371 patents
Utility
Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
16 Jan 24
Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.
Haiming Zhang, Jie Xu, Georg Wuitschik, Remy Angelaud, Sebastian Herold, Alfred Stutz, Tobias Bruetsch, Johannes Burkhard
Filed: 28 Jun 21
Utility
Cysteine engineered antibodies and conjugates
16 Jan 24
Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.
Sunil Bhakta, Jagath R. Junutula
Filed: 11 Feb 20
Utility
Composition and methods for stabilizing liquid protein formulations
9 Jan 24
The present disclosure provides liquid formulations comprising polypeptides and surfactants.
Anthony Tomlinson, Barthelemy Luc Demeule, Isidro Angelo Eleazar Zarraga
Filed: 26 Jun 20
Utility
Humanized anti-CD79B antibodies and immunoconjugates and methods of use
9 Jan 24
The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
Yvonne Chen, Mark Dennis, Kristi Elkins, Jagath Reddy Junutula, Andrew Polson, Bing Zheng
Filed: 19 Apr 21
Utility
Bispecific antigen-binding molecules and methods of use
9 Jan 24
The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2).
Diego Ellerman, Teemu T. Junttila, Twyla Noelle Lombana, Dionysos Slaga, Christoph Spiess
Filed: 8 Feb 19
Utility
Diagnostic and therapeutic methods for cancer
2 Jan 24
The present invention provides diagnostic and therapeutic methods and compositions for cancer.
Christiaan Nicolaas Klijn, Shiva Malek, Ivana Yen
Filed: 7 Sep 18
Utility
Bioanalytical analysis of site-specific antibody drug conjugates
2 Jan 24
Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.
Martine Darwish, Surinder Kaur, Dian Su, Keyang Xu
Filed: 26 May 20
Utility
Apparatus and methods for low-volume medicament delivery
19 Dec 23
Apparatus and methods for delivering medicament.
Lionel Vedrine, Ariel Waitz
Filed: 15 May 19
Utility
Anti-Ly6G6D antibodies and methods of use
19 Dec 23
Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.
WeiYu Lin, Christoph Spiess, Liping Sun, Yan Wu, Cecilia P. C. Chiu, Walter Christian Darbonne, Michael Andrew Dillon
Filed: 11 Dec 20
Utility
Polysorbate mixtures having modified fatty acid ester distribution
5 Dec 23
The present disclosure provides polysorbate 20 compositions with particular fatty acid ester concentrations.
Sandeep Yadav, Nidhi Doshi, Tamanna Shobha, Anthony Tomlinson, Amit Srivastava
Filed: 23 Sep 21
Utility
Bicyclic ketone compounds and methods of use thereof
5 Dec 23
Snahel Patel, Gregory Hamilton, Guiling Zhao, Huifen Chen, Blake Daniels, Craig Stivala
Filed: 12 Jan 21
Utility
Multiplexed target-binding candidate screening analysis
5 Dec 23
A method and system for normalizing a polymerase chain reaction (PCR) amplification process for a plurality of samples containing DNA.
Christian N. Cunningham, Kenneth Karl Hallenbeck
Filed: 14 Oct 21
Utility
TDO2 and IDO1 inhibitors
28 Nov 23
Presently provided are inhibitors of TD02 and IDO1 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.
Zhonghua Pei, Brendan Parr, Wendy Liu, Richard Pastor, Lewis Gazzard, Firoz Jaipuri, Sanjeev Kumar, Hima Potturi, Guoshen Wu, Xingyu Lin, Yanyan Chu, Powai Yuen
Filed: 28 Jun 18
Utility
Defect detection in lyophilized drug products with convolutional neural networks
7 Nov 23
In one embodiment, a method includes receiving one or more querying images associated with a container of a pharmaceutical product, each of the one or more querying images being based on a particular angle of the container of the pharmaceutical product, calculating one or more confidence scores associated with one or more defect indications, respectively for the container of the pharmaceutical product, by processing the one or more querying images using a target machine-learning model, and determining a defect indication for the container of the pharmaceutical product from the one or more defect indications based on a comparison between the one or more confidence scores and one or more predefined threshold scores, respectively.
Zheng Li, Calvin Tsay
Filed: 7 Jan 22
Utility
Methods of making fucosylated and afucosylated forms of a protein
31 Oct 23
The present application relates to methods of producing a protein in fucosylated and afucosylated forms at a predetermined ratio.
Shahram Misaghi, John B. Lowe, Bradley Richard Snedecor
Filed: 13 Jan 21
Utility
Therapeutic compounds, compositions and methods of use thereof
24 Oct 23
Mark Zak, Terry Kellar, Paul Gibbons
Filed: 21 Sep 20
Utility
Therapeutic compounds and methods of use
17 Oct 23
The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
Jason R. Zbieg, Paul Powell Beroza
Filed: 22 Jul 21
Utility
Combination therapies
10 Oct 23
The present invention relates generally to the fields of molecular biology and growth factor regulation.
Gordon Bray, Iris Chan
Filed: 9 Aug 21
Utility
Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
10 Oct 23
Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
Cheol Keun Chung, Jie Xu, Hans Iding, Kyle Clagg, Michael Dalziel, Alec Fettes, Francis Gosselin, Ngiap-Kie Lim, Andrew McClory, Haiming Zhang, Paroma Chakravarty, Karthik Nagapudi, Sarah Robinson
Filed: 3 Dec 20
Utility
Syringe and method of preparing syringe
3 Oct 23
A syringe (18) has a longitudinal body (28) with an interior (228) in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body (228) and a rigid needle shield (38) encasing the needle.
Frank Bamberg, Heather L. Flores, Robert Müller, Elisabeth Schaible, Edward Schwarb, Lionel Vedrine, Kewei Yang, Mathieu Rigollet, Pierre Goldbach, Baboo Dushyantsingh Goordyal, Ivy Lin, Florian Wildenhahn
Filed: 18 Feb 22