140 patents
Page 6 of 7
Utility
CNS Delivery of Mrna and Uses Thereof
1 Jul 21
The present invention provides, among other things, methods and compositions for effective delivery of messenger RNA (mRNA) to the central nervous system (CNS).
Frank DeRosa, Michael Heartlein, Shrirang Karve
Filed: 25 Aug 20
Utility
Messenger Rna Therapy for Treatment of Articular Disease
1 Jul 21
The present invention provides, among other things, a method of intra-articular delivery of messenger RNA (mRNA), comprising administering into a joint of a subject in need of delivery a composition comprising an mRNA encoding a protein, such that the administering of the composition results in expression of the protein encoded by the mRNA in the joint.
Frank DeRosa, Michael Heartlein
Filed: 10 Dec 20
Utility
Process of Preparing Mrna-loaded Lipid Nanoparticles
24 Jun 21
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation.
Shrirang Karve, Frank DeRosa, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel
Filed: 21 Dec 20
Utility
Messenger Rna Therapy for the Treatment of Friedreich's Ataxia
24 Jun 21
The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.
Michael Heartlein, Frank DeRosa, Jonathan Cherry, Paula Lewis, Shrirang Karve, Zarna Patel, Darshan Parekh, Susan Wood, Chi-Sung Chiu, Caroline J. Woo
Filed: 10 Sep 20
Utility
Methods For Purification of Messenger RNA
17 Jun 21
The present invention relates, in part, to methods for large-scale purification of mRNA.
Frank DeRosa, Michael Heartlein, Jonathan Abysalh, Daniel Crawford, Anusha Dias, Shrirang Karve
Filed: 22 Dec 20
Utility
Compositions, Methods and Uses of Messenger Rna
20 May 21
The present invention provides, among other things, methods and compositions for selective degradation of proteins.
Richard Wooster, Anusha Dias, Dustin Cooper, Christian Cobaugh, Frank DeRosa, Tim Efthymiou, Jeffrey S. Dubins
Filed: 21 Oct 20
Utility
Methods For Purification of Messenger RNA
29 Apr 21
The present invention relates, in part, to methods for large-scale purification of mRNA.
Jonathan Abysalh, Daniel Crawford, Frank DeRosa, Shrirang Karve, Anusha Dias, Michael Heartlein
Filed: 14 Oct 20
Utility
Cationic Polymers
22 Apr 21
Frank DeRosa, Michael Heartlein, Shrirang Karve, Zarna Patel
Filed: 1 Feb 19
Utility
Compositions and Methods for Modulating MECP2 Expression
8 Apr 21
Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of MECP2.
Arthur M. Krieg, Romesh R. Subramanian, James McSwiggen, Jeannie T. Lee
Filed: 18 May 20
Utility
Lipid Nanoparticle Compositions and Methods for Mrna Delivery
4 Mar 21
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell.
Braydon Charles Guild, Frank DeRosa, Michael Heartlein
Filed: 16 Nov 20
Utility
Compositions and Methods for Facilitating Delivery of Synthetic Nucleic Acids to Cells
25 Feb 21
Provided herein are compositions and methods for facilitating or enhancing delivery of nucleic acids, such as synthetic mRNAs, into cells or tissues.
Balkrishen Bhat, Jia Tay, Saswata Karmakar, Nelson Chau
Filed: 10 Jan 19
Utility
Stable Compositions of Mrna-loaded Lipid Nanoparticles and Processes of Making
18 Feb 21
The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs).
Shrirang Karve, Frank DeRosa, Michael Heartlein, Natalia Vargas Montoya, Priyal Patel, Ashish Sarode
Filed: 23 Jul 20
Utility
Lipid-derived Neutral Nanoparticles
11 Feb 21
Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions.
Frank DeRosa, Braydon Charles Guild, Michael Heartlein
Filed: 26 Aug 20
Utility
Ionizable Cationic Lipids
14 Jan 21
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use.
Frank DeRosa, Braydon Charles Guild, Michael Heartlein
Filed: 3 Aug 20
Utility
Ribonucleic Acids with 4'-THIO-MODIFIED Nucleotides and Related Methods
14 Jan 21
Disclosed are messenger RNA molecules and related compositions incorporating a 4′-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mRNAs to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders.
Frank DeRosa, Michael Heartlein
Filed: 25 Sep 20
Utility
Methods for Purification of Messenger Rna
6 Jan 21
The present invention provides, among other things, methods for purifying high quality messenger RNA (mRNA) suitable for clinical use, without using any caustic or flammable solvents.
Jonathan Abysalh, Frank DeRosa, Jorel Vargas, Cameron M. Smith
Filed: 14 May 20
Utility
Synergistic Enhancement of the Delivery of Nucleic Acids via Blended Formulations
16 Dec 20
Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs.
Frank DeRosa, Lianne Smith, Michael Heartlein, Braydon Charles Guild
Filed: 30 Mar 20
Utility
Lipid Nanoparticle Compositions and Methods for Mrna Delivery
28 Oct 20
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell.
Braydon Charles Guild, Frank DeRosa, Michael Heartlein
Filed: 15 Jul 20
Utility
Quantitative Assessment for Cap Efficiency of Messenger Rna
7 Oct 20
The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly mRNA synthesized in vitro.
Michael Heartlein, Frank DeRosa, Anusha Dias
Filed: 15 Jan 20
Utility
Poly(phosphoesters) for Delivery of Nucleic Acids
2 Sep 20
Frank DeRosa, Michael Heartlein, Shrirang Karve, Yi Zhang
Filed: 10 Jun 18