23 patents
Utility
Crispr Sam Biosensor Cell Lines and Methods of Use Thereof
4 Jan 24
Disclosed are cell lines that stably express CRISPR SAM complex which comprise a gRNA that specifically targets a promoter of a gene, wherein the gene is not normally expressed in said cell.
Meghan DRUMMOND SAMUELSON, Leah SABIN, Sarah CANCELARICH
Filed: 2 Dec 21
Utility
Hypertonic pharmaceutical compositions containing an anti-platinum chemoprotectant agent
2 Jan 24
Hypertonic pharmaceutical compositions are disclosed.
Qi-Ying Hu, John Lee, Fuxin Shi
Filed: 21 Jun 21
Utility
2gbqgc4g1zndkmdqoycrf1pvh54l4amfapmzti1dvijb4z7hxuqsw37etpm
4 Jul 23
Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof.
John Lee, John R. Soglia, Qi-Ying Hu, Fuxin Shi
Filed: 26 Oct 20
Utility
c56ag3fkuotnpsie9lxbj2hn97zt55m5llvpfz77j7den117bak2
30 May 23
The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with mutations in otoferlin (OTOF), by way of OTOF gene therapy.
Joseph Burns, Kathryn Ellis, Adam Palermo, Martin Schwander, Jonathon Whitton
Filed: 26 Apr 19
Utility
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2 Mar 23
The disclosure provides Sox2 inhibitors that can be used to generate Type I vestibular hair cells in the vestibular system.
Joseph BURNS, Noah DRUCKENBROD, Tyler GIBSON, Ryan MCCARTHY, Jonathan B. SELLON, Kathy SO
Filed: 22 Jan 21
Utility
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3 Nov 22
The disclosure provides polynucleotides containing inner hair cell-specific promoters, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in inner hair cells.
Joseph BURNS, Adam PALERMO, Gabriela PREGERNIG, Martin SCHWANDER
Filed: 2 May 22
Utility
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20 Oct 22
The disclosure provides polynucleotides containing SLC6A14 promoters, as well as vectors containing the same, that can be used to promote expression of a transgene in vestibular supporting cells.
Joseph BURNS, Tyler GIBSON, Gabriela PREGERNIG
Filed: 3 May 22
Utility
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11 Oct 22
This disclosure relates to methods for expanding inner ear supporting cells (e.g., Lgr5+ inner ear supporting cells) and differentiating inner ear supporting cells (e.g., Lgr5+ inner ear supporting cells) to inner ear hair cells (e.g., atonal homolog 1 (Atoh1)+ inner ear hair cells) and the use of the inner hear supporting cells and hair cells, e.g., for identifying candidate therapeutic compounds for the treatment of hearing loss and balance loss.
Albert Edge, Michael Venuti, Agnieszka Czechowicz
Filed: 27 Jan 17
Utility
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15 Sep 22
The disclosure provides polynucleotides containing outer hair cell-specific promoters, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in outer hair cells.
Joseph BURNS, Martin SCHWANDER, XuDong WU
Filed: 3 May 22
Utility
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25 Aug 22
The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with a mutation in otoferlin (OTOF), by way of OTOF gene therapy.
Joseph BURNS, Kathryn ELLIS, Tyler GIBSON, Adam PALERMO, Martin SCHWANDER, Jonathon WHITTON, Leah SABIN, Christos KYRATSOUS, Meghan DRUMMOND SAMUELSON
Filed: 29 Apr 22
Utility
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24 Feb 22
The invention provides compositions and methods containing alpha-helical polypeptides as permeation enhancers for effectuating the passage of therapeutic agents into the inner ear by passage through the round window membrane.
Qi-Ying HU, John LEE, Paul H. LIEBESNY, Changsuk MOON, Yong REN
Filed: 11 Dec 19
Utility
6e32w7o5gvu2205t2fyy045uhusy7ud4y
23 Dec 21
The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with mutations in otoferlin (OTOF), by way of OTOF gene therapy.
Joseph BURNS, Kathryn ELLIS, Adam PALERMO, Martin SCHWANDER, Jonathon WHITTON, Leah SABIN, Christos KYRATSOUS, Meghan DRUMMOND SAMUELSON
Filed: 6 Aug 21
Utility
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16 Dec 21
The disclosure provides polynucleotides containing regions of the Myosin 15 (Myo15) promoter, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in hair cells.
Joseph BURNS, Kathryn ELLIS, Adam PALERMO, Martin SCHWANDER, Jonathon WHITTON, Leah SABIN, Christos KYRATSOUS, Meghan DRUMMOND SAMUELSON
Filed: 6 Aug 21
Utility
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18 Nov 21
The invention provides AAV1 vectors that can be used to transduce multiple inner ear cell types and their use for treatment of hearing loss, deafness, tinnitus, and vestibular dysfunction.
Joseph BURNS, Kathryn ELLIS, Matthew NGUYEN, Adam PALERMO, Gabriela PREGERNIG, Fuxin SHI, Jonathon WHITTON
Filed: 11 Oct 19
Utility
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7 Oct 21
Hypertonic pharmaceutical compositions are disclosed.
Qi-Ying HU, John LEE, Fuxin SHI
Filed: 21 Jun 21
Utility
5wkgoq2tx4p4yq9qqq971zbaqbge
5 Aug 21
The disclosure provides polynucleotides containing regions of the Myosin 15 (Myo15) promoter, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in hair cells.
Joseph BURNS, Kathryn ELLIS, Adam PALERMO, Martin SCHWANDER, Jonathon WHITTON
Filed: 26 Apr 19
Utility
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27 Jul 21
Hypertonic pharmaceutical compositions are disclosed.
Qi-Ying Hu, John Lee, Fuxin Shi
Filed: 13 Jul 20
Utility
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11 Feb 21
Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof.
John LEE, John R. SOGLIA, Qi-Ying HU, Fuxin SHI
Filed: 26 Oct 20
Utility
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28 Oct 20
Hypertonic pharmaceutical compositions are disclosed.
Qi-Ying HU, John LEE, Fuxin SHI
Filed: 12 Jul 20
Utility
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26 Oct 20
Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof.
John Lee, John R. Soglia, Qi-Ying Hu, Fuxin Shi
Filed: 30 May 19