779 patents
Page 2 of 39
Utility
Interferon beta antibodies and uses thereof
2 Jan 24
The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ).
Stefano V. Gulla, Christine Huard, Janet Elizabeth Buhlmann, Juan Carlos Almagro, Sreekumar R. Kodangattil, Steven A. Greenberg, Edward Roland Lavallie, Eric M. Bennett, Lidia Mosyak, James Perry Hall, Anthony John Coyle
Filed: 9 Nov 20
Utility
Talazoparib Soft Gelatin Capsule Dosage Form
28 Dec 23
A pharmaceutical soft gelatin capsule dosage form comprising a soft gelatin shell and a fill, wherein: (a) the soft gelatin shell comprises gelatin and at least one plasticizer; and (b) the fill comprises an anti-oxidant, at least one solvent, and talazoparib or a pharmaceutically acceptable salt thereof.
Alan Francis CARMODY, Lydie Claude Sylvie PAIRET
Filed: 11 Nov 21
Utility
pwtihf0j86d0zuptr9cixyphu4v6mrwj3hrzjm88md1llyzeurps77zh
28 Dec 23
A cell culture medium comprising tyrosine at a concentration of at least 3 mM and polyvinylalcohol (PVA).
Bruno FIGUEROA, Yen-Tung Luan, Wenge Wang
Filed: 31 Aug 23
Utility
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28 Dec 23
In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide.
Kathrin Ute Jansen, Annaliesa Sybil Anderson, Judith Absalon, Jose Miguel Aste-Amezaga, Johannes Frederik Beeslaar, David Cooper, John Erwin Farley, Leah Diane Fletcher, Shannon Lea Harris, Thomas Richard Jones, Isis Kanevsky, Lakshmi Khandke, Paul Liberator, John Lance Perez, Lynn Marie Phelan, Gary Warren Zlotnick
Filed: 29 Jun 23
Utility
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28 Dec 23
The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof.
Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
Filed: 13 Mar 23
Utility
v3o97ljvlfzs3cx0meaypcwi94wqzfbxwjmmk0l
21 Dec 23
Described herein are pharmaceutical compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto.
Neeta Balkrishan Amin, Arthur James Bergman, Roberto Arnaldo Calle, Robert Gregory Dullea, David James Edmonds, William Paul Esler, Kevin James Filipski, James Richard Gosset, Albert Myung Kim, Jeffrey Allen Pfefferkorn, Patrick Robert Verhoest
Filed: 22 Feb 21
Utility
4ean5nte5dbuthxyhgrss90tk3if5dwge8cd79hcs v1
21 Dec 23
The present invention relates to a combination of a) a poxvirus vector encoding at least human papillomavirus (HPV) E6 and E7 polypeptides and an immunostimulatory cytokine, and b) an anti-PD-L1 antibody or antigen-binding fragment thereof, for use in the treatment of an HPV-positive cancer, wherein a first administration of said poxvirus is performed 5 to 10 days before the first administration of said anti-PD-L1 antibody, and subsequent administrations of said poxvirus and anti-PD-L1 antibody are performed.
Kaidre BENDJAMA, Maud BRANDELY-TALBOT, Annette TAVERNARO
Filed: 21 Sep 20
Utility
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21 Dec 23
The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.
Elaine GREER, Stephen ANDERSON, Mark MALONEY, Shu YU, Ekaterina ALBERT, Emily RIGSBEE
Filed: 20 Jan 23
Utility
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21 Dec 23
The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof.
Paul Wayne Brown, Kaushik Dutta, Jason Arnold Lotvin, Kelly Jeffrey Sackett
Filed: 4 Nov 21
Utility
kx910ggca3a5jowotq125xoxcfi1bkt35ix5ald
21 Dec 23
The present disclosure provides antibodies that bind to TNFR2 as well as uses of the antibodies and associated methods.
Todd Douglas ASHWORTH, Yue LIU, Nicholas Andrew MARZE, Virginie MCMANUS
Filed: 25 May 23
Utility
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19 Dec 23
The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.
Elaine Greer, Stephen Anderson, Mark Maloney, Shu Yu, Ekaterina Albert, Emily Rigsbee
Filed: 17 Feb 23
Utility
hn72n2nzwab8a3ew4nfpbyh13zaykofh6thhnyzo rmasijl6plhpwticd
14 Dec 23
A pharmaceutical formulation for parental use comprising testosterone cypionate with a concentration of 200 mg/mL, benzyl benzoate with a concentration of 25%-35% v/v, cottonseed oil, and a preservative.
Christopher Lee Beltz
Filed: 26 Oct 21
Utility
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14 Dec 23
The present disclosure provides methods for purifying a recombinant AAV (rAAV) vector from a solution by anion-exchange chromatography (AEX) to produce an eluate enriched for full capsids and depleted of empty capsids.
Alexander BERRILL, William S. KISH, John R. LIGHTHOLDER, Matthew K. ROACH, William B. WELLBORN, Tamara ZEKOVIC
Filed: 1 Nov 21
Utility
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12 Dec 23
This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
Filed: 11 Nov 22
Utility
zj8sp8ns3hcoceranuw6vnl0
12 Dec 23
The present invention relates to antibodies that specifically bind to B7-H4 (B7 Homology 4, encoded by gene VTCN1) and bispecific antibodies that specifically bind to both B7-H4 and CD3 (Cluster of Differentiation 3), and polynucleotides, pharmaceutical compositions and methods and uses thereof.
James Reasoner Apgar, Andrea Therese Hooper, Malgorzata Agnieszka Nocula-Lugowska, Lei Wu
Filed: 16 Jul 21
Utility
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7 Dec 23
A parenteral aqueous suspension formulation for corticosteroids without polyethylene glycol (PEG) or Polysorbate (PS) that has better resuspendability, longer stability compared to commercially available formulations, and additionally allows for stable formulations of higher concentrations of corticosteroids that were not previously feasible.
Omar Abdelrahman Salman, Joel Aaron Bergman
Filed: 19 Oct 21
Utility
hyzfmcys3ua2jpo1cqwmkeb6vo69pwy
7 Dec 23
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B.
Kathrin Ute Jansen, Annaliesa Sybil Anderson, Robert G.K. Donald, Maninder K. Sidhu, Narender Kumar Kalyan, Justin Keith Moran, Mark Edward Ruppen, Michael James Flint
Filed: 15 Dec 22
Utility
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5 Dec 23
The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
Andrea Therese Hooper, Kimberly Ann Marquette, Chakrapani Subramanyam, Hans-Peter Gerber, Chad Michael May
Filed: 9 Feb 23
Utility
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5 Dec 23
Mark Laurence Boys, Bryan Daniel Ellis, John Joseph Gaudino, Erik James Hicken, Ellen Ruth Laird, Nicholas Charles Lazzara, Bradley Jon Newhouse, Spencer Phillip Pajk
Filed: 29 Jun 21
Utility
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30 Nov 23
Ariamala Gopalsamy, Shawn Cabral, Agustin Casimiro Garcia, Ming Zhu Chen, Chulho Choi, Robert Lee Dow, Olugbeminiyi Omezia Fadeyi, David Hepworth, Jayasankar Jasti, Lyn Howard Jones, Arjun Venkat Narayanan, Mihir Dineshkumar Parikh, David Walter Piotrowski, Lee Richard Roberts, Ralph Pelton Robinson, Jr., Hatice Gizem Yayla
Filed: 24 May 23