116 patents
Page 6 of 6
Utility
Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish
6 Jan 20
The present invention relates to a new generation of chimeric antigen receptors (CAR), under single-chain or multi-chain forms, the specificity of which, to a desired antigen, is conferred by a VNAR polypeptide derived from monomeric antibodies from cartilaginous fish.
Philippe Duchateau, Julien Valton
Filed: 13 Jan 15
Utility
Methods for Altering Amino Acid Content In Plants
1 Jan 20
Materials and methods are provided for making plants (e.g., soybean varieties, wheat varieties, or corn varieties) with altered amino acid content.
Song Luo, Benjamin Clasen, Feng Zhang, Nicholas J. Baltes, Javier Gil Humanes
Filed: 29 Aug 17
Utility
Use of pre T alpha or functional variant thereof for expanding TCR alpha deficient T cells
30 Dec 19
A method of expanding TCRalpha deficient T-cells by expressing pTalpha or functional variants thereof into said cells, thereby restoring a functional CD3 complex.
Roman Galetto, Agnes Gouble, Stephanie Grosse, Cecile Mannioui, Laurent Poirot, Andrew Scharenberg, Julianne Smith
Filed: 21 Mar 19
Utility
Bcma (CD269) Specific Chimeric Antigen Receptors for Cancer Immunotherapy
25 Dec 19
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells.
Roman GALETTO
Filed: 7 May 19
Utility
Potatoes with reduced cold-induced sweetening
23 Dec 19
Materials and methods are provided for making Solanum varieties with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
Luc Mathis, Daniel F. Voytas, Feng Zhang, Benjamin Clasen, William Haun, Thomas Stoddard
Filed: 19 Dec 13
Utility
Rare-cutting endonucleases for efficient and specific targeting DNA sequences comprising highly repetitive motives
16 Dec 19
The present invention is in the field of genetic editing tools and methods of genetic engineering.
Philippe Duchateau, Alexandre Juillerat
Filed: 23 Oct 14
Utility
Dynamic mixing and electroporation chamber and system
2 Dec 19
An electroporation apparatus and its novel chamber with inlet ports for mixing cells and exogenous material.
Alan D King, Richard E Walters, Stephen B Deitz, Donald J Rodis, Jr., Derin C Walters
Filed: 10 May 11
Utility
CS1 Specific Multi-chain Chimeric Antigen Receptor
27 Nov 19
The present invention relates to a new generation of chimeric antigen receptors (CAR) referred to as multi-chain CARs, which are made specific to the antigen CS1.
Roman Galetto
Filed: 25 Mar 19
Utility
Altering Expression of Gene Products In Plants Through Targeted Insertion of Nucleic Acid Sequences
27 Nov 19
Materials and methods for changing expression of a gene product in a plant are provided, and in an embodiment for creating herbicide tolerant plants are described herein.
Nicholas Baltes
Filed: 27 Jun 17
Utility
Modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins
11 Nov 19
The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont Burkholderia Rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.
Claudia Bertonati, Philippe Duchateau, Alexandre Juillerat, George Silva, Julien Valton
Filed: 26 Apr 15
Utility
Method for modulating car-induced immune cells activity
11 Nov 19
The present invention relates to a method to modulate the level of activation of an engineered immune cell (such as a Chimeric Antigen Receptor T-cell) for immunotherapy.
Philippe Duchateau, Alexandre Juillerat, Laurent Poirot
Filed: 6 Oct 15
Utility
Method to Overcome Dna Chemical Modifications Sensitivity of Engineered Tale Dna Binding Domains
6 Nov 19
The present invention relates to polypeptides and more particularly to Transcription Activator-Like Effector derived proteins that allow to efficiently target and/or process nucleic acids.
Philippe DUCHATEAU, Julien VALTON
Filed: 8 Apr 19
Utility
Cell Death Inducing Chimeric Antigen Receptors
6 Nov 19
The invention relates to cell death inducing chimeric antigen receptors (D-CAR).
Alexandre JUILLERAT, Philippe DUCHATEAU, Laurent POIROT, Murielle DERRIEN, Donna Marie STONE, Javier Fernando CHAPARRO RIGGERS
Filed: 18 Oct 17
Utility
a Method of Engineering Prodrug-specific Hypersensitive T-cells for Immunotherapy by Gene Expression
30 Oct 19
The present invention relates to therapeutic cells for immunotherapy to treat patients with cancer.
Julien VALTON, Philippe DUCHATEAU, Laurent POIROT, Barbra Johnsson SASU, Arvind RAJPAL
Filed: 12 Apr 17
Utility
Tale-protein Scaffolds and Uses Thereof
16 Oct 19
The present invention relates to new Transcription Activator-Like Effector proteins and more particularly new Transcription Activator-Like Effector Nucleases (TALENs) that can efficiently target and process nucleic acids.
Philippe Duchateau, Alexandre Juillerat, Julien Valton, Claudia Bertonati, Jean-Charles Epinat, George H. Silva
Filed: 1 Jan 19
Utility
Use of preTalpha or functional variant thereof for expanding TCRalpha deficient T cells
30 Sep 19
A method of expanding TCRalpha deficient T-cells by expressing pTalpha or functional variants thereof into said cells, thereby restoring a functional CD3 complex.
Roman Galetto, Agnes Gouble, Stephanie Grosse, Cecile Mannioui, Laurent Poirot, Andrew Scharenberg, Julianne Smith
Filed: 12 May 13