168 patents
Utility
Method for Classifying an Input Image Representing a Particle In a Sample
18 Jan 24
A method for classifying at least one input image representing a target particle in a sample, involves implementing, by data processing of a client, steps of: (b) extracting the characteristic map of the target particle by a convolutional neural network pre-trained on a base of public images; (c) classifying the input image according to the extracted characteristic map.
Pierre MAHÉ, Meriem EL AZAMI, Elodie DEGOUT-CHARMETTE, Zohreh SEDAGHAT, Quentin JOSSO, Fabian ROL
Filed: 19 Oct 21
Utility
Method for Analysing a Biological Sample Comprising Determination of the Spatial Distribution of Biomass along the Optical Axis
18 Jan 24
A method of analyzing a biological sample including biological agents and disposed in an analysis receptacle in a field of view of a holographic imaging system defining an acquisition focal plane, including, for each of a plurality of measurement times: acquiring a plurality of holographic images of the biological sample at different respective positions of the acquisition focal plane, and, from each acquired holographic image, determining a value of a biomass parameter representative of the quantity of biological agents at the position of the acquisition focal plane, the method including constructing a distribution indicator from values of the biomass parameter at the same measurement time for a plurality of positions of the acquisition focal plane, and providing, among the analysis results, a representation of the distribution of the biomass of biological agents, derived from at least one distribution indicator at a measurement time.
Dominique DECAUX, Emilie BISCEGLIA
Filed: 23 Sep 21
Utility
Use of Torque Teno Virus (TTV) As a Marker to Determine the Proliferative Capacity of T Lymphocytes
11 Jan 24
The subject matter is a method for determining the proliferation capacity of T lymphocytes in a subject, the method including the following steps: a) measuring the load of torque teno virus from a biological sample of the subject; and b) determining the proliferative capacity of the T lymphocytes based on the viral load measured in a).
Karen BRENGEL-PESCE, Sophie ASSANT-TROUILLET, William MOUTON
Filed: 4 Nov 21
Utility
Digital Holographic Imaging Technique with Twin Image Elimination
21 Dec 23
A digital holographic imaging technique, includes iterative steps of: a) through back-propagation to the object coordinate of a hologram field comprising a spatial distribution of amplitude corresponding to the spatial distribution of intensity of the hologram and a spatial distribution of phase, determining an object field involving a spatial distribution of absorption and of phase shift of the imaged object, b) thresholding the values of the spatial distribution of absorption and of phase shift by decreasing the values to below a respective threshold, the thresholds decreasing in each iteration, c) through repropagation of the object field to the hologram coordinate, determining a modified hologram field comprising a modified spatial distribution of amplitude and a modified spatial distribution of phase, d) replacing the spatial distribution of phase of the hologram field with the modified spatial distribution of phase, the spatial distribution of phase shift and of absorption of the imaged object being those of the object field of the last iteration.
Zohreh SEDAGHAT, Quentin JOSSO, Fabian ROL
Filed: 19 Oct 21
Utility
Method for Classifying an Input Image Containing a Particle In a Sample
30 Nov 23
A method for classifying at least one input image containing a target particle in a sample, involves implementing, via data-processing of a client, steps of: (b) extracting a vector of characteristics of the target particle, the characteristics being numerical coefficients each associated with one elementary image of a set of elementary images each representing a reference particle, such that a linear combination of the elementary images weighted by the coefficients approximates the representation of the target particle in the input image; (c) classifying the input image depending on the extracted vector of characteristics.
Pierre MAHÉ, Meriem EL AZAMI, Elodie DEGOUT-CHARMETTE, Zohreh SEDAGHAT, Quentin JOSSO, Fabian ROL
Filed: 19 Oct 21
Utility
Method for Classifying an Input Image Representing a Particle In a Sample
30 Nov 23
A method for classifying at least one input image representing a target particle in a sample involves implementing, by data processing a client, steps of: (B) extracting a characteristic map of the target particle from the input image; (c) reducing the number of variables in the extracted characteristic map, using the t-SNE algorithm; (d) classifying, unsupervised, the input image based on the characteristic map having a reduced number of variables.
Pierre MAHÉ, Meriem EL AZAMI, Elodie DEGOUT-CHARMETTE, Zohreh SEDAGHAT, Quentin JOSSO, Fabian ROL
Filed: 19 Oct 21
Utility
Method for Classifying a Sequence of Input Images Representing a Particle In a Sample Over Time
30 Nov 23
A method for classifying a sequence of input images representing a target particle in a sample over time, includes the following steps performed by the data processing of a client, namely: (b) concatenation of the input images in the sequence as a three-dimensional stack; (c) direct classification of the three-dimensional stack using a convolutional neural network, CNN
Pierre MAHÉ, Meriem EL AZAMI, Elodie DEGOUT-CHARMETTE, Zohreh SEDAGHAT, Quentin JOSSO, Fabian ROL
Filed: 19 Oct 21
Utility
Method for diagnosis and/or prognosis of a septic syndrome
21 Nov 23
Disclosed herein is a method for the diagnosis/prognosis of a septic syndrome based on a biological sample from a patient.
Alexandre Pachot, Guillaume Monneret, Alain Lepape
Filed: 12 Mar 21
Utility
Sample Test Cards
26 Oct 23
The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples.
