42 patents
Utility
Extracellular Vesicle-aso Constructs Targeting STAT6
16 Nov 23
The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a STAT6 transcript.
Tim SOOS, Sushrut KAMERKAR, Su Chul JANG, Kyriakos ECONOMIDES, Dalia BURZYN
Filed: 6 Oct 21
Utility
Methods and Compositions for Macrophage Polarization
16 Nov 23
Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages.
Sriram SATHYANARAYANAN, Douglas E. WILLIAMS, Dalia BURZYN, Adam Thomas BOUTIN, Sushrut KAMERKAR
Filed: 4 Nov 22
Utility
Process for Preparing Extracellular Vesicles
16 Nov 23
The present disclosure relates to multistep chromatographic methods for preparing extracellular vesicles (EVs).
Raymond BOURDEAU, Michael F. DOHERTY, Aaron NOYES, Kayla DESANTY
Filed: 23 Sep 21
Utility
Loading of Extracellular Vesicles Through Imparting of Mechanical Shear
28 Sep 23
Methods of loading extracellular vesicles with payload molecules via homogenization are disclosed herein.
Aaron R. NOYES, Michael P. MERCALDI, Kathryn E. GOLDEN, Raymond W. BOURDEAU, Michael F. DOHERTY, Konstantin KONSTANTINOV, Douglas E. WILLIAMS
Filed: 11 Oct 22
Utility
Targeted Delivery of Extracellular Vesicles
31 Aug 23
The present disclosure relates compartmental administration of modified extracellular vesicles, e.g., exosomes.
Ajay VERMA, Wei ZHANG, Ke XU, Shailendra PATEL
Filed: 15 Mar 21
Utility
Sting Agonist Comprising Exosomes for Treating Neuroimmunological Disorders
3 Aug 23
Abstract: Provided herein are compositions comprising EV, e.g., exosome, which comprises STING agonists and methods of using such compositions for the treatment of neuroimmunological disorders.
Ajay VERMA
Filed: 24 Sep 20
Utility
Anti-transferrin Extracellular Vesicles
13 Jul 23
The present disclosure relates extracellular vesicles, e.g., exosomes, comprising an antigen-binding moeity, e.g., a single-domain antigen-binding moeity, e.g., a vNAR, a VHH, or a fragment thereof, that specifically binds transferrin receptor, and methods of making and using the same.
Ajay VERMA, Leonid GAYDUKOV, Ke XU, Kevin P. DOOLEY, Jonathan FINN
Filed: 7 Jun 21
Utility
Extracellular VESICLE-NLRP3 Antagonist
27 Apr 23
The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an NLRP3 antagonist.
Joanne LIM, Katherine KIRWIN, Wendy BROOM, Sriram SATHYANARAYANAN, Ajay VERMA
Filed: 14 Aug 20
Utility
Extracellular Vesicles for Treating Neurological Disorders
13 Apr 23
The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject.
Ajay VERMA, Tim SOOS, Nikki ROSS, Christine MCCOY, Jonathan FINN, Sriram SATHYANARAYANAN, Shailendra PATEL, Ke XU, Russell E. MCCONNELL, Kevin P. DOOLEY
Filed: 15 Mar 21
Utility
Methods of Producing Extracellular Vesicles
6 Apr 23
Provided herein are methods of preparing EVs, e.g., exosomes, associated with or encapsulated various cyclic dinucleotides, including STING agonists.
Raymond BOURDEAU, Su Chul JANG, Rane HARRISON, Conlin O'NEIL, Aaron NOYES
Filed: 25 Sep 20
Utility
Extracellular Vesicles with Antisense Oligonucleotides Targeting Kras
19 Jan 23
The present disclosure relates to modified extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), which is capable of reducing and/or inhibiting expression of KRAS mRNA and/or KRAS protein.
Dalia BURZYN, Sushrut KAMERKAR, Adam T. BOUTIN, Wendy BROOM, Sriram SATHYANARAYANAN, Monique KAUKE, Stephanie YU, Michael BOCKER
Filed: 14 Aug 20
Utility
Extracellular Vesicle-aso Constructs Targeting Cebp/beta
5 Jan 23
The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a CEBP/transcript.
Dalia BURZYN, Sushrut KAMERKAR, Adam T. BOUTIN, Wendy BROOM, Sriram SATHYANARAYANAN, Ajay VERMA
Filed: 14 Aug 20
Utility
Sting Agonist Comprising Exosomes Combined with IL-12 Displaying Exosomes for Treating a Tumour
15 Dec 22
Provided herein are methods of treating a tumor comprising administering (i) a composition comprising an extracellular vesicle and a STING agonist, e.g., exosome encapsulating STING agonists, in combination with (ii) an IL-12 moiety.
Nuruddeen LEWIS, Sriram SATHYANARAYANAN
Filed: 24 Sep 20
Utility
Process for Preparing Extracellular Vesicles
8 Dec 22
The present disclosure relates to multistep chromatographic methods for preparing extracellular vesicles (EVs).
Aaron NOYES, Michael DOHERTY, Kimberly ELLIS, Raymond BOURDEAU, Kayla DESANTY
Filed: 20 Mar 20
Utility
High-throughput Chromatography Screening for Extracellular Vesicles
8 Dec 22
The present disclosure relates to high-throughput screening methods for identifying one or more chromatography operational parameters (e.g., binding parameters) and/or reagents for purifying EVs (e.g., exosomes) from a sample using chromatography.
Michael DOHERTY, Aaron NOYES, Andrew WOOD
Filed: 5 Nov 20
Utility
Methods and compositions for macrophage polarization
29 Nov 22
Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages.
Sriram Sathyanarayanan, Douglas E. Williams, Dalia Burzyn, Adam Thomas Boutin, Sushrut Kamerkar
Filed: 12 Feb 19
Utility
Extracellular Vesicle Linked to Molecules and Uses Thereof
10 Nov 22
The present disclosure relates to extracellular vesicles (e.g., exosomes) comprising a biologically active molecule covalently linked to the extracellular vesicle via an anchoring moiety, which may be useful as an agent for the prophylaxis or treatment of cancer or other diseases.
Yi Zhang, Aaron R. Noyes, Adam T. Boutin
Filed: 14 Aug 20
Utility
Compositions of Exosomes and Aav
13 Oct 22
The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an AAV and a scaffold protein.
Aaron NOYES, Russell E. MCCONNELL, Ke XU, Jonathan FINN
Filed: 17 Apr 20
Utility
Methods of Measuring Exosomes Using Intrinsic Fluorescence
13 Oct 22
Described herein are novel rapid and reliable methods of detection of extracellular vesicles and quantifying extracellular vesicle concentrations and absolute number from various sources, including raw cell harvest.
Damian J. HOUDE, Young Jun CHOI, John D. KULMAN, Douglas E. WILLIAMS
Filed: 28 Mar 22
Utility
Membrane Protein Scaffolds for Exosome Engineering
11 Aug 22
The present disclosure relates to heterologous exosomal vesicle proteins (HEVPs), engineered exosomes comprising HEVPs, and methods of preparing and using these compositions, including therapeutic applications.
Kevin P. DOOLEY, Douglas E. WILLIAMS, James E. THORNTON
Filed: 4 Feb 20