4 patents
Utility
Chlorotoxin agents and uses thereof
28 Nov 23
The present invention provides, among other things, compositions and methods relating to detection and/or treatment cancer (e.g., one or more tumors) that expresses Neuropilin 1 (NRP1).
Sharon McGonigle, Utpal Majumder, Maarten H. D. Postema
Filed: 14 Sep 18
Utility
Chlorotoxin Agents and Uses Thereof
1 Jul 20
The present invention provides, among other things, compositions and methods relating to detection and/or treatment cancer (e.g., one or more tumors) that expresses Neuropilin 1 (NRP1).
Sharon McGonigle, Utpal Majumder, Maarten H. D. Postema
Filed: 13 Sep 18
Utility
Methods for determining prognosis of colorectal cancer
20 Jan 20
Provided herein are methods for determining the risk that a subject diagnosed with colorectal cancer will develop a recurrence of colorectal cancer and methods of predicting clinical outcome for a subject diagnosed with colorectal cancer by a) determining the level of expression for each marker of a panel of markers in a panel of tumor compartments in a tumor tissue sample from the subject, wherein the panel of markers comprises at least two of TEM1, HIF2α, CAIX, PDGFRβ, fibronectin, collagen I, collagen IV, and CD31 and wherein the panel of tumor compartments comprises at least three tumor compartments of pure stroma, tumor, stromal vessel, and tumor vessel; b) determining the TAPPS score for said subject; and c) comparing the TAPPS score of the subject to the TAPPS score of a population of subjects diagnosed with colorectal cancer.
Daniel John O'Shannessy, Nicholas C. Nicolaides, Elizabeth B. Somers
Filed: 21 Jan 18
Utility
Monoclonal antibodies that specifically block biological activity of a tumor antigen
16 Dec 19
This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor.
Luigi Grasso, Nicholas C. Nicolaides, Philip M. Sass
Filed: 8 Mar 17
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