31 patents
Utility
Transdermal Delivery System with a Microporous Membrane Having Solvent-filledpores
18 Jan 24
A transdermal delivery system is described, where the system comprises a drug reservoir layer comprising an active agent and a skin contact adhesive layer.
Eun Soo Lee, Amit K. Jain, Parminder Singh
Filed: 11 Apr 23
Utility
Systems and methods for long term transdermal administration
16 May 23
Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.
Eun Soo Lee, Amit K. Jain, Parminder Singh
Filed: 9 Oct 20
Utility
Adhesive Matrix with Hydrophilic and Hydrophobic Domains and a Therapeutic Agent
11 May 23
An adhesive matrix and adhesive formulation are described.
Eun Soo Lee, Amit K. Jain, Parminder Singh
Filed: 29 Nov 22
Utility
Methods and compositions for treatment with donepezil
23 Mar 23
A method for delivering a therapeutic agent to a subject from a transdermal delivery system is described, where the therapeutic agent (i) has a half-life in the blood when delivered orally of greater than about 48 hours and (ii) is for the treatment of a chronic condition.
Parminder Singh, Eun Soo Lee, Amit K. Jain
Filed: 28 Nov 22
Utility
Combination Therapy Treatment Using Transdermal Delivery System
9 Mar 23
The present disclosure provides a transdermal delivery system for treating Alzheimer’s disease with donepezil, optionally in combination with a second therapeutic agent such as aducanumab.
Eun Soo Lee, Mark Claypool, Jacob Karhoff, Jarrod Bento, Dustin Moseley
Filed: 27 Jun 22
Utility
Corona Discharge Treated Transdermal Delivery System
2 Feb 23
The present disclosure provides a transdermal delivery systems for delivering donepezil free base to patients suffering from central nervous system disorders including dementia and Alzheimer's.
Eun Soo Lee, Mark Claypool, Jacob Karhoff, Jarrod Bento, Dustin Moseley
Filed: 27 Jun 22
Utility
Method and Device for Transdermal Delivery of Parathyroid Hormone Using a Microprojection Array
26 Jan 23
A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
Parminder Singh, Danir Bayramov, Guohua Chen, Robert Wade Worsham
Filed: 15 Jul 22
Utility
Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
3 Jan 23
An adhesive matrix and adhesive formulation are described.
Eun Soo Lee, Amit K. Jain, Parminder Singh
Filed: 23 Jun 17
Utility
Method and device for transdermal delivery of parathyroid hormone using a microprojection array
23 Aug 22
A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
Parminder Singh, Danir Bayramov, Guohua Chen, Robert Wade Worsham
Filed: 10 Feb 20
Utility
Methods for Treating Alzheimer's Disease with Donepezil Transdermal System
20 Jan 22
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt.
Eun Soo LEE, Amit K. JAIN, Parminder SINGH
Filed: 5 Aug 21
Utility
Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
16 Nov 21
Methods, compositions, and devices for transdermally administering an active agent such as memantine are provided.
Eun Soo Lee, Parminder Singh, Appala Sagi, Amit K. Jain
Filed: 20 Dec 18
Utility
Hybrid Method of Forming Microstructure Array Molds, Methods of Making Microstructure Arrays, and Methods of Use
9 Sep 21
A method of forming a master mold (52), comprising: a) forming a plurality of microstructure portions (42) in a substrate formed of a first material by a first micromachining process, each microstructure portion comprising a shaft (40) and a distal tip (38); b) in preparing a negative mold (46) of the plurality of microstructure portions, wherein the mold is formed of a second material and comprises a plurality of cavities (48) corresponding to each microstructure portion in the plurality of microstructure portions (42); c) electroplating a metal (50) onto the negative mold to fill each cavity in the plurality of cavities and to form abase layer (54) extending from the negative mold; d) forming a proximal section (56) for each of the microstructures in the base layer using a second micromachining process (e.g. mechanical micromachining); and e) before or after said step d), removing the negative mold from the metal to form a master mold.
Ashutosh SHASTRY, Wesley CHANG, Parminder SINGH
Filed: 25 Jun 19
Utility
Microprojection applicators and methods of use
7 Sep 21
Applicators for a microprojection array and methods of using the applicators are described.
Anthony Le, Doug Bourne, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
Filed: 25 Feb 19
Utility
Methods for treating alzheimer's disease with donepezil transdermal system
31 Aug 21
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt.
Eun Soo Lee, Amit K. Jain, Parminder Singh
Filed: 23 Apr 19
Utility
Microarray for delivery of therapeutic agent and methods of use
6 Jul 21
Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.
Zhongli Ding, Guohua Chen, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
Filed: 20 Dec 13
Utility
Systems Comprising a Composite Backing and Methods for Long Term Transdermal Administration
1 Jul 21
Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.
Eun Soo Lee, Amit K. Jain, Parminder Singh
Filed: 12 Mar 21
Utility
Applicators for Microneedles
24 Jun 21
An applicator for a microprojection array is described.
Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
Filed: 25 Feb 21
Utility
Systems comprising a composite backing and methods for long term transdermal administration
6 Apr 21
Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.
Eun Soo Lee, Amit K. Jain, Parminder Singh
Filed: 30 Dec 16
Utility
Medical Device Packaging
25 Mar 21
A packaging system providing for sterile enclosure of devices including medical devices and systems such as delivery systems is described.
Adrian L. Faasse, Parminder Singh
Filed: 2 Oct 20
Utility
Memantine transdermal delivery systems
16 Mar 21
Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer, optionally together with one or more intermediate and/or supporting layers, wherein the drug reservoir layer comprises an acrylate polymer or copolymer, a permeation enhancer, a carrier, and memantine base generated in situ by reaction of a memantine salt and an alkaline salt.
Eun Soo Lee, Parminder Singh, Appala Sagi, Amit K. Jain
Filed: 26 Jul 17