15 patents
Utility
Crystalline and Amorphous Forms of a Delta-opioid Modulator
7 Dec 23
The present disclosure provides novel crystalline forms of a compound that acts as a δ-opioid effector, processes for preparing and precipitating amorphous and crystalline forms of the compound, and uses thereof.
Victoria A. Pollard, Laura E.N. Allan, Hayley A. Reece, Patrick J. Koestler
Filed: 27 Oct 21
Utility
5-MEMBERED Aza-heterocyclic Containing Delta-opioid Receptor Modulating Compounds, Methods of Using and Making the Same
28 Sep 23
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C.K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero
Filed: 10 May 23
Utility
Compounds for Modulating S1P1 Activity and Methods of Using the Same
27 Jul 23
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.
Philip Michael Pitis, Robert Eugene Boyd, Tamara Ann Miskowski Daubert, Michael John Hawkins, Guodong Liu, Aimee Crombie Speerschneider
Filed: 5 Apr 23
Utility
6-MEMBERED Aza-heterocyclic Containing Delta-opioid Receptor Modulating Compounds, Methods of Using and Making the Same
29 Jun 23
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C.K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero, Gregory J. Pacofsky
Filed: 3 Aug 22
Utility
Methods of Treating Epilepsy Using the Same
13 Apr 23
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same for the treatment of seizures, epilepsy related conditions, epilepsy-related syndrome, and the like as described herein.
Mark A. DEMITRACK, Michael S. KRAMER
Filed: 3 Sep 20
Utility
7-MEMBERED Aza-heterocyclic Containing Delta-opioid Receptor Modulating Compounds, Methods of Using and Making the Same
3 Nov 22
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
Aimee CROMBIE SPEERSCHNEIDER, Dennis SHINJI YAMASHITA, Philip Michael PITIS, Michael John HAWKINS, Guodong Liu, Tamara Ann MISKOWSKI DAUBERT, Catherine C.K. YUAN, Robert BORBO KARGBO, Robert Jason HERR, Donna ROMERO
Filed: 22 Nov 21
Utility
Opioid Receptor Ligands And Methods Of Using And Making Same
9 Jun 22
This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C.K. Yuan
Filed: 2 Jul 21
Utility
Beta-Arrestin Effectors and Compositions and Methods of Use Thereof
21 Oct 21
This application describes a family of compounds acting as β-arrestin effectors that can be used, for example, for treating acute respiratory distress syndrome, for preventing and treating thrombosis, platelet adhesion, and platelet aggregation, and/or for reducing a D-Dimer response, in a subject with ARDS or a viral infection, such as a coronavirus infection.
Mark A. Demitrack
Filed: 20 Apr 21
Utility
Compounds for Modulating S1P1 Activity and Methods of Using the Same
24 Jun 21
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.
Philip Michael PITIS, Robert Eugene BOYD, Tamara Ann Miskowski DAUBERT, Michael John HAWKINS, Guodong LIU, Aimee Crombie SPEERSCHNEIDER
Filed: 12 Jun 18
Utility
Compounds and Methods of Preparing Compounds S1P1 Modulators
20 May 21
The present embodiments are directed, in part, to processes and compositions that can, for example, be used in the preparation compounds of Formula (I), or a pharmaceutically acceptable salts thereof.
Brian H. Heasley, Jennifer Wilent, Patrick J. Koestler
Filed: 17 Nov 20
Utility
5-MEMBERED Aza-heterocyclic Containing Delta-opioid Receptor Modulating Compounds, Methods of Using and Making the Same
4 Mar 21
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
Aimee CROMBIE SPEERSCHNEIDER, Dennis SHINJI YAMASHITA, Philip Michael PITIS, Michael John HAWKINS, Guodong Liu, Tamara Ann MISKOWSKI DAUBERT, Catherine C.K. YUAN, Robert BORBO KARGBO, Robert Jason HERR, Donna ROMERO
Filed: 15 Feb 18
Utility
7-MEMBERED Aza-heterocyclic Containing Delta-opioid Receptor Modulating Compounds, Methods of Using and Making the Same
4 Mar 21
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
Aimee CROMBIE SPEERSCHNEIDER, Dennis SHINJI YAMASHITA, Philip Michael PITIS, Michael John HAWKINS, Guodong Liu, Tamara Ann MISKOWSKI DAUBERT, Catherine C.K. YUAN, Robert BORBO KARGBO, Robert Jason HERR, Donna ROMERO
Filed: 15 Feb 18
Utility
Methods of Treating Hyperalgesia
28 Jan 21
This application describes compounds and methods that can be used to treat, reverse, or avoid hyperalgesia.
Conrad Cowan, Michael Koblish, Michael W. Lark
Filed: 26 Feb 20
Utility
Corrected6-MEMBERED Aza-heterocyclic Containing Delta-opioid Receptor Modulating Compounds, Methods of Using and Making the Same
22 Jul 20
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C.K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero, Gregory J. Pacofsky
Filed: 26 Feb 19
Utility
Opioid Receptor Ligands And Methods Of Using And Making Same
13 Nov 19
This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C. K. Yuan
Filed: 24 Jul 19
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