485 patents
Page 14 of 25
Utility
ANTI-B7-H3 Antibodies and Antibody Drug Conjugates
10 Jun 21
The invention relates to B7 homology 3 protein (B7-H3) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
Lorenzo Benatuil, Debra Chao, Kamel Izeradjene, Andrew S. Judd, Andrew C. Phillips, Andrew J. Souers, Archana Thakur, Milan Bruncko
Filed: 13 Mar 20
Utility
Methods of Treating Heavy Menstrual Bleeding
27 May 21
The present invention relates to the method of treating heavy menstrual bleeding in a subject with or without uterine fibroids and in need of treatment by administering an effective amount of 4-((R)-2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino)-butyric acid or a pharmaceutically acceptable salt thereof, in combination with estrogens and progestogens.
Kristof Chwalisz, Jane Castelli-Haley, Oscar Antunez Flores, Keith Gordon, Rita Jain, Juki Wing-Keung Ng, Janine D. North, Charlotte D. Owens, Hannah Palac, Paul M. Peloso, Michael C. Snabes, Ahmed M. Soliman, James W. Thomas
Filed: 23 Jul 18
Utility
Composition and Method for the Diagnosis and Treatment of Iron-related Disorders
27 May 21
Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.
Bernhard Mueller, Andreas Popp, Jennifer M. Perez
Filed: 28 Sep 20
Utility
Managing Healthcare Services
27 May 21
System and method for facilitating a medical order/prescription of a prescription product, including a memory device to store predefined forms for the prescription product corresponding to a plurality of providers.
Peter Carl Stueckemann, Pankaj Dubey, Richard Lanier, Prakash Venkataramanan, Vaibhav Jindal, Shannon Marie Sword
Filed: 5 Jan 21
Utility
1,2,3,4-SUBSTITUTED Quinoline Compounds As Sip Modulators
20 May 21
The invention relates to 1,2,3,4-substituted quinoline compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
Wilhelm AMBERG, Hervé GENESTE, Wilfried HORNBERGER, Udo LANGE, Mario MEZLER, Michael OCHSE, Frank OELLIEN, Sean C. TURNER, Jeroen VAN BERGEIJK, Elizabeth VAN DER KAM
Filed: 16 Jul 18
Utility
Methods for the Treatment of HER2 Amplified Cancer
20 May 21
Described herein are methods and compositions for treating HER2-amplified cancer.
Jun Chen, Joseph J. Buggy, Laurence Elias
Filed: 29 Jun 20
Utility
ANTI-CD71 Activatable Antibody Drug Conjugates and Methods of Use Thereof
20 May 21
The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
Shweta Singh, Jennifer Hope Richardson, Laura Patterson Serwer, Jonathan Alexander Terret, Susan E. Morgan-Lappe, Tracy Henriques, Sherry L. Ralston, Marvin Robert Leanna, Ilari Badagnani, Sahana Bose
Filed: 25 Nov 20
Utility
Modulators of ROR-gamma
18 May 21
David A. Claremon, Lawrence Wayne Dillard, Yi Fan, Lanqi Jia, Suresh B. Singh, Colin M. Tice, Zhenrong Xu, Jing Yuan, Linghang Zhuang
Filed: 17 Nov 16
Utility
Sleeve Containers for Packaging Medicinal Products
13 May 21
A blank of sheet material for forming a sleeve container, the blank of sheet material including two side panels each including a bottom edge and a top edge, and two elongated side panels arranged alternatingly with the side panels.
Guy C. Upchurch, James J. Hughes, Jovo Dragicevic
Filed: 9 Nov 20
Utility
Dihydropyrrolopyridine inhibitors of ROR-gamma
11 May 21
David A. Claremon, Lawrence Wayne Dillard, Chengguo Dong, Yi Fan, Stephen D. Lotesta, Andrew Marcus, Suresh B. Singh, Colin M. Tice, Jing Yuan, Wei Zhao, Linghang Zhuang
Filed: 25 Apr 19
Utility
Dosing Regimens for Use In Treating Myelofibrosis and Mpn-related Disorders with Navitoclax
6 May 21
The invention described herein relates to methods for treating a human subject with myelofibrosis or an MPN-related disorder, comprising administering navitoclax to the subject optionally in combination with ruxolitinib.
John Hayslip, Leanne M. Holes, Sven Mensing, Silpa Nuthalapati
Filed: 4 Nov 20
Utility
Bromodomain Inhibitors
6 May 21
David Hardee, Jason Brewer, Lisa Hasvold, Dachun Liu, Keith McDaniel, Michael Schrimpf, George Sheppard
Filed: 14 Apr 17
Utility
Nuclear Receptor Modulators
6 May 21
Maria A. Argiriadi, Eric C. Breinlinger, Kevin P. Cusack, Adrian D. Hobson, Dominique Potin, Martine Barth, Jerome Amaudrut, Olivia Poupardin, Laurent Mounier, Michael E. Kort
Filed: 16 Oct 19
Utility
Spiro-cyclic Amine Derivatives As S1P Modulators
6 May 21
Axel Stoit, Wouter I. Iwema Bakker, Hein K.A.C. Coolen, Maria J.P. van Dongen, Nicolas J.-L.D. Leflemme, Adrian Hobson
Filed: 31 Aug 20
Utility
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carb oxamide and solid state forms thereof
4 May 21
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.
Aileen L. Pangan, Henrique D. Teixeira, Mohamed-Eslam F. Mohamed, Ahmed A. Othman, Ben Klünder
Filed: 19 Dec 19
Utility
Combination therapy of a type II anti-CD20 antibody with a selective BCL-2 inhibitor
4 May 21
The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a CD20-expressing cancer.
Deepak Sampath, Christian Klein, Wayne John Fairbrother, Sari L. Heitner Enschede, Rod A. Humerickhouse, Andrew W. Roberts, John F. Seymour
Filed: 23 Mar 20
Utility
Methods of Treating and Preventing Graft Versus Host Disease
29 Apr 21
Described herein are methods for treating and preventing graft versus host disease using ACK inhibitors.
John C. Byrd, Jason A. Dubovsky, Natarajan Muthusamy, Amy J. Johnson, David Miklos
Filed: 12 Jun 20
Utility
Protein Formulations and Methods of Making Same
29 Apr 21
The invention provides an aqueous formulation comprising water and a protein, and methods of making the same.
Wolfgang Fraunhofer, Annika Bartl, Hans-Juergen Krause, Markus Tschoepe, Katharina Kaleta
Filed: 29 Dec 20
Utility
Modulators of the Integrated Stress Pathway
22 Apr 21
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
Carmela Sidrauski, Marina Pliushchev, Jennifer M. Frost, Lawrence A. Black, Xiangdong Xu, Ramzi Farah Sweis, Lei Shi, Qingwei I. Zhang, Yunsong Tong, Charles W. Hutchins, SeungWon Chung, Michael J. Dart
Filed: 28 May 20
Utility
Formulation of Human Antibodies for Treating Tnf-alpha Associated Disorders
22 Apr 21
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.
Hans-Juergen Krause, Lisa Baust, Michael Dickes
Filed: 18 Dec 20