212 patents
Page 8 of 11
Utility
Messenger Rna Therapy for the Treatment of Friedreich's Ataxia
24 Jun 21
The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.
Michael Heartlein, Frank DeRosa, Jonathan Cherry, Paula Lewis, Shrirang Karve, Zarna Patel, Darshan Parekh, Susan Wood, Chi-Sung Chiu, Caroline J. Woo
Filed: 10 Sep 20
Utility
Process of Preparing Mrna-loaded Lipid Nanoparticles
24 Jun 21
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation.
Shrirang Karve, Frank DeRosa, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel
Filed: 21 Dec 20
Utility
Methods For Purification of Messenger RNA
17 Jun 21
The present invention relates, in part, to methods for large-scale purification of mRNA.
Frank DeRosa, Michael Heartlein, Jonathan Abysalh, Daniel Crawford, Anusha Dias, Shrirang Karve
Filed: 22 Dec 20
Utility
Ice-based lipid nanoparticle formulation for delivery of mRNA
25 May 21
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid.
Frank DeRosa, Michael Heartlein, Shrirang Karve
Filed: 11 Oct 19
Utility
Compositions, Methods and Uses of Messenger Rna
20 May 21
The present invention provides, among other things, methods and compositions for selective degradation of proteins.
Richard Wooster, Anusha Dias, Dustin Cooper, Christian Cobaugh, Frank DeRosa, Tim Efthymiou, Jeffrey S. Dubins
Filed: 21 Oct 20
Utility
Modification of RNA-related enzymes for enhanced production
4 May 21
The present invention provides, among other things, methods and compositions for large-scale production of capped mRNA using SUMO-Guanylyl Transferase fusion protein.
Bettina Strack-Logue, Frank DeRosa, Michael Heartlein
Filed: 19 Oct 18
Utility
Methods For Purification of Messenger RNA
29 Apr 21
The present invention relates, in part, to methods for large-scale purification of mRNA.
Jonathan Abysalh, Daniel Crawford, Frank DeRosa, Shrirang Karve, Anusha Dias, Michael Heartlein
Filed: 14 Oct 20
Utility
Cationic Polymers
22 Apr 21
Frank DeRosa, Michael Heartlein, Shrirang Karve, Zarna Patel
Filed: 1 Feb 19
Utility
Methods for purification of messenger RNA
13 Apr 21
The present invention relates, in part, to methods for large-scale purification of mRNA.
Frank DeRosa, Michael Heartlein, Jonathan Abysalh, Daniel Crawford, Anusha Dias, Shrirang Karve
Filed: 27 Feb 18
Utility
Compositions and Methods for Modulating MECP2 Expression
8 Apr 21
Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of MECP2.
Arthur M. Krieg, Romesh R. Subramanian, James McSwiggen, Jeannie T. Lee
Filed: 18 May 20
Utility
Polyanionic delivery of nucleic acids
30 Mar 21
Michael Heartlein, Frank DeRosa, Shrirang Karve
Filed: 7 Mar 18
Utility
Lipid formulations for delivery of messenger RNA
30 Mar 21
Michael Heartlein, Daniel Anderson, Yizhou Dong, Frank DeRosa
Filed: 15 Nov 19
Utility
Ice-based lipid nanoparticle formulation for delivery of mRNA
9 Mar 21
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid.
Frank DeRosa, Michael Heartlein, Shrirang Karve
Filed: 27 Jan 20
Utility
Lipid Nanoparticle Compositions and Methods for Mrna Delivery
4 Mar 21
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell.
Braydon Charles Guild, Frank DeRosa, Michael Heartlein
Filed: 16 Nov 20
Utility
Compositions and Methods for Facilitating Delivery of Synthetic Nucleic Acids to Cells
25 Feb 21
Provided herein are compositions and methods for facilitating or enhancing delivery of nucleic acids, such as synthetic mRNAs, into cells or tissues.
Balkrishen Bhat, Jia Tay, Saswata Karmakar, Nelson Chau
Filed: 10 Jan 19
Utility
Stable Compositions of Mrna-loaded Lipid Nanoparticles and Processes of Making
18 Feb 21
The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs).
Shrirang Karve, Frank DeRosa, Michael Heartlein, Natalia Vargas Montoya, Priyal Patel, Ashish Sarode
Filed: 23 Jul 20
Utility
Lipid-derived Neutral Nanoparticles
11 Feb 21
Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions.
Frank DeRosa, Braydon Charles Guild, Michael Heartlein
Filed: 26 Aug 20
Utility
Biodegradable lipids for delivery of nucleic acids
9 Feb 21
Frank DeRosa, Michael Heartlein
Filed: 22 Nov 19
Utility
Methods and compositions for delivering MRNA coded antibodies
26 Jan 21
The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject.
Michael Heartlein, Frank DeRosa, Anusha Dias, Braydon Charles Guild
Filed: 24 Jan 20
Utility
Ionizable Cationic Lipids
14 Jan 21
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use.
Frank DeRosa, Braydon Charles Guild, Michael Heartlein
Filed: 3 Aug 20