17 patents
Utility
Complement Factor D Antagonist Antibodies and Conjugates Thereof
30 Nov 23
The present invention provides antagonizing antibodies that bind to complement factor D (CFD), conjugates thereof, and methods of using same.
Daniel Victor Perlroth, Wah Yuen To, Hong Liang, Rachel Marie DeVay Jacobson, Fernando CorrĂȘa
Filed: 6 Feb 23
Utility
Multifunctional zwitterionic polymer conjugates
21 Nov 23
The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.
Stephen A. Charles, D. Victor Perlroth, Lane A. Clizbe, Didier G. Benoit, Wayne To
Filed: 14 Apr 16
Utility
CorrectedMultifunctional Zwitterionic Polymer Conjugates
7 Sep 23
The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.
Stephen A. Charles, D. Victor Perlroth, Lane A. Clizbe, Didier G. Benoit, Wayne To
Filed: 14 Apr 16
Utility
Methods of Purifying a Product
10 Aug 23
Provided herein are embodiments relating to affinity chromatography purification and separation of contaminant species, including HCPs (Host Cell Proteins), from desired molecular and chemical species.
Andreas Sebastian Zurbriggen, Carole In-Albon
Filed: 9 Feb 23
Utility
Factor VIII zwitterionic polymer conjugates
28 Feb 23
The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
Stephen A. Charles, Daniel Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
Filed: 4 Feb 20
Utility
Complement factor D antagonist antibodies and conjugates thereof
21 Feb 23
The present invention provides antagonizing antibodies that bind to complement factor D (CFD), conjugates thereof, and methods of using same.
Daniel Victor Perlroth, Wah Yuen To, Hong Liang, Rachel Marie DeVay Jacobson, Fernando CorrĂȘa
Filed: 12 Apr 18
Utility
Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation
31 Mar 22
The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
Stephen A. Charles
Filed: 16 Dec 21
Utility
High Molecular Weight Zwitterion-containing Polymers
30 Dec 21
The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers.
Stephen A. CHARLES, Daniel Victor PERLROTH, Didier G. BENOIT, Lane A. CLIZBE, Wayne TO, Linda J. ZADIK, Jeanne M. PRATT
Filed: 23 Aug 21
Utility
Dual PDGF/VEGF antagonists
26 Oct 21
The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist.
Daniel Victor Perlroth, Stephen A. Charles, James Aggen, Didier Benoit, Wayne To, Lidia Mosyak, Laura Lin, Justin Cohen, Tetsuya Ishino, William Somers
Filed: 21 Nov 17
Utility
Antibodies and Conjugates Thereof
21 Oct 21
Provided herein are anti-VEGF-A antibodies and antibody conjugates thereof.
Daniel Victor Perlroth, Wah Yuen To, Hong Liang
Filed: 8 Apr 21
Utility
Butyrylcholinesterase zwitterionic polymer conjugates
27 Jul 21
The present invention provides recombinant butyrylcholinesterase fusion proteins, including Fc fusion proteins and multi-armed high MW polymers containing hydrophilic groups conjugated to the fusion proteins, and methods of preparing such polymers.
Daniel Victor Perlroth, Stephen A. Charles, Wayne To, Xiaojian Huang, Martin Linsell, Didier Benoit
Filed: 3 May 19
Utility
Antibodies and conjugates thereof
20 Jul 21
Provided herein are anti-VEGF-A antibodies and antibody conjugates thereof.
Daniel Victor Perlroth, Wah Yuen To, Hong Liang
Filed: 29 Dec 16
Utility
Dual Pdgf/vegf Antagonists
19 Aug 20
The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist.
D. Victor Perlroth, Stephen A. Charles, James Aggen, Didier Benoit, Wayne To, Lidia Mosyak, Laura Lin, Justin Cohen, Tetsuya Ishino, William Somers
Filed: 18 Feb 20
Utility
Factor VIII Zwitterionic Polymer Conjugates
19 Aug 20
The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
Stephen A. Charles, D. Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
Filed: 3 Feb 20
Utility
Factor VIII zwitterionic polymer conjugates
6 Jul 20
The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
Stephen A. Charles, D. Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
Filed: 7 Sep 14
Utility
High Molecular Weight Zwitterion-containing Polymers
3 Jun 20
The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers.
Stephen A. Charles, D. Victor Perlroth, Didier G. Benoit, Lane A. Clizbe, Wayne To, Linda J. Zadik, Jeanne M. Pratt
Filed: 30 Jan 20
Utility
Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation
1 Jan 20
The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
Stephen A. Charles
Filed: 27 May 19
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