13 patents
Utility
Solid forms of a CD73 inhibitor and the use thereof
21 Nov 23
Solid forms of Compound I, which modulates the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compound and methods for preparing the solid forms, are described herein.
Jenna Leigh Jeffrey, Kenneth V. Lawson, Dillon Harding Miles
Filed: 12 Dec 19
Utility
Antibodies to TIGIT
21 Nov 23
The present disclosure provides antibodies that specifically bind to TIGIT.
Kelsey Sivick Gauthier, Nigel Pelham Clinton Walker, Xiaoning Zhao, John Lippincott
Filed: 1 Jun 21
Utility
Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha
17 Oct 23
Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein.
Joel Worley Beatty, Samuel Lawrie Drew, Matthew Epplin, Jeremy Thomas Andre Fournier, Balint Gal, Tezcan Guney, Karl T. Haelsig, Clayton Hardman, Steven Donald Jacob, Jenna Leigh Jeffrey, Jaroslaw Kalisiak, Kenneth Victor Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Artur Karenovich Mailyan, Debashis Mandal, Guillaume Mata, Hyunyoung Moon, Jay Patrick Powers, Brandon Reid Rosen, Yongli Su, Anh Thu Tran, Zhang Wang, Xuelei Yan, Kai Yu
Filed: 8 Jun 22
Utility
Crystalline forms of a CD73 inhibitor and uses thereof
16 May 23
Crystalline forms of the compound of Formula (I), which modulates the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compound and methods for preparing the crystalline forms, are described herein.
Andrew M. K. Pennell, Eric F. Connor, Stephen Edmund Gottschling, Jim Dimetrios Colomvakos, Mohammed Asadullah Khan
Filed: 16 Jun 21
Utility
Oral formulations of CD73 compounds
25 Apr 23
Kenneth Victor Lawson, Manmohan Reddy Leleti, Jay Patrick Powers
Filed: 5 Mar 21
Utility
Dosing with an azolopyrimidine compound
25 Oct 22
Joyson Karakunnel
Filed: 14 Feb 19
Utility
Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2α
9 Aug 22
Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein.
Joel Worley Beatty, Samuel Lawrie Drew, Matthew Epplin, Jeremy Thomas Andre Fournier, Balint Gal, Tezcan Guney, Karl T. Haelsig, Clayton Hardman, Steven Donald Jacob, Jenna Leigh Jeffrey, Jaroslaw Kalisiak, Kenneth Victor Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Artur Karenovich Mailyan, Debashis Mandal, Guillaume Mata, Hyunyoung Moon, Jay Patrick Powers, Brandon Reid Rosen, Yongli Su, Anh Thu Tran, Zhang Wang, Xuelei Yan, Kai Yu
Filed: 18 Mar 21
Utility
Inhibitors of CD73-mediated immunosuppression
8 Mar 22
Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein.
Jaroslaw Kalisiak, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Dillon Harding Miles, Eric Newcomb, Jay Patrick Powers, Ehesan Ul Sharif
Filed: 17 Nov 17
Utility
Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders
11 Jan 22
Manmohan Reddy Leleti, Dillon Harding Miles, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif
Filed: 16 May 18
Utility
Azolopyrimidine for the treatment of cancer-related disorders
27 Jul 21
Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein.
Joel Beatty, Laurent Debien, Jenna Jeffrey, Manmohan Reddy Leleti, Debashis Mandal, Dillon Miles, Jay Powers, Brandon Rosen, Ehesan Sharif, Rhiannon Thomas-Tran
Filed: 2 Jul 19
Utility
Inhibitors of adenosine 5′-nucleotidase
13 Jul 21
Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein.
Laurent Pierre Paul Debien, Jaroslaw Kalisiak, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Dillon Harding Miles, Eric Newcomb, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif
Filed: 2 Oct 17
Utility
Quinazoline-pyridine derivatives for the treatment of cancer-related disorders
29 Jun 21
Manmohan Reddy Leleti, Dillon Harding Miles, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif, Rhiannon Thomas-Tran
Filed: 3 May 18
Utility
Modulators of 5′-nucleotidase, ecto and the use thereof
11 May 21
Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein.
Laurent Pierre Paul Debien, Juan Carlos Jaen, Jaroslaw Kalisiak, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Dillon Harding Miles, Eric Newcomb, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif
Filed: 1 Sep 20
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