12 patents
Utility
Composition and methods based on neutralizing antibodies delivered intranasally for enhanced therapeutic efficacy
28 Nov 23
The present invention provides methods for treatment or prophylaxis of viruses, particularly influenza virus, by administration of agents, particularly neutralizing antibodies or active fragments thereof, directly to the respiratory tract, including by intranasal or inhalation administration.
Michael Wittekind, Adam Vigil
Filed: 14 Mar 14
Utility
Gram-negative lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof in human serum
3 Oct 23
The present disclosure is directed to lysin-AMP polypeptide constructs, isolated lysin polypeptides, and pharmaceutical compositions comprising the isolated polypeptides and/or lysin-AMP polypeptide constructs.
Raymond Schuch
Filed: 29 Mar 19
Utility
Biofilm prevention, disruption and treatment with bacteriophage lysin
13 Dec 22
The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2.
Raymond Schuch, Robert C. Nowinski, Michael Wittekind, Babar Khan, Jimmy Rotolo
Filed: 22 Apr 19
Utility
Lysin polypeptides active against Gram-negative bacteria
16 Aug 22
The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa.
Raymond Schuch, Simon Hoffenberg, Michael Wittekind
Filed: 9 Jul 20
Utility
Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby
14 Jun 22
The present disclosure relates to methods for restoring or augmenting bactericidal activity of an antibiotic in an organ or tissue in which pulmonary surfactant is present.
Michael Wittekind, Raymond Schuch
Filed: 16 Sep 16
Utility
Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
15 Feb 22
Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus.
Angeles Estelles, Lawrence M. Kauvar, Adam Vigil, Michael Wittekind
Filed: 5 Nov 19
Utility
Lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof
27 Apr 21
The present disclosure is directed to a lysin-AMP polypeptide construct comprising: (a) a first component comprising the polypeptide sequence of: (i) SEQ ID NO: 118 (GN202); or (ii) a polypeptide having lysin activity and having at least 80% sequence identity with the polypeptide sequence of SEQ ID NO: 118 (GN202); or (iii) an active fragment of SEQ ID NO: 118 (GN202); and (b) a second component comprising the polypeptide sequence of at least one antimicrobial peptide (AMP), wherein the at least one AMP comprises SEQ ID NO: 114 (FIRL).
Raymond Schuch
Filed: 30 Jan 20
Utility
Broth microdilution method for evaluating and determining minimal inhibitory concentration of antibacterial polypeptides
30 Nov 20
The present invention provides components, assays and methods for evaluating antibacterial effectiveness and determining minimal inhibitory concentration (MIC) of polypeptides, including lysin polypeptides, that kill bacteria.
Raymond Schuch
Filed: 11 May 17
Utility
Bacteriophage lysin and antibiotic combinations against gram positive bacteria
26 Oct 20
The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).
Raymond Schuch, Robert C. Nowinski, Michael Wittekind, Han Lee, Brent Schneider
Filed: 8 May 13
Utility
Lysin polypeptides active against Gram-negative bacteria
17 Aug 20
The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa.
Raymond Schuch, Simon Hoffenberg, Michael Wittekind
Filed: 15 Sep 16
Utility
Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
4 May 20
Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus.
Angeles Estelles, Lawrence M. Kauvar, Adam Vigil, Michael Wittekind
Filed: 3 Feb 15
Utility
Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria
16 Mar 20
The present invention relates to methods and compositions for use in modulating, including inhibiting the growth and/or reducing the virulence of, gram-positive bacteria.
Robert C. Nowinski, Vincent A. Fischetti, Assaf Raz
Filed: 10 Aug 17
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