25 patents
Utility
Treatment of Recurrent Gioblastoma with Perillyl Alcohol
21 Dec 23
The present invention provides an intranasal glioblastoma therapy with purified perillyl alcohol.
Thomas C. CHEN
Filed: 12 Nov 21
Utility
Methods of Permeabilizing the Blood Brain Barrier
10 Aug 23
The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.
Thomas CHEN
Filed: 27 Mar 23
Utility
Methods of Permeabilizing the Blood Brain Barrier
27 Jul 23
The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.
Thomas CHEN
Filed: 27 Mar 23
Utility
Compositions and Methods for Delivering Polynucleotides
6 Jul 23
The disclosure relates to compositions, methods, and kits for using perillyl alcohol and/or an Argonaute protein (e.g., Ago-2) to deliver a polynucleotide to a cell.
Thomas C. CHEN
Filed: 8 Jun 21
Utility
Pharmaceutical Compositions Comprising Poh Derivatives and Methods of Use
11 May 23
The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester.
Thomas CHEN, Daniel LEVIN, Satish PUPPALI
Filed: 6 Jan 23
Utility
Pharmaceutical Compositions Comprising Perillyl Alcohol Derivatives
9 Feb 23
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail.
Thomas CHEN, Daniel LEVIN, Satish Puppali
Filed: 13 Sep 22
Utility
Pharmaceutical Compositions Comprising Poh Derivatives
1 Dec 22
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative.
Thomas CHEN, Axel SCHÖNTHAL
Filed: 23 Sep 20
Utility
Pharmaceutical Compositions Comprising Monoterpenes
17 Nov 22
The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w).
Thomas CHEN, Daniel LEVIN, Satish PUPPALI
Filed: 20 May 22
Utility
Pharmaceutical Compositions Comprising Poh Derivatives
5 May 22
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative.
Thomas CHEN, Daniel LEVIN, Satish PUPPALI
Filed: 12 Jan 22
Utility
Methods of Treating Cancer Using Compositions Comprising Perillyl Alcohol Derivative
31 Mar 22
A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ-POH.
Thomas CHEN
Filed: 30 Jul 21
Utility
Methods of Treating Neurofibromatosis with Perillyl Alcohol
24 Feb 22
The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol.
Thomas CHEN
Filed: 18 Oct 21
Utility
Pharmaceutical Compositions Comprising Poh Derivatives
16 Sep 21
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative.
Thomas CHEN, Daniel LEVIN, Satish PUPPALI
Filed: 6 May 21
Utility
Pharmaceutical Compositions Comprising Poh Derivatives
2 Sep 21
The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram.
Thomas CHEN, Daniel LEVIN, Satish PUPPALI
Filed: 3 May 21
Utility
Pharmaceutical Compositions Comprising Poh Derivatives
12 Aug 21
The present invention provides a method for treating inflammation in a mammal.
Thomas CHEN, Daniel LEVIN, Satish PUPPALI
Filed: 17 Jun 19
Utility
Methods of Permeabilizing the Blood Brain Barrier
29 Jul 21
The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.
Thomas CHEN
Filed: 7 Feb 19
Utility
Pharmaceutical Compositions Comprising Monoterpenes
6 May 21
The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w).
Thomas CHEN, Daniel LEVIN, Satish PUPPALI
Filed: 16 Dec 20
Utility
Pharmaceutical Compositions Comprising Perillyl Alcohol Derivatives
2 Sep 20
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail.
Thomas CHEN, Daniel LEVIN, Satish Puppali
Filed: 17 May 20
Utility
Pharmaceutical Compositions Comprising Poh Derivatives and Methods of Use
29 Jul 20
The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester.
Thomas CHEN, Daniel LEVIN, Satish PUPALLI
Filed: 17 Apr 18
Utility
Methods of Treating Cancer Using Compositions Comprising Perillyl Alcohol Derivative
22 Jul 20
A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ-POH.
Thomas CHEN
Filed: 19 Dec 19
Utility
Methods and Devices for Using Isoperillyl Alcohol
3 Jun 20
The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol.
Thomas Chen, Daniel Levin, Satish Pupalli, Daniel Anthony Dickman
Filed: 5 Nov 19