25 patents
Utility
Methods of Tissue Generation
20 May 21
Provided herein are methods for forming three-dimensional tissues in vivo.
Robert J. HARIRI, Mohit B. BHATIA, Wolfgang HOFGARTNER, Jia-Lun WANG, Qian YE
Filed: 23 Jun 20
Utility
Tumor Suppression Using Human Placenta-derived Intermediate Natural Killer Cells and Immunomodulatory Compounds
29 Apr 21
Provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising contacting the tumor cells, or administering to the individual, placental perfusate, placental perfusate cells, or natural killer cells, e.g., placenta-derived intermediate natural killer cells, with an immunomodulatory compound or thalidomide.
Xiaokui ZHANG, LIn KANG, Mohammad A. HEIDARAN, Stephen JASKO, Andrew ZEITLIN, Ajai PAL, Robert J. HARIRI
Filed: 2 Jun 20
Utility
Post Partum Tissue-derived Induced Pluripotent Stem Cells and Uses Thereof
1 Apr 21
The present invention provides an induced pluripotent stem (iPS) cell, or population of iPS cells, wherein the cell or cells giving rise to the iPS cell(s) are obtained from human postpartum tissue or cells, wherein the iPS cell(s) have increased levels of one or more factors selected from Group I: an Oct family member, a Sox family member, a Klf family member, a Myc family member, Nanog, Lin28, and combinations thereof.
James EDINGER, Robert J. HARIRI, Sourav SINHA, Xiaokui ZHANG
Filed: 22 Feb 19
Utility
Method of Producing Erythrocytes
4 Feb 21
Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes.
Mohammad A. Heidaran, Xiaokui Zhang, Lin Kang, Andrew Zeitlin, Vanessa Voskinarian-Berse, Stewart Abbot
Filed: 12 Mar 20
Utility
Extracellular Matrix Composition Beads for Cell Culture
6 Jan 21
Provided herein are methods of culturing cells using microcarriers that include extracellular matrix (ECM).
Robert J. HARIRI, Mohit BHATIA
Filed: 17 Sep 20
Utility
Treatment of Inflammatory Diseases Using Placental Stem Cells
23 Dec 20
Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Herbert Faleck
Filed: 23 Jan 20
Utility
Cell Potency Assay
18 Nov 20
The present disclosure related to methods for assessing potency of cells in a preparation of cells.
Gregory Russotti, Jaymes Fuller, Christopher Wiwi
Filed: 10 Dec 19
Utility
Natural Killer Cells and Uses Thereof
21 Oct 20
Provided herein are methods of producing natural killer (NK) cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors.
Brian MURPHY, Vanessa VOSKINARIAN-BERSE, Andrea NORDBERG, Keith WILSON, Lin KANG
Filed: 17 May 20
Utility
Micro-organoids, and Methods of Making and Using the Same
5 Aug 20
Provided herein are micro-organoids, referred to herein as Functional Physiological Units (FPUs), that are capable of replacing or augmenting one or more physiological functions in an individual, which are useful in the treatment of individuals lacking, or suffering a deficit in, said physiological function.
Robert J. HARIRI, Mohit BHATIA, Jia-Lun WANG, Wolfgang HOFGARTNER, Qian YE
Filed: 20 Apr 20
Utility
Tumor Suppression Using Human Placenta-derived Intermediate Natural Killer (Pink) Cells In Combination with an Antibody
5 Aug 20
Provided herein are methods of suppressing the growth or proliferation of tumor cells and methods of treating individuals having tumor cells using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer (PINK) cells, combined natural killer (NK) cells, or combinations thereof, in combination with an antibody (e.g., anti-disialoganglioside (anti-GD2) antibody).
Xiaokui ZHANG, Lin KANG, Robert J. HARIRI
Filed: 26 Sep 18
Utility
Renovation and Repopulation of Decellularized Tissues and Cadaveric Organs by Stem Cells
17 Jun 20
A method of manufacturing a tissue matrix for implantation into a patient is disclosed.
Robert J. Hariri
Filed: 23 Feb 20
Utility
Methods for Collecting and Using Placenta Cord Blood Stem Cells
6 May 20
An innovative method of collecting cord blood stem cells from an isolated mammalian non-exsanguinated or partially exsanguinated placenta by placental perfusion is described and also an easy method for safe long duration cold storage of the placenta.
Naoko TAKEBE
Filed: 15 Dec 19
Utility
Composition for collecting and preserving placental stem cells and methods of using the composition
16 Mar 20
The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta.
James W. Edinger, Mohammad Heidaran, Wolfgang Hofgartner
Filed: 27 Jul 17
Utility
Methods for quantifying particulates in cell culture
17 Feb 20
Provided are methods for quantifying and/or detecting sub-visible particulates in cell cultures.
Lauren M. Depalma, Daniel Dewitt, Li Ren
Filed: 10 Sep 15
Utility
CD34+,CD45- Placental Stem Cell-enriched Cell Populations
12 Feb 20
Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells.
James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Marian Pereira, Sascha Dawn Abramson, Kristen S. Labazzo
Filed: 17 Oct 19
Utility
Methods for collecting and using placenta cord blood stem cells
3 Feb 20
An innovative method of collecting cord blood stem cells from an isolated mammalian non-exsanguinated or partially exsanguinated placenta by placental perfusion is described and also an easy method for safe long duration cold storage of the placenta.
Naoko Takebe
Filed: 10 Mar 16
Utility
Treatment of Pain Using Placental Stem Cells
22 Jan 20
Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent placental stem cells (PDAC™).
Uri Herzberg, Jodi P. Gurney
Filed: 4 Aug 19
Utility
Cytotherapeutics, Cytotherapeutic Units and Methods for Treatments Using Them
8 Jan 20
The present invention provides cytotherapeutic units comprising predetermined numbers of selected types of potent cells.
Robert J. Hariri
Filed: 4 Aug 19
Utility
Use of Placental Stem Cells In Treatment of Acute Kidney Injury
25 Dec 19
Provided herein are methods of using human placental stem cells in the treatment of subjects having acute kidney injury (AKI).
Steven A. Fischkoff, Hong-Jung Chen
Filed: 13 Aug 19
Utility
Composition for Collecting and Preserving Placental Stem Cells and Methods of Using the Composition
11 Dec 19
The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta.
James W. Edinger, Mohammad Heidaran, Wolfgang Hofgartner
Filed: 21 Aug 19