4 patents
Utility
Methods to improve reduction or labeling of carbohydrates
3 Jan 23
The present invention provides methods, devices, and kits to improve procedures for reducing carbohydrates, such as glycans released from glycoconjugates, or for labeling carbohydrates by reductive amination.
Andres Guerrero Navarro
Filed: 22 Mar 18
Utility
Use of quaternary and tertiary ammonium cations to denature proteins
7 Sep 21
Ammonium cation detergents comprising a quaternary or tertiary ammonium cation can be used as detergents to denature proteins and are particularly useful in denaturing glycoproteins or glycopeptides prior to enzymatic deglycosylation.
Michael J. Kimzey, Francis T. Haxo, Vaishali Sharma
Filed: 17 Aug 17
Utility
Use of mild electrophiles to reduce artifacts in analyzing glycans released from glycoproteins or glycopeptides
15 Jun 21
The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or glycopeptides.
Michael J. Kimzey
Filed: 16 Aug 17
Utility
Compound for labeling amine-containing compounds, and its use
11 May 21
The invention relates to an activated form of procaine, and the use of the activated procaine, or salts or solvates thereof, to label amine-containing compounds, such as N-glycans, amine-containing amino acids, amine-containing peptides, amine-containing proteins, or other amine-containing compounds in a sample.
Michael J. Kimzey, Alexander Gyenes
Filed: 27 May 16
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