47 patents
Utility
Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
9 Jan 24
The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety.
Albert J. Sinusas, Joseph G. Akar, Richard R. Cesati, Heike S. Radeke, Stephen B. Haber
Filed: 22 May 20
Utility
Methods for making ultrasound contrast agents
2 Jan 24
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 19 May 21
Utility
Methods for Making Ultrasound Contrast Agents
19 Oct 23
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 19 May 23
Utility
Methods for Making Ultrasound Contrast Agents
21 Sep 23
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 22 May 23
Utility
Compositions, methods, and systems for the synthesis and use of imaging agents
5 Sep 23
The present invention provides compounds with imaging moieties for imaging a subject.
Richard R. Cesati, Heike S. Radeke, Suresh K. Pandey, Ajay Purohit, Simon P. Robinson
Filed: 25 Oct 19
Utility
Methods and Devices for Preparation of Ultrasound Contrast Agents
31 Aug 23
Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.
Joel Lazewatsky
Filed: 3 Aug 21
Utility
System and Method for Quantitative Mapping of Mitochondrial Complex 1
22 Dec 22
A system and method is provided for processing a positron emission tomography (PET) image of a subject having received a dose of a radiotracer that serves as chemical analog of an MC-I inhibitor.
Georges El Fakhri, Nathaniel Alpert
Filed: 4 Feb 22
Utility
Methods for making ultrasound contrast agents
20 Dec 22
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 7 Mar 22
Utility
Lipid-encapsulated Gas Microsphere Compositions and Related Methods
15 Dec 22
The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
Simon P. Robinson, Robert W. Siegler, David C. Onthank, Nhung Tuyet Nguyen
Filed: 24 Jun 22
Utility
Compositions, Methods, and Systems for the Synthesis and Use of Imaging Agents
27 Oct 22
The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof.
Heike S. Radeke, Richard R. Cesati, Ajay Purohit, Thomas D. Harris, Simon P. Robinson, Ming Yu, David S. Casebier, Carol Hui Hu, Matthias Broekema, David C. Onthank
Filed: 20 Apr 22
Utility
Ligands for Imaging Cardiac Innervation
15 Sep 22
Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed.
Ajay Purohit, Thomas D. Harris, Heike S. Radeke, Simon P. Robinson, Ming Yu, David S. Casebier, Michael T. Azure
Filed: 28 Jan 22
Utility
Lipid-encapsulated gas microsphere compositions and related methods
26 Jul 22
The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
Simon P. Robinson, Robert W. Siegler, David C. Onthank, Nhung Tuyet Nguyen
Filed: 3 Feb 20
Utility
Methods for Making Ultrasound Contrast Agents
23 Jun 22
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 7 Mar 22
Utility
CorrectedMethods for Making Ultrasound Contrast Agents
23 Jun 22
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 19 May 21
Utility
Methods for Making Ultrasound Contrast Agents
16 Jun 22
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 7 Mar 22
Utility
Pierceable Plug for Needle
16 Jun 22
A pierceable plug for closing off a piercing end of a needle is described herein.
Joseph Haepers, Jack N. Wentz, JR., Virginia Ann Hankard, Khursida Shahidullah, Tricia D. Butland, Patricia A. Corosa, David P. Rice, Samantha Moran
Filed: 1 May 20
Utility
Methods for making ultrasound contrast agents
31 May 22
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 6 Feb 18
Utility
Control System for Radiopharmaceuticals
26 May 22
Techniques for monitoring a pharmaceutical manufacturing process and making determinations regarding the release of radiopharmaceuticals to health care providers.
Derek F. Rhodes, Robert W. Siegler
Filed: 7 Oct 21
Utility
Methods for making ultrasound contrast agents
8 Mar 22
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 5 Jul 17
Utility
Methods for making ultrasound contrast agents
8 Mar 22
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Filed: 19 May 21