126 patents
Page 2 of 7
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
18 May 23
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ
Filed: 20 Jan 23
Utility
Methods for Attaching Adapters to Sample Nucleic Acids
11 May 23
Methods of preparing double-stranded nucleic acids with single-stranded overhangs for amplification and sequencing are disclosed.
Andrew KENNEDY, Stefanie Ann Ward MORTIMER, AmirAli TALASAZ, Darya CHUDOVA, Helmy ELTOUKHY, Oliver ZILL, Richard B. LANMAN, Rebecca NAGY, Christine LEE, Kimberley BANKS
Filed: 28 Jun 22
Utility
Computer Architecture for Generating a Reference Data Table
4 May 23
An integrated data repository may be generated that includes genomics information and health insurance claims data information for a common group of individuals.
Naveen KUMAR, Jingwen ZHANG, Nisha SUBRAMANIAN, Gautam NAYAK, David HANNA, Shunxin LU
Filed: 30 Sep 22
Utility
Computer Architecture for Identifying Lines of Therapy
4 May 23
A computing machine accesses a pharmacy transaction data set and a medical procedure transaction data set.
Naveen KUMAR, Jingwen ZHANG, Nisha SUBRAMANIAN, Gautam NAYAK, Shunxin LU, Jiemin LIAO, Junhua YU
Filed: 29 Jul 22
Utility
Methods and Systems to Improve the Signal to Noise Ratio of Dna Methylation Partitioning Assays
27 Apr 23
In an aspect, the present disclosure provides a method for determining a methylation status comprises: providing a biological sample of nucleic acid molecules; partitioning at least a subset of the nucleic acid molecules in the biological sample based on the methylation status of the nucleic acid molecules into a plurality of partitioned sets; digesting at least a subset of the one or more partitioned sets in the plurality of partitioned sets with at least one methylation sensitive restriction enzyme; enriching at least a subset of the nucleic acid molecules in the plurality of partitioned sets for genomic regions of interest, wherein the at least a subset of the nucleic acid molecules comprises digested nucleic acid molecules in the one or more partitioned sets; and determining methylation status at one or more genetic loci of the nucleic acid molecules in at least one of the partitioned sets.
Andrew KENNEDY, William J. GREENLEAF
Filed: 22 Dec 22
Utility
Data Repository, System, and Method for Cohort Selection
6 Apr 23
A computer may access one or more medical data tables storing medical insurance transaction data for a plurality of patients.
Naveen KUMAR, Jingwen ZHANG, Nisha SUBRAMANIAN, Gautam NAYAK
Filed: 31 Aug 22
Utility
Homologous Recombination Repair Deficiency Detection
6 Apr 23
Provided herein are methods of generating a homologous recombination repair deficiency (HRD) score, determining a reference HRD score, determining a HRD status of a test subject having one or more cancer types, and/or treating a disease based on HRD status.
Jennifer YEN, Elena HELMAN, Arielle YABLONOVITCH
Filed: 28 Jun 22
Utility
Computer Architecture for Generating an Integrated Data Repository
6 Apr 23
An integrated data repository may be generated that includes genomics information and health insurance claims data information for a common group of individuals.
Naveen KUMAR, Jingwen ZHANG, Nisha SUBRAMANIAN, Gautam NAYAK, Kathryn LANG, Rajesh KUCHARLAPATI, Shunxin LU
Filed: 3 Jun 22
Utility
Methods for Early Detection of Cancer
16 Mar 23
Disclosed herein are methods, compositions, and devices for use in the early detection of cancer.
Stefanie Ann Ward MORTIMER, AmirAli TALASAZ, Darya CHUDOVA, Helmy ELTOUKHY
Filed: 19 Oct 22
Utility
Methods and Related Aspects for Analyzing Molecular Response
29 Dec 22
Provided herein are methods of determining a molecular response score.
Katie Julia QUINN, Allysia Jade MAK, Elena HELMAN, Tingting JIANG, Justin I. ODEGAARD, Darya CHUDOVA, Kyle Lik Ming CHANG, Han-Yu CHUANG, Daniel GAILE
Filed: 4 Mar 22
Utility
Locked Nucleic Acids for Capturing Fusion Genes
29 Dec 22
Provided herein is a method for enriching a sample for polynucleotides comprising a breakpoint of a fusion gene, comprising: a) contacting a probe set comprising a plurality of polynucleotide probes, each probe configured to specifically hybridize to a fusion gene, wherein the set comprises one or more high affinity polynucleotide probes (e.g., a polynucleotide comprising one or more locked nucleic acid nucleotides), with a mixture of polynucleotides under hybridization conditions to produce probe-captured polynucleotides; and b) isolating the probe-captured polynucleotides from the mixture, to produce a sample enriched with polynucleotides comprising breakpoint fragments of the fusion gene.
Stefanie Ann Ward MORTIMER
Filed: 14 Mar 22
Utility
Determining Cell Type Origin of Circulating Cell-free Dna with Molecular Counting
22 Dec 22
Provided herein are compounds, methods, and compositions for use in determining the cellular origin of circulating cell-free DNA.
Matthew William SNYDER
Filed: 28 Feb 22
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
8 Dec 22
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ, Stefanie Ann Ward MORTIMER
Filed: 22 Mar 22
Utility
Methods and Systems for Detecting Genetic Variants
1 Dec 22
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli TALASAZ, Helmy ELTOUKHY, Stefanie Ann Ward MORTIMER
Filed: 30 Jun 22
Utility
Cancer Evolution Detection and Diagnostic
10 Nov 22
The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state.
Helmy ELTOUKHY, AmirAli TALASAZ
Filed: 25 Jul 22
Utility
Methods to Determine Tumor Gene Copy Number by Analysis of Cell-free Dna
10 Nov 22
Methods are provided herein to improve automatic detection of copy number variation in nucleic acid samples.
Helmy Eltoukhy, AmirAli Talasaz, Darya Chudova, Diana Abdueva
Filed: 16 Dec 21
Utility
Use of Cell Free Bacterial Nucleic Acids for Detection of Cancer
27 Oct 22
Disclosed herein are compositions and methods for detecting the presence or absence of cancer or a specific cancer type in a subject.
Helmy ELTOUKHY
Filed: 8 Apr 22
Utility
Detecting the Presence of a Tumor Based on Off-target Polynucleotide Sequencing Data
27 Oct 22
In implementations described herein, information derived from a sample that is derived from off-target sequences can be used to determine estimates for the copy number of tumor cells and/or the tumor fraction of a sample.
Catalin BARBACIORU, Darya CHUDOVA, Aliaksandr ARTSIOMENKA, Daniel GAILE, Hao WANG
Filed: 9 Mar 22
Utility
Methods and Systems for Detecting Genetic Variants
13 Oct 22
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli TALASAZ, Helmy ELTOUKHY, Stefanie Ann Ward MORTIMER
Filed: 28 Jun 22
Utility
Methods for Computer Processing Sequence Reads to Detect Molecular Residual Disease
13 Oct 22
Disclosed herein are methods for use in detection of molecular residual disease.
Stefanie Ann Ward MORTIMER, AmirAli TALASAZ, Darya CHUDOVA, Helmy ELTOUKHY
Filed: 10 Jun 22