2 patents
Utility
Cyclodextrin-panobinostat adduct
27 Jul 20
The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct.
Tom Coulter, Stephen Damment, Alessandro Pace, Daniel Palmer
Filed: 28 Mar 17
Utility
Nanoparticles and their use in cancer therapy
22 Jun 20
The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject.
Jon Golding, Phillip Williams, Meike Roskamp
Filed: 21 Dec 15
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