10 patents
Utility
System for isolating and analyzing cells in a single-cell format
23 Dec 19
A system and method for isolating and analyzing single cells, comprising: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
Kalyan Handique, Priyadarshini Gogoi, Saedeh Javdani Sepehri, Kyle Gleason
Filed: 29 Jul 18
Utility
System for imaging captured cells
16 Dec 19
A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor.
Kaylan Handique, Kyle Gleason, Christopher Siemer, Priyadarshini Gogoi, Saedeh Sepehri Javdani, Gene Parunak, Aaron Kehrer, Jon Meines
Filed: 12 Feb 17
Utility
Cell Capture System and Method of Use
4 Dec 19
A cell capture system including an array, an inlet manifold, and an outlet manifold.
Kalyan Handique
Filed: 7 Aug 19
Utility
System and Method for Retrieving and Analyzing Particles
20 Nov 19
A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
Kalyan Handique, Austin Payne, Vishal Sharma, Kyle Gleason, Priyadarshini Gogoi, Karthik Ganesan, Brian Boniface, Will Chow
Filed: 1 Aug 19
Utility
Cell capture system and method of use
18 Nov 19
A cell capture system including an array, an inlet manifold, and an outlet manifold.
Kalyan Handique
Filed: 7 Aug 19
Utility
System and Method for Isolating and Analyzing Cells
6 Nov 19
A system and method for isolating and analyzing single cells, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity configured to capture cells in one of a single-cell format and single-cluster format, and a fluid delivery module including a fluid reservoir superior to the array of wells through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: capturing a population of non-cell particles into the array of wells in single-particle format; releasing, from the non-cell particles, a set of probes into the array of wells; capturing a population of cells into the array of wells in single-cell format; releasing biomolecules from each captured cell into the array of wells; and generating a set of genetic complexes comprising the biomolecules associated with a single captured cell and a subset of probes within individual wells of the array of wells.
Kalyan Handique, Vishal Sharma
Filed: 9 Jul 19
Utility
System and method for retrieving and analyzing particles
4 Nov 19
A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
Kalyan Handique, Austin Payne, Vishal Sharma, Kyle Gleason, Priyadarshini Gogoi, Karthik Ganesan, Brian Boniface, Will Chow
Filed: 15 Nov 17
Utility
System and method for isolating and analyzing cells
21 Oct 19
A system and method for isolating and analyzing single cells, comprising: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
Kalyan Handique, Priyadarshini Gogoi, Saedeh Javdani Sepehri, Kyle Gleason
Filed: 29 Jul 18
Utility
Cell capture system and method of use
7 Oct 19
A cell capture system including an array, an inlet manifold, and an outlet manifold.
Kalyan Handique, Pridyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
Filed: 15 Jul 19
Utility
Cell Capture System and Method of Use
2 Oct 19
A cell capture system including an array, an inlet manifold, and an outlet manifold.
Kalyan Handique, Pridyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
Filed: 16 Jun 19
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