109 patents
Utility
Heated Nanowells for Polynucleotide Synthesis
4 Jan 24
Devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein.
Eugene P. MARSH, Pierre F. INDERMUHLE, Bill James PECK
Filed: 30 Jun 23
Utility
Methylation-mediated Adapter Removal on Nucleic Acid Sequences
21 Dec 23
Provided herein are methods, systems, and compositions for efficient nucleic acid assembly with improved representation and distribution.
Siyuan CHEN, Xuan Yu Elian LEE, David LIN, Daniel J. RAMIREZ, Tavneet GILL, Patrick CHERRY, Esteban TORO
Filed: 6 Mar 23
Utility
Oligonucleic acid variant libraries and synthesis thereof
7 Nov 23
Disclosed herein are methods for the generation of highly accurate oligonucleic acid libraries encoding for predetermined variants of a nucleic acid sequence.
Anthony Cox, Sebastian Treusch, Siyuan Chen
Filed: 12 Oct 20
Utility
Devices and Methods for Oligonucleic Acid Library Synthesis
26 Oct 23
Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein.
William BANYAI, Bill James PECK, Andres FERNANDEZ, Siyuan CHEN, Pierre INDERMUHLE, Eugene P. MARSH
Filed: 17 May 23
Utility
Combinatorial Dna Assembly for Multispecific Antibodies
26 Oct 23
Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence.
Aaron SATO, Tom YUAN, Ana G. LUJAN HERNANDEZ, Rebecca NUGENT
Filed: 13 Feb 23
Utility
Methods and Devices for De Novo Oligonucleic Acid Assembly
19 Oct 23
Methods and devices are provided herein for surfaces for de novo nucleic acid synthesis which provide for low error rates.
Pierre F. INDERMUHLE, Eugene P. MARSH, Andres FERNANDEZ, William BANYAI, Bill J. PECK
Filed: 17 May 23
Utility
Compositions and Methods for Detection of Variants
12 Oct 23
Testing the many hypotheses from genomics and systems biology experiments demands accurate and cost-effective gene and genome synthesis.
Richard GANTT, Adriana ARNESON
Filed: 15 Dec 22
Utility
DICKKOPF-1 Variant Antibodies and Methods of Use
5 Oct 23
Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences.
Aaron SATO, Tom YUAN, Linya WANG, Fumiko AXELROD
Filed: 17 Nov 22
Utility
Heated nanowells for polynucleotide synthesis
5 Sep 23
Defined sequence RNA synthesis by 3′→5′ direction is now well established and currently in use for synthesis and development of vast variety of therapeutic grade RNA and Si RNA etc.
Eugene P. Marsh, Pierre F. Indermuhle, Bill James Peck
Filed: 15 Dec 20
Utility
Polynucleotides, reagents, and methods for nucleic acid hybridization
22 Aug 23
Provided herein are compositions, methods and systems relating to libraries of polynucleotides such that the libraries allow for accurate and efficient hybridization after binding to target sequences.
Ramsey Ibrahim Zeitoun, Siyuan Chen, Richard Gantt, Kristin D. Butcher, E. Hutson Chilton
Filed: 1 Oct 19
Utility
Bispecific SARS-COV-2 Antibodies and Methods of Use
17 Aug 23
Provided herein are methods and compositions relating to improved bispecific antibodies capable of binding and neutralizing SARS-CoV-2 variants.
Aaron SATO
Filed: 3 Jan 23
Utility
Methods and devices for de novo oligonucleic acid assembly
11 Jul 23
Methods and devices are provided herein for surfaces for de novo nucleic acid synthesis which provide for low error rates.
Pierre F. Indermuhle, Eugene P. Marsh, Andres Fernandez, William Banyai, Bill J. Peck
Filed: 21 Apr 20
Utility
De Novo Synthesized Gene Libraries
6 Jul 23
De novo synthesized large libraries of nucleic acids are provided herein with low error rates.
William BANYAI, Bill James PECK, Andres FERNANDEZ, Siyuan CHEN, Pierre INDERMUHLE
Filed: 16 Dec 22
Utility
Devices and methods for oligonucleic acid library synthesis
4 Jul 23
Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein.
William Banyai, Bill James Peck, Andres Fernandez, Siyuan Chen, Pierre Indermuhle, Eugene P. Marsh
Filed: 6 Jul 20
Utility
Devices and Methods for Synthesis
25 May 23
Provided herein are compositions, devices, systems and methods for DNA oligomer synthesis.
Jeremy LACKEY, David DODD, Stefan PITSCH
Filed: 31 Oct 22
Utility
Nucleic Acid Based Data Storage Using Enzymatic Bioencryption
18 May 23
Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage.
Bill James PECK, Ramsey Ibrahim ZEITOUN
Filed: 5 Dec 22
Utility
Methods and Compositions Relating to Continuous Sequencing
27 Apr 23
Provided herein are compositions, devices, systems and methods for polynucleotide sequencing.
Jeremy LACKEY, William BANYAI
Filed: 17 Oct 22
Utility
Methods and Compositions Relating to Covalently Closed Nucleic Acids
13 Apr 23
Provided herein are methods, systems, and compositions for assembly of covalently closed double stranded nucleic acids.
Rebecca NUGENT, Siyuan CHEN, Nathan RAYNARD
Filed: 18 Aug 22
Utility
Variant Nucleic Acid Libraries for Antibody Optimization
30 Mar 23
Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences.
Aaron SATO
Filed: 30 Sep 22
Utility
De Novo Synthesized Gene Libraries
23 Mar 23
De novo synthesized large libraries of nucleic acids are provided herein with low error rates.
William BANYAI, Bill James PECK, Andres FERNANDEZ, Siyuan CHEN, Pierre INDERMUHLE
Filed: 9 Aug 22