6 patents
Utility
Compounds for Use In Anti-cancer Immunotherapy
21 Jul 22
The present disclosure relates to the reversal of T cell exhaustion using aplysiatoxin analogs or PKC theta agonist compounds for anti-cancer immunotherapy.
Steven Bruce Cohen, Dan Lu, Farhana Barmare, Ippei Usui, Venkata Rami Reddy Macherla, Elizabeth Paige Stout, Jacob Neal Beverage, Eduardo Esquenazi, Peter A. Jordan, Phil S. Baran, John R. Teijaro
Filed: 28 May 20
Utility
Cyclic Peptide Analogs and Conjugates Thereof
21 Jul 22
Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
Ippei USUI, Bryan Junn LEE, Steven Bruce COHEN, Venkat Rami Reddy MACHERLA, Jacob Neal BEVERAGE, Chung-Mao PAN, Farhana BARMARE, Eduardo ESQUENAZI
Filed: 22 Dec 21
Utility
Cyclic peptide analogs and conjugates thereof
22 Feb 22
Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
Ippei Usui, Bryan Junn Lee, Steven Bruce Cohen, Venkat Rami Reddy Macherla, Jacob Neal Beverage, Chung-Mao Pan, Farhana Barmare, Eduardo Esquenazi
Filed: 31 Aug 17
Utility
Anti-cancer Compounds and Conjugates Thereof
7 Oct 20
Disclosed herein are compounds, drug-conjugates thereof, methods of preparing drug-conjugates, and uses thereof.
Oliver Booth Vining, Venkata Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Jacob Neal Beverage, Elizabeth Paige Stout, Bryan Junn Lee, Steven Bruce Cohen, Eduardo Esquenazi
Filed: 17 Jun 20
Utility
Anti-cancer compounds and conjugates thereof
27 Jul 20
Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof.
Oliver Booth Vining, Venkata Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Jacob Neal Beverage, Elizabeth Paige Stout, Bryan Junn Lee, Steven Bruce Cohen, Eduardo Esquenazi
Filed: 26 Sep 16
Utility
Cyclic peptide analogs and conjugates thereof
11 Nov 19
Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
Venkat Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Elizabeth Paige Stout, Jacob Neal Beverage, Bryan Junn Lee, Steven Bruce Cohen
Filed: 2 Mar 16
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