Bruno Colin, Raymond O’Bear, Cecile Paris
Filed: 29 Jun 23
Utility
Method for Analyzing a Biological Sample Comprising an Initial Compliance Analysis
26 Oct 23
Systems and methods for determining a topology for a multi-path connection based on one or more application-level wherein, a method performed by a master topology function includes receiving a request for a topology for a multi-path connection that satisfies an application-level requirement(s) of a particular application and determining a topology for the multi-path connection based on the application-level requirement(s).
Dominique DECAUX, Emilie BISCEGLIA, Guillaume PERRIN
Filed: 23 Sep 21
Utility
Optical density instrument and systems and methods using the same
10 Oct 23
Instruments, systems, and methods for measuring optical density of microbiological samples are provided.
Perry D. Stamm, Joel Patrick Harrison, Gregory R Maes, Jeffrey Edward Price, Jack R. Hoffmann, Jr., John Kenneth Korte, Daniel Joseph Pingel, Walter J. Clynes, Sean Gregory Furman, Leonard H. Schleicher, Christopher George Kocher, Brian David Peterson, Jacky S. Yam
Filed: 9 Sep 21
Utility
Method for Analysing a Biological Sample with Artefact Masking
14 Sep 23
A method for analysing a biological sample by means of an analysis instrument, the sample including biological agents and being arranged in an analysis receptacle in view of a holographic imaging system, the method including: acquiring a holographic image of the sample, the holographic image associating an intensity value with each pixel, determining, from the image acquired, an image mask which associates an active or inactive state with each pixel in accordance with the intensity values so that an inactive state is associated with pixels which correspond to artefacts caused by elements present in the field of view other than biological agents, determining a value of at least one biomass parameter which represents the quantitative spatial distribution of biological agents in the field of view, using only the pixels of the holographic image having an active state, and supplying the value of the biomass parameter from the analysis results.
Dominique DECAUX, Emilie BISCEGLIA, Guillaume PERRIN, Philippine BARLAS, Emilie COLLIGNON
Filed: 23 Sep 21
Utility
Method for measuring the plasma concentration of an analyte directly on a whole blood sample
5 Sep 23
A method of measuring an analyte amount in a whole blood sample, including (i) measuring the haematocrit level of the whole blood sample; (ii) measuring an analyte amount directly in the whole blood sample; and (iii) calculating a corrected analyte amount according to relation DP=Pa(DST, DH), where Dp, is the corrected analyte amount, DST is the measured analyte amount, DH is the measured haematocrit level, and Pa is a non-constant polynomial of a degree greater than or equal to 1 having as indeterminate values the measured analyte amount, DST, and the measured haematocrit level, DH, and having its polynomial coefficients depending on the analyte.
Sylvie Cheucle, Laure Marillet, Aurélie Thollet
Filed: 24 Oct 18
Utility
Sample test cards
22 Aug 23
The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples.
Bruno Colin, Raymond O'Bear, Cecile Paris
Filed: 18 Feb 19
Utility
Focus Adjustment Method For Holographic Imaging System
27 Jul 23
Nicolas Faure, Frédéric Pinston, Corinne Fournier, Loïc Denis, Thomas Olivier
Filed: 23 Jun 21
Utility
Methods for confirming charged-particle generation in an instrument, and related instruments
2 May 23
Methods for confirming charged-particle generation in an instrument are provided.
James Arthur VanGordon
Filed: 25 Jan 21
Utility
Methods for aligning a light source of an instrument, and related instruments
14 Mar 23
Methods for an instrument including a light source of are provided.
Ian MacGregor, Scott Collins, Jo-ann Loh, Spencer Lovette, Andrew J. Violette, James VanGordon, Jared Bullock
Filed: 12 Mar 19
Utility
Assay devices and methods of manufacture
28 Feb 23
Systems, methods, and apparatuses are provided for self-contained nucleic acid preparation, amplification, and analysis.
Aaron Wernerehl, Jonathan A. Bruns, Jonathan B. Derrick, Taylor S. Zimmerman, David E. Jones
Filed: 28 Oct 20
Utility
Sample handling systems, mass spectrometers and related methods
28 Feb 23
Slide analysis a gripper with three sensors for controlling a slide grip sequence and at least one rotatable carousel with a slide receiving channel.
Jared Bullock, Scott Collins, Ian MacGregor, Mark Talmer
Filed: 10 May 21
Utility
Method for identifying by mass spectrometry an unknown microorganism subgroup from a set of reference subgroups
24 Jan 23
A method for identifying by mass spectrometry an unknown microorganism subgroup among a set of reference subgroups, including a step of constructing one knowledgebase and one classifying model per associated subgroup on the basis of the acquisition of at least one set of learning spectra of microorganisms identified as belonging to the subgroups of a group and including: constructing an adjusting model allowing mass-to-charge offsets of the acquired spectra to be corrected on the basis of reference masses-to-charges that are common to the various subgroups; adjusting the masses-to-charges of all of the lists of peaks of the learning spectra and constructing one classifying model per subgroup and the associated knowledgebase on the basis of the adjusted learning spectra.
Maud Arsac, Pierre-Jean Cotte-Pattat, Victoria Girard, Valérie Monnin
Filed: 21 Apr 16