8 patents
Utility
Antigen binding molecules that bind light
28 Nov 23
The present invention relates antigen binding molecules, particularly antibodies, fragments and variants thereof, that bind to the TNF-related cytokine LIGHT (TNFSF14), competing with LIGHT binding to cellular receptors Herpes virus entry mediator (HVEM) and lymphotoxin beta receptor, and the use of said antigen binding molecules in treating and/or preventing inflammatory disorders and immune disorders.
Steve Holmes
Filed: 24 Jan 18
Utility
Medium- or Macro-cyclic Benzyl-substituted Heterocycle Derivatives and Their Uses As OREXIN-2 Receptor Agonists
19 Oct 23
Bruce LEFKER, Gordon SAXTY, Karl GIBSON, Mark PICKWORTH, Matthew SPENDIFF, Miles Stuart CONGREVE, Paul HUMPHRIES
Filed: 3 Sep 21
Utility
Anti C-met Antibodies
21 Sep 23
Provided herein are antibody molecules that bind specifically to C-MET and related nucleic acid molecules, vectors and host cells.
William James Jonathan Finlay
Filed: 21 Apr 23
Utility
Bicyclic-heterocycle Derivatives and Their Uses As OREXIN-2 Receptor Agonists
31 Aug 23
Bruce LEFKER, Karl GIBSON, Matthew SPENDIFF, Paul HUMPHRIES, Sarah BUCKNELL, Wojciech ZAWODNY, Roderick Alan PORTER
Filed: 3 Sep 21
Utility
Stat Inhibitory Compounds and Compositions
25 May 23
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5).
Roman FLECK, John PROUDFOOT, Jeff OMEARA, Krishna Kumar GNANASEKARAN, Patrick Thomas GUNNING, Alford Antoine JOHN, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA, Ahmed Magdy Ahmed Mohamed ALI
Filed: 5 Mar 21
Utility
Heterocycle Containing Stat Inhibitors and Compositions
18 May 23
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5).
Roman FLECK, John PROUDFOOT, Krishna Kumar GNANASEKARAN, Patrick Thomas GUNNING, Alford Antoine JOHN, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA
Filed: 5 Mar 21
Utility
Alpha Substituted Stat Inhibitors and Compositions Thereof
4 May 23
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5).
Roman FLECK, John PROUDFOOT, Jeff OMEARA, Patrick Thomas GUNNING, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA
Filed: 5 Mar 21
Utility
Compounds and Their Use for the Treatment of ALPHA1-ANTITRYPSIN Deficiency
27 Apr 23
The invention relates to specified benzamide compounds of formula (1), and pharmaceutical compositions containing the compounds.
Nigel RAMSDEN, David John FOX, James Andrew HUNTINGTON, James Michael TOMLINSON
Filed: 13 Jun 22
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