33 patents
Utility
Pyruvate kinase modulators and use thereof
16 Jan 24
Giovanni Cianchetta, Charles Kung, Tao Liu, Anil Kumar Padyana, Zhihua Sui, Zhenwei Cai, Dawei Cui, Jingjing Ji
Filed: 27 Jan 22
Utility
Therapeutic compounds and compositions
9 Jan 24
Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein.
Francesco G. Salituro, Jeffrey O. Saunders, Shunqi Yan
Filed: 8 Mar 21
Utility
Pyruvate kinase activators for use in therapy
24 Oct 23
Described herein are methods for using compounds that activate pyruvate kinase.
Shin-San Michael Su, Lenny Dang
Filed: 2 Apr 21
Utility
Pyruvate kinase activators for use in treating blood disorders
28 Feb 23
Giovanni Cianchetta, Tao Liu, Anil Kumar Padyana, Zhihua Sui, Zhenwei Cai, Dawei Cui, Jingjing Ji
Filed: 15 Aug 18
Utility
Heterobicyclic inhibitors of MAT2A and methods of use for treating cancer
13 Dec 22
Zenon D. Konteatis, Mingzong Li, Peng Liu, Matthew Medeiros, Samuel K. Reznik, Zhihua Sui, Jeremy M. Travins, Janeta Popovici-Muller, Shubao Zhou, Guangning Ma
Filed: 28 Mar 19
Utility
Therapeutically active compounds and their methods of use
22 Nov 22
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
Giovanni Cianchetta, Byron DeLaBarre, Janeta Popovici-Muller, Francesco G. Salituro, Jeffrey O. Saunders, Jeremy Travins, Shunqi Yan, Tao Guo, Li Zhang
Filed: 18 Jun 20
Utility
Pyruvate kinase modulators and use thereof
11 Oct 22
Giovanni Cianchetta, Charles Kung, Tao Liu, Anil Kumar Padyana, Zhihua Sui, Zhenwei Cai, Dawei Cui, Jingjing Ji
Filed: 15 Aug 18
Utility
Methods of treating brain tumors using combination therapy
4 Oct 22
Provided are methods of treating a brain tumor in a patient in need thereof comprising administering to the patient a compound described herein and radiation therapy and/or one or more additional therapeutic agents.
Joshua Murtie, Nelamangala Nagaraja, Brandon Nicolay, David Schenkein, Katharine Yen
Filed: 12 Jun 18
Utility
Tablet compositions
19 Jul 22
Provided herein is a tablet comprising 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol or a pharmaceutically acceptable salt thereof.
Sreenivas S. Bhat, Scott Burnside, Darshan Parikh, Chong-Hui Gu, Syed Altaf
Filed: 6 Sep 17
Utility
Pyruvate kinase activators for use in treating blood disorders
21 Jun 22
Giovanni Cianchetta, Tao Liu, Anil Kumar Padyana, Zhihua Sui, Zhenwei Cai, Dawei Cui, Jingjing Ji
Filed: 15 Aug 18
Utility
Inhibitors of cellular metabolic processes
10 May 22
Zenon D. Konteatis, Zhihua Sui, Jeremy M. Travins, Zhixiong Ye
Filed: 24 Aug 20
Utility
Crystalline forms of N-(4-(4-(cyclopropymethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
22 Feb 22
Jacob P. Sizemore, Liting Guo, Mahmoud Mirmehrabi, Yeqing Su
Filed: 21 Nov 18
Utility
Methods of using pyruvate kinase activators
1 Feb 22
Described herein are methods for using compounds that activate pyruvate kinase.
Samuel V. Agresta, Yue Chen, Marvin B. Cohen, Lenny Dang, Charles Kung, Elizabeth A. Merica, Bruce A. Silver, Hua Yang
Filed: 10 Jun 16
Utility
Pyruvate kinase activators for use in treating blood disorders
22 Jun 21
Giovanni Cianchetta, Tao Liu, Anil Kumar Padyana, Zhihua Sui, Zhenwei Cai, Dawei Cui, Jingjing Ji
Filed: 19 Nov 20
Utility
Therapeutically active compounds and their methods of use
1 Jun 21
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
Rene M. Lemieux, Janeta Popovici-Muller, Jeremy Travins, Zhenwei Cai, Dawei Cui, Ding Zhou
Filed: 11 May 20
Utility
Therapeutic compounds and compositions
27 Apr 21
Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein.
Francesco G. Salituro, Jeffrey O. Saunders, Shunqi Yan
Filed: 9 Jan 19
Utility
Therapeutically active compounds and their methods of use
16 Mar 21
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
Zenon D. Konteatis, Janeta Popovici-Muller, Jeremy Travins, Robert Zahler, Zhenwei Cai, Ding Zhou
Filed: 23 Oct 18
Utility
Combination therapy for treating malignancies
2 Feb 21
Provided are methods and compositions for treating AML in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and an AML induction and consolidation therapy.
Samuel V. Agresta
Filed: 14 Oct 16
Utility
Pharmaceutical compositions of therapeutically active compounds
12 Oct 20
Provided are compounds and pharmaceutical compositions useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound or pharmaceutical composition described herein.
Chong-Hui Gu
Filed: 1 Jul 19
Utility
Inhibitors of cellular metabolic processes
12 Oct 20
Zenon D. Konteatis, Zhihua Sui, Jeremy M. Travins, Zhixiong Ye
Filed: 12 Dec 18