71 patents
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VACCINATION WITH mRNA-CODED ANTIGENS
28 Jan 21
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in an elderly patient preferably exhibiting an age of at least 50 years, more preferably of at least 55 years, 60 years, 65 years, 70 years, or older, wherein the treatment comprises vaccination of the patient and eliciting an immune response in said patient.
Karl-Josef KALLEN, Thomas KRAMPS, Margit SCHNEE, Benjamin PETSCH, Lothar STITZ
Filed: 9 Oct 20
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Optimized Nucleic Acid Molecules
23 Dec 20
The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules.
Patrick BAUMHOF, Susanne RAUCH, Aleksandra KOWALCZYK, Johannes LUTZ, Edith JASNY, Benjamin PETSCH, Andreas THESS, Thomas SCHLAKE, Mariola FOTIN-MLECZEK, Regina HEIDENREICH, Sandra LAZZARO, Fatma FUNKNER, Wolfgang GROSSE
Filed: 8 Sep 20
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Linear Double Stranded Dna Coupled to a Single Support or a Tag and Methods for Producing Said Linear Double Stranded Dna
16 Dec 20
The present invention is concerned with linear double stranded DNA, which is coupled to a single support or a tag at the 3′ end of its non-coding strand and methods for producing said linear double stranded DNA.
Benyamin YAZDAN PANAH, Tilmann ROOS, Veronika WAGNER, Carola PONGRATZ
Filed: 20 Dec 18
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Dry Powder Composition Comprising Long-chain Rna
9 Dec 20
The present invention is directed to a storage-stable formulation of long-chain RNA.
Fabian Johannes EBER, Benyamin YAZDAN PANAH, Stefanie SEWING, Thomas KETTERER, Thorsten MUTZKE, Tilmann ROOS, Michael SONNTAG, Michael WIGGENHORN, Katharina KOLLAND
Filed: 19 Aug 20
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Nucleic Acid Comprising or Coding for a Histone Stem-loop and a Poly(a) Sequence or a Polyadenylation Signal for Increasing the Expression of an Encoded Pathogenic Antigen
4 Nov 20
The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal.
Andreas THESS, Thomas SCHLAKE, Jochen PROBST
Filed: 23 Jul 20
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Disulfide-linked Polyethyleneglycol/peptide Conjugates for the Transfection of Nucleic Acids
28 Oct 20
The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex.
Patrick BAUMHOF, Thomas SCHLAKE
Filed: 14 Jul 20
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Artificial Nucleic Acid Molecules for Improved Protein or Peptide Expression
21 Oct 20
The invention relates to an artificial nucleic acid molecule comprising at least one 5′UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop.
Andreas THESS
Filed: 3 Jul 20
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Vaccination In Newborns and Infants
7 Oct 20
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of the newborn or infant and eliciting an immune response in said newborn or infant.
Karl-Josef KALLEN, Thomas KRAMPS, Margit SCHNEE, Benjamin PETSCH, Lothar STITZ
Filed: 23 Jun 20
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Method for Purifying Rna
7 Oct 20
The present invention relates to methods for purifying RNA by chromatography under high salt conditions, e.g. by hydrophobic interaction chromatography.
Andreas FUNKNER, Stefanie SEWING, Isabel STROBEL, Thorsten MUTZKE
Filed: 27 Nov 17
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Nucleic Acid Comprising or Coding for a Histone Stem-loop and a Poly(a) Sequence or a Polyadenylation Signal for Increasing the Expression of an Encoded Protein
2 Sep 20
The present application describes a coding nucleic acid sequence, particularly a messenger RNA (mRNA), comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal and the use thereof for increasing the expression of an encoded protein.
Andreas THESS, Thomas SCHLAKE, Jochen PROBST
Filed: 14 Apr 20
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Rabies Vaccine
26 Aug 20
Margit SCHNEE, Thomas KRAMPS, Lothar STITZ, Benjamin PETSCH
Filed: 30 Apr 20