15 patents
Utility
Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds
17 Oct 23
Described herein are methods of disrupting (e.g., reducing the viscosity of, or dissolving) a preformed biofilm in a subject, the method comprising: administering to the subject an effective amount of a composition comprising a soluble chitosan or derivatized chitosan wherein the soluble chitosan or derivatized chitosan when administered contacts the preformed biofilm, thereby disrupting (e.g., reducing the viscosity of, or dissolving) the preformed biofilm.
Shenda M. Baker, William P. Wiesmann, Stacy Marie Townsend
Filed: 16 Sep 19
Utility
Methods and compositions for treating wounds utilizing chitosan compounds
8 Aug 23
Described herein are methods of treating wounds, the method comprising administering to a subject an effective amount of a composition comprising a soluble or derivatized chitosan wherein the soluble or derivatized chitosan when administered contacts the wound, thereby treating the wound.
Shenda M. Baker, William P. Wiesmann, Ruth Baxter
Filed: 16 Mar 18
Utility
Compositions and Methods of Use Thereof
29 Jun 23
Described herein are methods of treating a Nontuberculosis Mycobacteria (NTM) infection in a subject in need thereof, the methods comprising administering an effective amount of a polyglucosamine derivative or a composition comprising a polyglucosamine derivative.
Shenda M. Baker, William P. Wiesmann
Filed: 30 Apr 21
Utility
Compositions and Methods of Their Use
19 Jan 23
Provided herein are methods of treating (e.g., inhibiting, modulating, reversing, or reducing the severity of at least one symptom of) a dysbiosis in a subject, the method comprising administering an effective amount of a composition described herein (e.g., a composition comprising polyglucosamine-arginine (PAAG)).
Shenda M. Baker, William P. Wiesmann, Stacy Marie Townsend
Filed: 11 Feb 22
Utility
Compositions and methods of use for wound healing
6 Sep 22
Described herein are a solution, composition, and kit of poly (acetyl, arginyl) glucosamine (PAAG), methods of making the solution, and method of treating wounds with the solution, the method comprising administering to a subject an effective amount of a solution comprising PAAG, wherein the PAAG when administered topically contacts the wound, thereby treating the wound.
Shenda M. Baker, William P. Wiesmann, Stacy M. Townsend
Filed: 14 Mar 14
Utility
Derivatized Chitosan Polymers and Methods of Treating Vascular Disorders
26 May 22
Described herein are methods for treating inflammation, swelling and secondary damage of the vascular and lymphatic system in a subject, for example of the brain, spinal cord, and lungs; from organ reperfusion, e.g., resulting from endothelial leakage, glycocalyx dysfunction or loss of structural integrity of the glycocalyx.
Shenda Baker, William P. Wiesmann
Filed: 29 Jun 21
Utility
Methods for Treatment or Prevention of Damage Resulting from Radiation, Trauma or Shock
16 Dec 21
Described herein are methods of treating a subject that has been or will be exposed to radiation, trauma or shock, the method comprising identifying a subject that has been or will be exposed to radiation, and treating the subject with a compound that treats, reduces the severity or delays the onset of sepsis or reduces the likelihood of mortality in a subject upon administration of a therapeutically effective amount the compound to the subject.
Shenda M. Baker, William P. Wiesmann
Filed: 15 Jan 21
Utility
Derivatized chitosan polymers and methods of treating vascular disorders
3 Aug 21
Described herein are methods for treating inflammation, swelling and secondary damage of the vascular and lymphatic system in a subject, for example of the brain, spinal cord, and lungs; from organ reperfusion, e.g., resulting from endothelial leakage, glycocalyx dysfunction or loss of structural integrity of the glycocalyx.
Shenda Baker, William P. Wiesmann
Filed: 12 Aug 16
Utility
Chitosan-derivative Compounds and Methods of Controlling Microbial Populations
23 Sep 20
The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments.
Shenda M. Baker, William P. Wiesmann
Filed: 22 Oct 19
Utility
Oral formulation of polyglucosamine derivatives in combination with a non-fermentable sugar
7 Sep 20
Described herein are methods and compositions that contain a soluble polyglucosamine or polyglucosamine derivative for use in oral health.
Stacy M. Townsend, Shenda M. Baker, William P. Wiesmann
Filed: 8 Apr 18
Utility
Methods for treatment or prevention of damage resulting from radiation, trauma or shock
20 Jul 20
Described herein are methods of treating a subject that has been or will be exposed to radiation, trauma or shock, the method comprising identifying a subject that has been or will be exposed to radiation, and treating the subject with a compound that treats, reduces the severity or delays the onset of sepsis or reduces the likelihood of mortality in a subject upon administration of a therapeutically effective amount the compound to the subject.
Shenda M. Baker, William P. Wiesmann
Filed: 12 Jun 18
Utility
Derivatized Polyglucosamines for Delivery of Small Molecules, Peptides, and Proteins
26 Feb 20
Described herein are compositions comprising a derivatized polyglucosamine and a small molecule, peptide, or protein and related methods of use, e.g., to deliver a small molecule, peptide, or protein to cells (e.g., cancer cells) or tissues (e.g., mucosal membrane and epithelial membrane), e.g., to treat a disease or condition at a subject.
Shenda M. Baker, Ruth Baxter, William P. Wiesmann
Filed: 30 Apr 19
Utility
Methods and Compositions for Disrupting Biofilm Utilizing Chitosan-derivative Compounds
8 Jan 20
Described herein are methods of disrupting (e.g., reducing the viscosity of, or dissolving) a preformed biofilm in a subject, the method comprising: administering to the subject an effective amount of a composition comprising a soluble chitosan or derivatized chitosan wherein the soluble chitosan or derivatized chitosan when administered contacts the preformed biofilm, thereby disrupting (e.g., reducing the viscosity of, or dissolving) the preformed biofilm.
Shenda M. Baker, William P. Wiesmann, Stacy Marie Townsend
Filed: 15 Sep 19
Utility
Compositions and Methods of Use Thereof
8 Jan 20
Described herein are methods for treating or preventing a disease or disorder of the pulmonary system (e.g., cystic fibrosis), respiratory or digestive system in a subject, the methods comprising administering compounds or compositions comprising water soluble polyglucosamine and derivatized polyglucosamine.
Shenda M. Baker, William P. Wiesmann, Stacy Marie Townsend
Filed: 16 Sep 19
Utility
Chitosan-derivative compounds and methods of controlling microbial populations
2 Dec 19
The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments.
Shenda M. Baker, William P. Wiesmann
Filed: 11 Jul 17
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