8 patents
Utility
Compositions of Ajulemic Acid and Uses Thereof
26 Oct 23
The invention relates to crystalline forms of (6aR,10aR)-1-Hydroxy-6, 6-dimethyl-3-(2-methyl-2-octanyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene-9-carboxylic acid (ajulemic acid), including pharmaceutical compositions comprising a crystalline form of ajulemic acid and methods of making a crystalline form of ajulemic acid.
David Richard BOOTH, Chaoyi DENG, Robert Paul DISCORDIA, Feng GUO, Clifton David LEIGH, Kristos Adrian MOSHOS, Hayley Ann REECE, Abdolsamad TADAYON, Tingting XU, Hang ZHANG
Filed: 9 Oct 20
Utility
Ultrapure TETRAHYDROCANNABINOL-11-OIC Acids
21 Apr 22
This application is in the field of medicinal chemistry and relates to ultrapure ajulemic acid, its synthesis, pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of inflammation, pain, and fibrotic diseases including scleroderma, systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, idiopathic pulmonary fibrosis, Dupuytren's contracture, keloids, chronic kidney disease, chronic graft rejection, and other scarring-wound healing abnormalities, post-operative adhesions, and reactive fibrosis.
Mark TEPPER, Dean A. FREY, David GOEDDEL, Karl E. REINEKE
Filed: 2 Jun 21
Utility
Lipoxin A4 Analogs and Uses Thereof
30 Dec 21
The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11-(4-fluorophenoxy)-1,10-dihydroxyundeca-2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4).
Nan CHIANG, Sheldon N. CRANE, Thomas JENNEQUIN, Valdas JURKAUSKAS, Clifton D. LEIGH, Kristos Adrian MOSHOS, Charles N. Serhan, Mark A. Tepper, Yuhua George Zhang
Filed: 23 Oct 19
Utility
Cannabinoids and Uses Thereof
16 Sep 21
The invention relates to cannabinoid compounds, pharmaceutical compositions including one or more cannabinoid compounds, and the use of pharmaceutical compositions including one or more cannabinoid compounds for the treatment of a disease or condition (e.g., a fibrotic disease or an inflammatory disease) in a subject in need thereof.
Kristos Adrian MOSHOS, Clifton D. LEIGH, Yuhua George ZHANG, Mark TEPPER, Hongfeng DENG
Filed: 31 May 19
Utility
Ultrapure tetrahydrocannabinol-11-oic acids
6 Jul 21
This application is in the field of medicinal chemistry and relates to ultrapure ajulemic acid, its synthesis, pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of inflammation, pain, and fibrotic diseases including scleroderma, systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, idiopathic pulmonary fibrosis, Dupuytren's contracture, keloids, chronic kidney disease, chronic graft rejection, and other scarring-wound healing abnormalities, post-operative adhesions, and reactive fibrosis.
Mark Tepper, Dean A. Frey, David Goeddel, Karl E. Reineke
Filed: 29 May 19
Utility
Methods and Compositions Relating to Ultrapure 5-(1,1-DIMETHYLHEPTYL)-RESORCINOL
1 Jul 21
The invention provides methods and compositions relating to an ultrapure formulation of 5-(1,1-dimethylheptyl)-resorcinol (ultrapure DMHR).
Valdas JURKAUSKAS, Kristos Adrian MOSHOS, Clifton D. LEIGH, Feng SHI, Xiaofeng CHEN, Chengfu XIE
Filed: 19 Oct 18
Utility
Methods for the Treatment of Infection
30 Dec 20
The invention provides methods for treating an infection in a subject in need thereof by administering to the subject a pharmaceutical composition including ajulcmic acid, or a pharmaceutically acceptable salt thereof.
Mark A. TEPPER, Derek W. GILROY, Madhur MOTWANI, Tracey L. BONFIELD
Filed: 30 Jan 20
Utility
Ultrapure TETRAHYDROCANNABINOL-11-OIC Acids
25 Mar 20
This application is in the field of medicinal chemistry and relates to ultrapure ajulemic acid, its synthesis, pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of inflammation, pain, and fibrotic diseases including scleroderma, systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, idiopathic pulmonary fibrosis, Dupuytren's contracture, keloids, chronic kidney disease, chronic graft rejection, and other scarring-wound healing abnormalities, post-operative adhesions, and reactive fibrosis.
Mark TEPPER, Dean A. FREY, David GOEDDEL, Karl E. REINEKE
Filed: 28 May 19
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