23 patents
Utility
Anti-severe Acute Respiratory Syndrome Coronavirus Antibodies
21 Dec 23
Anti-SARS-CoV-specific monoclonal antibodies, methods of making and characterizing those antibodies, and methods of using those antibodies are described herein.
Christine Andrea Goetz, Jody Bonnevier, Christopher David Hammerbeck, Ernesto Rubin Resnik, Cyrus B. Munshi, Enqing Tan
Filed: 24 Nov 21
Utility
Methods and Compositions for Removal of Rna
5 Oct 23
The present disclosure provides compositions and methods related to the removal of RNA from a sample, and the preparation of samples for detection of DNA.
Farzaneh Tondnevis, Li-Chong Wang, Bingqing Zhang, Xiao-Jun Ma
Filed: 17 Sep 21
Utility
Compositions and Methods for Determining T Cell Clonality
21 Sep 23
The present disclosure provides compositions and methods related to the detection of mRNA variants.
Xiao-Jun Ma, Wei Wei, Brenda Nguyen, Niyati Jhaveri, Alisa Baker, Robert Monroe, Bingqing Zhang
Filed: 19 Aug 21
Utility
Methods for Detecting Target Nucleic Acids by In Situ Hybridization and a Kit Thereof
18 May 23
A method of detecting target nucleic acids, including small non-coding RNAs (sncRNAs), microRNAs (miRNAs), small interfering RNAs (siRNAs), PIWI-interacting RNA (piRNA), or antisense oligonucleotides (ASO) molecules, in a cell, comprising a post-fixation step using an aldehyde-containing fixative after the initial fixation step prior to in situ hybridization.
Miguel Angel Mata, Aparna Sahajan, Xiao-Jun Ma, Bingqing Zhang, Li Wang, Li-Chong Wang
Filed: 5 Apr 21
Utility
Methods of Detecting Nucleic Acids In Individual Cells and of Identifying Rare Cells from Large Heterogeneous Cell Populations
18 May 23
Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to nucleic acid are provided.
Yuling Luo, Shiping Chen
Filed: 14 Oct 22
Utility
METHODS OF USING A TGF-beta KNOCKOUT CELL LINE AND COMPOSITIONS RESULTING THEREFROM
11 May 23
This disclosure describes protein compositions including minimal TGFβ1 contamination, methods for making those protein compositions, and methods for using those protein compositions.
Anthony D. Person, John E. Humphrey
Filed: 23 Mar 21
Utility
Apparatus and System for Nucleic Acid Detection
11 May 23
Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided.
Shiping Chen, Yuling Luo
Filed: 14 Oct 22
Utility
Methods for Detecting NTRK Gene Fusion Using Rna In Situ Hybridization
23 Mar 23
A method of detecting a neurotrophic tyrosine receptor kinase (NTRK) fusion gene, comprising obtaining a sample and detecting a NTRK fusion gene in the sample by RNA in situ hybridization using a probe comprising a nucleic acid sequence complementary to a region of mRNA encoding a kinase domain of NTRK1, NTRK2, or NTRK3.
Xiao-Jun Ma, Robert J. Monroe, David T. Ting, Miguel N. Rivera, Vikram Deshpande, Azfar Neyaz, Baris Boyraz
Filed: 24 Feb 21
Utility
Methods for Sequential Detection of Nucleic Acids
5 Jan 23
The invention relates to methods of multiplex detection of a plurality of target nucleic acids by contacting a sample with an acid reagent to remove bound nucleic acid detection systems, thereby allowing the same detection systems to be used again to detect different target nucleic acids and to provide for higher levels of multiplexing.
Li-chong Wang, Han Lu, Bingqing Zhang, Li Wang, Hailing Zong, Xiao-Jun Ma
Filed: 20 Nov 20
Utility
Methods and Compositions for Delivering Compact Lyophilized Agents for Dissolving In a Closed System
3 Nov 22
The invention relates to packaged lyophilized agents.
Timothy John Manning, JR., Joy Lynn Aho, Todd Geders, Sean Henry Kevlahan, Garrett Michael Morris, Charles D. Brawley
Filed: 9 Sep 20
Utility
Detection of Double Stranded Nucleic Acids In Situ and Methods Related Thereto
9 Jun 22
The invention provides methods for detecting target double stranded nucleic acids, including for in situ hybridization assays.
Xiao-Jun MA, Farzaneh TONDNEVIS, Courtney TODOROV, Bingqing ZHANG
Filed: 11 Mar 20
Utility
Surface Plasmon Resonance Sensor Chip Having Sensor Surface Capable of Capturing Multiple Species of Antibodies and Method of Making
2 Jun 22
A surface plasmon resonance chip includes a sensor surface having a substrate, an inert metal layer directly on the substrate, a surface layer directly on the inert metal layer, and fusion proteins immobilized on the surface layer.
