thereof for preparing substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds are described.
Sha Lou, Adrian Ortiz, Christopher Robert Jamison, Victor W. Rosso, Mansi S. Shah
Filed: 15 Aug 19
Utility
Broadly neutralizing anti-HIV-1 antibodies that bind to an N-glycan epitope on the envelope
7 Feb 23
This invention relates to novel anti-HIV antibodies that can be used in the treatment and detection of human immunodeficiency virus (HIV).
Francois Vigneault, Adrian Wrangham Briggs, Stephen J. Goldfless, Sonia Timberlake
Filed: 2 Sep 20
Utility
Combination therapy with anti-IL-8 antibodies and anti-PD-1 antibodies for treating cancer
7 Feb 23
Provided herein are methods for the clinical treatment of tumors (e.g., advanced solid tumors) in patients having certain levels of serum IL-8 using an anti-IL-8 antibody in combination with an anti-PD-1 antibody.
Michael Carleton, David Feltquate, Olivier De Henau, Timothy Patrick Reilly, Tian Chen, Ye Feng, Shu-Pang Ben Huang, Ming Zhou, Ramachandran Suresh
Filed: 11 Jan 19
Utility
Process for the preparation of bromodomain inhibitor
31 Jan 23
The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof.
John Fitzgerald Traverse, Kelvin Hin-Yeong Yong, Antonio Christian Ferretti, Hekla Alite, Jonathan Moseley, Antonio Maria Ruda, David Primer, Steven Philp
Filed: 23 Jul 19
Utility
Methods of treating a tumor using an anti-PD-1 antibody
31 Jan 23
This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity.
Robin Edwards, William J. Geese, Danielle M. Greenawalt
Filed: 1 Jun 18
Utility
Anti-CSF1R antibody and anti-PD-1 antibody combination therapy for selected cancers
31 Jan 23
Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
Brian Wong, Julie Hambleton, Robert Sikorski, Emma Masteller, Kevin Hestir, David Bellovin, Katherine E. Lewis
Filed: 4 Mar 20
Utility
Label-free N-glycan Quantification Methods
26 Jan 23
This disclosure provides a novel label-free N-glycan analysis method to detect and quantify N-glycans and N-linked glycosylation profiles without using a label, such as a fluorescent label.
Letha CHEMMALIL, Julia DING, Zhengjian LI
Filed: 23 Nov 20
Utility
Immunomodulators
26 Jan 23
Tao WANG, Paul Michael SCOLA, Zhongxing ZHANG
Filed: 19 Nov 20
Utility
BISFLUOROALKYL-1,4-BENZODIAZEPINONE Compounds for Treating Desmoid Tumors
19 Jan 23
Bruce S. FISCHER, Gaurav Bajaj, Matti Davis, Joel Kaye
Filed: 12 Sep 22
Utility
Amide-substituted Heterocyclic Compounds for the Treatment of Conditions Related to the Modulation of IL-12, IL-23 And/or Ifn-alpha
19 Jan 23
Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
Steven H. Spergel, William J. Pitts, Michael E. Mertzman, Ryan M. Moslin, Trevor C. Sherwood, John L. Gilmore, Alaric J. Dyckman
Filed: 28 Oct 19
Utility
1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
17 Jan 23
Yam B. Poudel, Sanjeev Gangwar, Liqi He, Prasanna Sivaprakasam, Matthias Broekema, Matthew Cox, Christine M. Tarby, Qian Zhang, Naidu S. Chowdari
Filed: 31 Jul 19
Utility
Compounds useful as inhibitors of helios protein
10 Jan 23
Andrew P. Degnan, Godwin Kwame Kumi, Audris Huang, James Aaron Balog, Ashok Vinayak Purandare, Weifang Shan, Guo Li
Filed: 18 Nov 20