18 patents
Utility
Methods for Stimulating Proliferation or Differentiation of an Immune Cell with a Multi-chain Chimeric Polypeptide
14 Dec 23
The present disclosure relates to the field of biotechnology, and more specifically, to single-chain and multi-chain chimeric polypeptides having a linker domain positioned between two target-binding domains that are useful for a variety of applications including, without limitation, stimulating an immune cell, inducing or increasing proliferation of an immune cell, inducing differentiation of an immune cell, or treating a subject in need thereof (e.g., a subject having cancer or an aging-related disease or condition).
Hing Wong
Filed: 30 Jun 23
Utility
Multi-chain Chimeric Polypeptides and Uses Thereof
30 Nov 23
The present disclosure relates to methods that include the use of a first multi-chain chimeric polypeptide and a second multi-chain chimeric polypeptide for stimulating the NK cells, inducing or increasing proliferation of the NK cells, inducing differentiation of the NK cells, and treating a subject in need thereof using activated NK cells.
Hing C. Wong
Filed: 19 Jul 23
Utility
Methods of Treating Aging-related Disorders
23 Nov 23
Provided herein are methods of treating an aging-related disease or condition in a subject in need thereof, killing or reducing the number of senescent cells in a subject in need thereof, improving the texture and/or appearance of skin and/or hair in a subject in need thereof, and assisting in the treatment of obesity in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more natural killer (NK) cell activating agent(s) and/or a therapeutically effective number of activated NK cells.
Hing Wong
Filed: 28 Apr 23
Utility
Methods of Reducing Neuroinflammation
23 Nov 23
Provided herein are multi-chain chimeric polypeptides and use thereof in reducing neuroinflammation in a subject.
Hing C. Wong, Varghese George, Niraj Shrestha, Pallavi Chaturvedi
Filed: 13 Apr 23
Utility
Multi-chain Chimeric Polypeptides and Uses Thereof
31 Aug 23
Hing Wong
Filed: 19 Oct 22
Utility
Multi-chain Chimeric Polypeptides and Uses Thereof
27 Apr 23
Hing Wong
Filed: 19 Oct 22
Utility
Multi-chain Chimeric Polypeptides and Use Thereof In the Treatment of Liver Diseases
27 Apr 23
Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases.
Hing C. Wong, Xiaoyun Zhu, Pallavi Chaturvedi, Varghese George, Niraj Shrestha, Michael Dee
Filed: 11 Aug 22
Utility
Single-chain Chimeric Polypeptides and Uses Thereof
9 Feb 23
Provided herein are single-chain chimeric polypeptides that include: (i) a first target-binding domain; (ii) a soluble tissue factor domain; and (iii) a second target-binding domain.
Hing Wong
Filed: 21 Jul 22
Utility
Single-chain Chimeric Polypeptides and Uses Thereof
26 Jan 23
Provided herein are single-chain chimeric polypeptides that include: (i) a first target-binding domain; (ii) a soluble tissue factor domain; and (iii) a second target-binding domain.
Hing Wong
Filed: 22 Jul 22
Utility
Methods of Treating Aging-related Disorders
10 Mar 22
Provided herein are methods of killing or reducing the number of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, decreasing the accumulation of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more common gamma-chain family cytokine receptor activating agent(s) and/or one or more agent(s) that result(s) in a decrease in the activation of a TGF-β receptor.
Hing C. Wong, Xiaoyun Zhu, Bai Liu, Pallavi Chaturvedi, Varghese George
Filed: 1 Jun 21
Utility
Methods of Treating Age-related and Inflammatory Diseases
4 Nov 21
Provided herein are methods of treating an aging-related disease or inflammatory disease in a subject that include (i) a therapeutically effective amount of an NK cell activating agent and/or an NK cell and/or monoclonal antibody; and (ii) a therapeutically effective amount of a Treg cell activating agent and/or a Treg cell and/or a monoclonal antibody and/or AGE inhibitor.
Hing C. Wong
Filed: 11 Feb 21
Utility
Chromatography Resin and Uses Thereof
9 Sep 21
An affinity chromatography resin comprising an anti-tissue factor antibody or antigen-binding fragment thereof attached to a base resin, and methods of using the same.
Hing C. Wong, Jin-an Jiao, Caitlin Prendes
Filed: 11 Feb 21
Utility
Methods of Activating Regulatory T Cells
2 Sep 21
Provided herein are methods of stimulating or increasing the proliferation of a Treg cell, compositions including a population of Treg cells generated by these methods, and methods of treating a subject using these compositions.
Hing C. Wong, Niraj Shresha, Varghese George, Michael Dee
Filed: 11 Feb 21
Utility
Multi-chain Chimeric Polypeptides and Uses Thereof
13 May 21
The present disclosure relates to methods that include the use of a first multi-chain chimeric polypeptide and a second multi-chain chimeric polypeptide for stimulating the NK cells, inducing or increasing proliferation of the NK cells, inducing differentiation of the NK cells, and treating a subject in need thereof using activated NK cells.
Hing C. Wong
Filed: 19 Jun 20
Utility
Single-chain and Multi-chain Chimeric Polypeptides and Uses Thereof
8 Apr 21
The present disclosure relates to the field of biotechnology, and more specifically, to single-chain and multi-chain chimeric polypeptides having a linker domain positioned between two target-binding domains that are useful for a variety of applications including, without limitation, stimulating an immune cell, inducing or increasing proliferation of an immune cell, inducing differentiation of an immune cell, or treating a subject in need thereof (e.g., a subject having cancer or an aging-related disease or condition).
Hing Wong
Filed: 30 Aug 19
Utility
Multi-chain Chimeric Polypeptides and Uses Thereof
11 Mar 21
Hing Wong
Filed: 19 Nov 20
Utility
Multi-chain Chimeric Polypeptides and Uses Thereof
11 Mar 21
Hing Wong
Filed: 19 Nov 20
Utility
Methods of Treating Aging-related Disorders
4 Mar 21
Provided herein are methods of treating an aging-related disease or condition in a subject in need thereof, killing or reducing the number of senescent cells in a subject in need thereof, improving the texture and/or appearance of skin and/or hair in a subject in need thereof, and assisting in the treatment of obesity in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more natural killer (NK) cell activating agent(s) and/or a therapeutically effective number of activated NK cells.
Hing Wong
Filed: 30 Aug 19
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