29 patents
Page 2 of 2
Utility
Synthetic Strands For Nucleic Acid Sequencing And Related Methods And Systems
6 May 21
Provided are synthetic strands for nucleic acid sequencing.
Harlan S. Robins
Filed: 5 Nov 20
Utility
Compositions and methods for measuring and calibrating amplification bias in multiplexed PCR reactions
19 Jan 21
Compositions and methods are described for standardizing the DNA amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of DNA templates that contains rearranged lymphoid cell DNA encoding T cell receptors (TCR) or immunoglobulins (IG).
Harlan Saul Robins, Christopher Scott Carlson, Robert J. Livingston, Ryan O. Emerson, Anna M. Sherwood
Filed: 8 Jan 19
Utility
Monitoring health and disease status using clonotype profiles
14 Dec 20
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias.
Malek Faham, Thomas Willis
Filed: 4 Sep 18
Utility
Methods Using Randomer-Containing Synthetic Molecules
14 Oct 20
Methods are provided for correction of amplification bias and quantitation of adaptive immune cells in a sample using synthetic templates that include random oligonucleotide sequences.
Anna M. SHERWOOD, Ryan O. EMERSON, Harlan S. ROBINS, Mark J. RIEDER, Joe PARSONS
Filed: 30 Apr 20
Utility
Monitoring health and disease status using clonotype profiles
31 Aug 20
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias.
Malek Faham, Thomas Willis
Filed: 29 Nov 17
Utility
Method for genotyping clonotype profiles using sequence tags
6 Jan 20
The invention is directed to sequence-based profiling of populations of nucleic acids by multiplex amplification and attachment of one or more sequence tags to target nucleic acids and/or copies thereof followed by high-throughput sequencing of the amplification product.
Thomas Asbury, Kieran Hervold, Chitra Kotwaliwale, Malek Faham, Martin Moorhead, Li Weng, Tobias Wittkop, Jianbiao Zheng
Filed: 1 Aug 18
Utility
Monitoring health and disease status using clonotype profiles
30 Dec 19
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias.
Malek Faham, Thomas Willis
Filed: 8 Jun 17
Utility
Determining antigen-specific T-cells
7 Oct 19
The invention is directed to methods for determining antigen-specific T cells.
Mark Klinger, Malek Faham
Filed: 29 Nov 17
Utility
Identification of antigen-specific B cell receptors
30 Sep 19
Compositions and methods are disclosed for identifying B-cell receptor sequences that bind to corresponding antigens.
Mark Klinger
Filed: 19 Sep 17