Robyn Ann Stoller
Filed: 17 Feb 22
Utility
Methods for Digital Multiplexing of Nucleic Acids In Situ
21 Apr 22
The invention relates to methods of multiplex detection of a plurality of target nucleic acids using combinations of labels by contacting a sample comprising a cell comprising a plurality of target nucleic acids with a set of probes, wherein the set of probes comprises subsets of probes comprising a plurality detectable labels that provide unique labeling of each target nucleic acid, wherein each probe subset comprises one or more distinct labels, wherein the number and/or combination of distinct labels is unique for each target nucleic acid; and detecting the detectable labels bound to the respective target nucleic acids.
Xiao-Jun MA, Emily PARK, Shiping CHEN
Filed: 31 Oct 19
Utility
In Situ Detection of Nucleotide Variants In High Noise Samples, and Compositions and Methods Related Thereto
23 Dec 21
The invention relates to methods of in situ detection of a nucleic acid variation of a target nucleic acid in a sample, including single nucleotide variations, multi-nucleotide variations or splice sites.
Yuling Luo, Xingyong Wu, Liuliu Pan, Xiaoming Wang, Xiao-Jun Ma, Nan Su, Steve Chen
Filed: 29 Jun 21
Utility
WNT/SFRP Complexes, Wnt-containing Compositions, Wnt-expressing Cells, and Methods of Making, Purifying, and Using Same
9 Dec 21
This disclosure describes isolated protein complexes including a Wnt and a sFRP; compositions including a Wnt; a cell overexpressing a Wnt and a sFRP; compositions including a cell overexpressing a Wnt and a cell overexpressing a sFRP; methods of making the protein complexes, compositions, and cells; and methods of using the isolated protein complexes, compositions, and cells.
Anthony Person, Liwen Xiong, Ming Bi, Camrin Tracy
Filed: 18 Jun 21
Utility
Hybridoma Clones, Monoclonal Antibodies to VSIG-4, and Methods of Making and Using
25 Mar 21
Described herein are monoclonal antibodies that bind to VSIG-4 including antibodies that block the binding of VSIG-4 to SIGLEC-7, compositions including the monoclonal antibodies, and methods of making and using those antibodies and compositions.
Birte Aggeler, Christine Goetz, Jody Bonnevier, Christopher Carlin Valley, Christopher Hammerbeck, Ernesto Ruben Resnik
Filed: 19 Aug 20
Utility
Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
4 Feb 21
Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided.
Yuling Luo, Shiping Chen, Huei-Yu Fay Wang, John James Flanagan
Filed: 18 Aug 20
Utility
Methods to Further Enhance Signal Amplification for the In Situ Detection of Nucleic Acids
4 Feb 21
The present invention relates to detection of nucleic acids and provides a composition comprising a Signal Generating Complex, wherein the composition comprises: (A) a pair of target probes (TPs), wherein a first TP of the pair of TPs comprises a nucleic acid sequence comprising two segments; (B) a pair of base PPAs comprising the first and second base PPAs, wherein the first base PPA comprises a nucleic acid sequence comprising three segments; (C) a set of extension PPAs comprising the first and second extension PPAs, wherein the first extension PPA comprises a nucleic acid sequence comprising two segments; (D) a plurality of pre-amplifiers (PAs), wherein the PAs comprise a nucleic acid sequence comprising three segments; (E) a plurality of amplifiers (AMPs), wherein the AMPs comprise a nucleic acid sequence comprising two segments; and (F) a plurality of label probes (LPs), wherein the LPs comprise a nucleic acid sequence comprising two segments.
Yuling LUO, Xiao-Jun MA, Steve CHEN, Nan SU, Emerald DOOLITTLE, Bingqing ZHANG, Xiaoming WANG, Xingyong WU, Xiao Yan PIMENTEL, Helen JARNAGIN
Filed: 8 Apr 19
Utility
Methods of Detecting Nucleic Acids In Individual Cells and of Identifying Rare Cells from Large Heterogeneous Cell Populations
30 Dec 20
Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided.
Yuling Luo, Shiping Chen
Filed: 3 Sep 20
Utility
Methods of Detecting Nucleic Acid Sequences with High Specificity
23 Dec 20
The invention relates to methods of detecting nucleic acids, including methods of detecting one or more target nucleic acid sequences in multiplex branched-chain DNA assays, are provided.
Yuling LUO, John James FLANAGAN, Nan SU, Huei-Yu Fay WANG
Filed: 3 Jun 20