67 patents
Page 2 of 4
Utility
Methods and systems for analyzing nucleic acid molecules
6 Dec 22
The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins).
Andrew Kennedy, Stefanie Ann Ward Mortimer, Helmy Eltoukhy, AmirAli Talasaz
Filed: 24 Jun 19
Utility
Systems and methods to detect rare mutations and copy number variation
20 Sep 22
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 13 Oct 20
Utility
Methods for 3′ overhang repair
20 Sep 22
Methods of repairing a partially double-stranded DNA fragment are provided.
Eleen Shum
Filed: 23 Oct 20
Utility
Systems and methods to detect rare mutations and copy number variation
6 Sep 22
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 26 Jun 20
Utility
Methods and systems for detecting genetic variants
6 Sep 22
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy
Filed: 24 Aug 21
Utility
Methods of attaching adapters to sample nucleic acids
12 Jul 22
Methods of preparing double-stranded nucleic acids with single-stranded overhangs for amplification and sequencing are disclosed.
Andrew Kennedy, Stefanie Ann Ward Mortimer
Filed: 13 Apr 18
Utility
Methods for detecting single nucleotide variants or indels by deep sequencing
14 Jun 22
Disclosed herein are methods for use in detection of single nucleotide variants (SNVs) or indels.
Stefanie Ann Ward Mortimer, Amirali Talasaz, Darya Chudova, Helmy Eltoukhy
Filed: 21 Oct 21
Utility
Methods for computer processing sequence reads to detect molecular residual disease
31 May 22
Disclosed herein are methods for use in detection of molecular residual disease.
Stefanie Ann Ward Mortimer, AmirAli Talasaz, Darya Chudova, Helmy Eltoukhy
Filed: 2 Jul 21
Utility
Cancer evolution detection and diagnostic
17 May 22
The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state.
Helmy Eltoukhy, AmirAli Talasaz
Filed: 2 Feb 17
Utility
Systems and methods to detect rare mutations and copy number variation
3 May 22
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 8 Jul 21
Utility
Systems and methods to detect rare mutations and copy number variation
3 May 22
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 27 Jul 21
Utility
Cancer evolution detection and diagnostic
22 Mar 22
The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state.
Helmy Eltoukhy, AmirAli Talasaz
Filed: 3 Sep 20
Utility
Systems and methods to detect rare mutations and copy number variation
8 Feb 22
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 13 Oct 20
Utility
Methods to determine tumor gene copy number by analysis of cell-free DNA
8 Feb 22
Methods are provided herein to improve automatic detection of copy number variation in nucleic acid samples.
Helmy Eltoukhy, AmirAli Talasaz, Darya Chudova, Diana Abdueva
Filed: 8 Jan 20
Utility
Normalizing tumor mutation burden
7 Dec 21
Values for tumor mutation burden from different samples can be made more comparable to each other or control standards by a normalization regime that takes into account the minor allele fraction of highly rated mutations in a sample.
Darya Chudova
Filed: 4 May 20
Utility
Methods and systems for detecting genetic variants
19 Oct 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 31 Jul 20
Utility
Methods and systems for detecting genetic variants
19 Oct 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 4 Feb 21
Utility
Methods and systems for detecting genetic variants
14 Sep 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Stefanie Ann Ward Mortimer, Helmy Eltoukhy
Filed: 7 Jan 20
Utility
Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage
14 Sep 21
Provided herein are methods for detecting tumor mutational burden (TMB) in subjects.
Katie Julia Quinn, Elena Helman, Darya Chudova
Filed: 30 Jun 20
Utility
Systems and methods to detect rare mutations and copy number variation
17 Aug 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 14 Oct 20