61 patents
Page 2 of 4
Utility
Modular Vial Adapter
16 Sep 21
The present disclosure is directed to a vial adapter for interconnecting a vial and a fluid delivery device, and, more particularly, to a vial adapter having a modular design consisting of separately constructed components cooperatively arranged and coupled to one another.
Scott Richard ARIAGNO, Daniel Edward ROUSH
Filed: 3 Jun 21
Utility
Small Unit Dosage Plunger Rod Stops
9 Sep 21
Plunger rod stops attach to existing syringes to limit the range of motion of the plunger, thereby to precisely control the amount of liquid that can be expelled from the syringe when the plunger rod stop is in place.
Steve BOWMAN, Chase FETZER, Richard BRAGA, Evi SHIAKOLAS
Filed: 13 May 21
Utility
ANTI-FLT-1 Antibodies In Treating Bronchopulmonary Dysplasia
26 Aug 21
The present invention provides, among other things, methods and compositions for treating chronic lung disorders, in particular, bronchopulmonary dysplasia (BPD).
Dennis Keefe, Jennifer Bosco, Steven Abman
Filed: 21 Jun 19
Utility
Methods and compositions for CNS delivery of heparan n-sulfatase
20 Jul 21
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases.
Farah Natoli, Gaozhong Zhu, Jennifer Terew, Yuan Jiang, Jamie Tsung, Zahra Shahrokh, Brian Vernaglia, Jing Pan, Richard Pfeifer, Pericles Calias
Filed: 16 Jul 18
Utility
Therapeutic fusion protein comprising an alpha-n-acetylglucosaminidase and a lysosomal targeting moiety
20 Jul 21
Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein.
Michael F. Concino, Pericles Calias, Jing Pan, Kevin Holmes, Paolo Martini, Alla Romashko, Muthuraman Meiyappan, Bohong Zhang, Andrea Iskenderian, Dianna Lundberg, Angela Norton, Bettina Strack-Logue, Huang Yan, Mary Alessandrini, Richard Pfeifer
Filed: 26 Sep 17
Utility
Anti-CCL2 and anti-LOXL2 combination therapy for treatment of scleroderma
13 Jul 21
The present invention provides, among other things, bi-specific molecules including, but not limited to, antibodies, fynomers, aptamers, fusion proteins, and protein binding domains that bind both CCL2 and LOXL2 and uses thereof, in particular, for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions.
Paolo G. V. Martini, Madhusudan Natarajan, Patrick Anthony John Haslett, Albert Barnes Seymour
Filed: 23 May 14
Utility
ANTI-FLT-1 Antibodies for Treating Duchenne Muscular Dystrophy
8 Jul 21
The present invention provides, among other things, anti-Flt-I antibodies and methods for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD).
Dennis KEEFE, Hans DE HAARD, Natalie DE JONGE, Sofie GABRIELS
Filed: 12 Aug 20
Utility
Modular vial adapter
15 Jun 21
The present disclosure is directed to a vial adapter for interconnecting a vial and a fluid delivery device, and, more particularly, to a vial adapter having a modular design consisting of separately constructed components cooperatively arranged and coupled to one another.
Scott Richard Ariagno, Daniel Edward Roush
Filed: 13 Dec 17
Utility
ANTI-FLT-1 Antibodies In Treating Duchenne Muscular Dystrophy
3 Jun 21
The present invention provides, among other things, methods and compositions for treating muscular dystrophy, in particular.
Serene Josiah, Thomas M. Luby, Atsushi Asakura, Dennis Keefe, Lawrence Charnas, Mayank Verma
Filed: 14 Jul 20
Utility
Methods and compositions for CNS delivery of arylsulfatase A
1 Jun 21
Provided are methods of treating metachromatic leukodystrophy comprising administering to a subject in need of treatment a therapeutically effective amount of recombinant arylsulfatase A enzyme.
Margaret Wasilewski, Anna Wijatyk
Filed: 17 Feb 17
Utility
Small unit dosage plunger rod stops
25 May 21
Plunger rod stops attach to existing syringes to limit the range of motion of the plunger, thereby to precisely control the amount of liquid that can be expelled from the syringe when the plunger rod stop is in place.
Steve Bowman, Chase Fetzer, Richard Braga, Evi Shiakolas
Filed: 6 Nov 17
Utility
ANTI-FLT-1 Antibodies In Treating Bronchopulmonary Dysplasia
6 May 21
The present invention provides, among other things, methods and compositions for treating chronic lung disorders, in particular, bronchopulmonary dysplasia (BPD).
Dennis KEEFE, Hans DE HAARD
Filed: 5 Jun 20
Utility
Glucocerebrosidase gene therapy for Parkinson's disease
6 Apr 21
The present invention is directed, in part, to the treatment of a subject having a neurodegenerative disorder, such as Parkinson's disease (PD), by providing glucocerebrosidase enzyme.
Yung Hee Park, Ole Isacson
Filed: 6 May 16
Utility
Drug Monitoring Tool
1 Apr 21
A drug monitoring tool comprises a data receiver and an interactive user interface.
Gerald SPOTTS, Roman PICHLER, Michael NELSON
Filed: 11 Dec 20
Utility
Plasma Kallikrein Inhibitors and Uses Thereof
18 Mar 21
The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
Nikolaos Papaioannou, Jeremy Mark Travins, Sarah Jocelyn Fink, John Mark Ellard, Alastair Rae
Filed: 17 Sep 20
Utility
Heteroaryl Plasma Kallikrein Inhibitors
18 Mar 21
The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
Nikolaos Papaioannou, Jeremy Mark Travins, Sarah Jocelyn Fink, John Mark Ellard, Alastair Rae
Filed: 17 Sep 20
Utility
Affinity Purification of Glycoside-cleaving Enzymes
11 Feb 21
The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., α-galactosidase A (α-Gal A), glucocerebrosidase (GCB), β-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.
Brian Dwyer, Bohong Zhang, Jun Hu, Muthuraman Meiyappan, Thomas Miller, Paul McLean, Clark Pan
Filed: 5 Mar 19
Utility
Drug monitoring tool
19 Jan 21
Embodiments of the present disclosure relate to a drug monitoring tool.
Gerald Spotts, Roman Pichler, Michael Nelson
Filed: 22 Jan 18
Utility
Methods and Compositions for CNS Delivery of Arylsulfatase A
30 Dec 20
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases.
Nazila Salamat-Miller, Katherine Taylor, Paul Campolieto, Zahra Shahrokh, Jing Pan, Lawrence Charnas, Teresa Leah Wright, Pericles Calias
Filed: 23 Mar 20
Utility
Purified Arylsulfatase a and Compositons Thereof
9 Dec 20
The present invention provides, among other things, methods of treatment of Metachromatic Leukodystrophy Disease (MLD) and compositions comprising recombinant arylsulfatase A (ASA) protein using enzyme replacement therapy.
Andrew Keefe, George Enriquez
Filed: 18 Dec 18