110 patents
Page 2 of 6
Utility
Prodrugs of Fumarates and Their Use in Treating Various Diseases
10 Nov 22
Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
Filed: 9 Dec 21
Utility
Bicyclic Inhibitors of Histone Deacetylase
27 Oct 22
Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g,.
Nathan Oliver Fuller, John A. Lowe, III
Filed: 22 Dec 21
Utility
Upar Antibodies and Fusion Proteins with the Same
27 Oct 22
The disclosure provides urokinase plasminogen activator receptor (uPAR) binding polypeptides (e.g., uPAR antigen binding proteins), and fusion proteins comprising said uPAR binding polypeptides and a cytokine or variant thereof.
Jijun Dong, Pinar Gurel, Joshua Heiber
Filed: 23 Mar 22
Utility
Bicyclic Inhibitors of Histone Deacetylase
27 Oct 22
Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
Nathan Oliver Fuller, John A. Lowe, III
Filed: 22 Dec 21
Utility
Methods for Treating Antipsychotic-induced Weight Gain
8 Sep 22
The present invention relates to the discovery of a novel opioid modulator effective in reducing pharmacologically induced weight gain associated with atypical antipsychotic use.
Daniel R. Deaver, Mark Todtenkopf
Filed: 20 Oct 21
Utility
Synthesis of Bicyclic Inhibitors of Histone Deacetylase
25 Aug 22
Nathan Oliver Fuller, Michael Charles Hewitt, Sylvie M. Asselin, Wayne Douglas Luke
Filed: 23 Jul 20
Utility
Monomethylfumarate Prodrug Compositions
18 Aug 22
David S. Manser, Hardik Kirtikumar Shah, Kristopher K. Perkin, Ivan Browning
Filed: 29 Sep 21
Utility
Aripiprazole formulations having increased injection speeds
9 Aug 22
The present invention relates to pharmaceutical compositions comprising a compound of Formula (I) that are useful for the intramuscular delivery of antipsychotic drugs using rapid injection rates.
Magali B. Hickey, Jennifer Vandiver
Filed: 1 Jun 20
Utility
Compositions and Methods for Subcutaneous Administration of Cancer Immunotherapy
4 Aug 22
The invention provides compositions, methods and treatment regimens for treating cancer comprising periodic subcutaneous administration of the fusion protein of SEQ ID NO:1 to a cancer patient resulting in enhanced activation of CD8+ T-cells with minimal effects on regulatory T cell (Treg) expansion and providing enhanced anti-tumor efficacy while also mitigating T cell inactivation/exhaustion.
Heather C. Losey, Jared Lopes, Lei Sun, Raymond J. Winquist
Filed: 4 Jan 22
Utility
Immunomodulatory IL-2 Agents In Combination with Immune Checkpoint Inhibitors
21 Jul 22
The invention provides compositions and methods of treating cancer in a patient with a combination therapy comprising a fusion protein of SEQ ID NO: 1 in combination with an immune checkpoint inhibitor.
Heather C. Losey, Jared Lopes, Raymond J. Winquist
Filed: 4 Jan 22
Utility
Substituted Macrocyclic Compounds and Related Methods of Treatment
23 Jun 22
The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof.
Lewis D. Pennington, Younggi Choi, Hoan Huynh, Brian M. Aquila, Ingo Andreas Mugge, Yuan Hu, James R. Woods, Brian Kenneth Raymer, Jörg Martin Bentzien, Jonathan Ward Lehmann, Michael R. Hale, Srinivasa Karra, Roman A. Valiulin, Daljit Matharu
Filed: 20 Dec 21
Utility
Substituted Piperidino Compounds and Related Methods of Treatment
23 Jun 22
The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof.
Lewis D. Pennington, Younggi Choi, Hoan Huynh, Brian M. Aquila, Ingo Andreas Mugge, Yuan HU, James R. Woods, Brian Kenneth Raymer, Jörg Martin Bentzien, Jonathan Ward Lehmann, Srinivasa Karra, Roman A. Valiulin, Daljit Matharu
Filed: 20 Dec 21
Utility
Methods for treating antipsychotic-induced weight gain
7 Jun 22
The present invention relates to the discovery of a novel opioid modulator effective in reducing pharmacologically induced weight gain associated with atypical antipsychotic use.
Daniel R. Deaver, Mark Todtenkopf
Filed: 15 Oct 20
Utility
Sustained Release Aminopyridine Composition
12 May 22
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at least 12 hours, preferably 24 hours or more and the use of the composition to treat various neurological diseases.
Sean Cunningham, Seamus Mulligan, Michael Myers
Filed: 28 Jan 22
Utility
Prodrugs of Fumarates and Their Use In Treating Various Diseases
31 Mar 22
Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
Filed: 1 Jul 21
Utility
Bicyclic inhibitors of histone deacetylase
29 Mar 22
Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g,.
Nathan Oliver Fuller, John A. Lowe, III
Filed: 21 May 20
Utility
Aripiprazole Prodrug Composition
17 Mar 22
Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug.
Philip CRESSWELL, Magali HICKEY, Kristopher PERKIN, Greg SMITH, Elaine LIVERSIDGE, Brian STEINBERG, David MANSER, Tarek ZEIDAN
Filed: 12 Oct 21
Utility
Aripiprazole dosing strategy
15 Mar 22
The present invention relates to methods of treating schizophrenia using a combination of aripiprazole, aripiprazole lauroxil, and a nanoparticle dispersion of aripiprazole lauroxil.
Lisa L. von Moltke, Peter J. Weiden, Marjie L. Hard
Filed: 4 Mar 19
Utility
Pharmaceutical Compositions Having Improved Storage Stability
10 Mar 22
The present invention relates to a pharmaceutical composition that provides long-term stability of a hydrolytically labile antipsychotic agent
Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver, Michael J. Palmieri, JR., Zhengzheng Pan
Filed: 10 Aug 21
Utility
Reduction of flake-like aggregation in nanoparticulate active agent compositions
22 Feb 22
This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions.
Niels P. Ryde, Peter Snyder, Wei Liu, David M. Slifer
Filed: 4 May 18