75 patents
Utility
Selective Sulfonation of Benzodiazepine Derivatives
7 Dec 23
The invention relates to novel methods of preparing cell-binding agent-cytotoxic agent conjugates, wherein the cytotoxic agent is an imine-containing cytotoxic agent bearing a maleimide group.
Scott A. Hilderbrand, Benjamin M. Hutchins
Filed: 30 Dec 22
Utility
Methods for Detection of Folate Receptor 1 In a Patient Sample
30 Nov 23
The invention generally relates to methods and kits for the detection of human folate receptor 1 in a sample.
Raymond XU, Kerry CULM-MERDEK
Filed: 6 Mar 23
Utility
Methods for Formulating Antibody Drug Conjugate Compositions
16 Nov 23
The present invention provides improved methods for formulating therapeutic compositions comprising an antibody drug conjugate (“ADC”) that reduce potency variability between batches of ADC and provide for administration of such therapeutic compositions within a narrow intended range.
Gillian PAYNE, Robert W. HERBST, Juma BRIDGEWATER
Filed: 23 Dec 22
Utility
Methods of Treatment Using ANTI-CD123 Immunoconjugates
5 Oct 23
Methods of administering immunoconjugates that bind to CD123 are provided.
Patrick ZWEIDLER-MCKAY, Kerry CULM-MERDEK, Callum SLOSS, Angela ROMANELLI
Filed: 9 Nov 22
Utility
Methods of Preparing Cytotoxic Benzodiazepine Derivatives
14 Sep 23
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Michael Reardon, Richard A. Silva
Filed: 19 Jan 23
Utility
Methods of Preparing Cytotoxic Benzodiazepine Derivatives
17 Aug 23
The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
Filed: 14 Dec 22
Utility
Cytotoxic Benzodiazepine Derivatives
27 Jul 23
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI).
Ravi V.J. Chari, Michael Louis Miller, Manami Shizuka
Filed: 25 Oct 22
Utility
Diagnostic Assays and Kits for Detection of Folate Receptor 1
6 Jul 23
The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1-based therapies.
Christina N. CARRIGAN, Olga AB, Daniel TAVARES, Beni B. WOLF, Nathan E. TESTA
Filed: 2 Jun 22
Utility
Process for Preparing Purified Drug Conjugates
25 May 23
The invention provides a process for preparing a cell-binding agent chemically coupled to a drug.
Yong DAI, Yong WANG, Shengjin JIN, Deborah H. MESHULAM, Godfrey W. AMPHLETT
Filed: 8 Sep 22
Utility
Treatment of Cancer In Patients with Soluble Fr-alpha
13 Apr 23
The present disclosure demonstrates that the amount of soluble folate receptor alpha (FRα) present in a cancer patient is a strong predictor of the efficacy of FRα-targeting therapies.
Eric WESTIN, Jiuzhou WANG, Callum SLOSS
Filed: 2 Jun 22
Utility
Conjugation Methods
6 Apr 23
This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent.
Brenda A. KELLOGG, Rajeeva SINGH, Ravi V. CHARI
Filed: 12 Oct 22
Utility
Cytotoxic Bis-benzodiazepine Derivatives and Conjugates Thereof with Cell-binding Agents for Inhibiting Abnormal Cell Growth or for Treating Proliferative Diseases
30 Mar 23
Ravi V.J. Chari, Michael Louis Miller, Manami Shizuka, Katie Elizabeth Archer, Emily Elizabeth Reid
Filed: 27 Mar 20
Utility
Biparatopic Fr-alpha Antibodies and Immunoconjugates
23 Mar 23
The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies.
Olga AB, Neeraj Kohli, Thomas Chittenden, Julianto Setiady
Filed: 10 Jun 22
Utility
Methods of Preparing Cytotoxic Benzodiazepine Derivatives
9 Feb 23
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
Filed: 15 Jun 22
Utility
Methods of Preparing Cytotoxic Benzodiazepine Derivatives
9 Feb 23
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Michael Reardon, Richard A. Silva
Filed: 15 Jun 22
Utility
Anti-FOLR1 Immunoconjugate Dosing Regimens
1 Dec 22
Methods of administering immunoconjugates that bind to FOLR1 are provided.
Kelli Running, Robert A. Mastico, James J. O'Leary, Olga AB, Beni Wolf
Filed: 14 Apr 22
Utility
ANTI-CD123 Antibodies and Conjugates and Derivatives Thereof
24 Nov 22
The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα).
Yelena Kovtun, Daniel J. Tavares, Lingyun Rui, Thomas Chittenden
Filed: 1 Apr 22
Utility
Methods for Antibody Drug Conjugation, Purification, and Formulation
25 Aug 22
Methods of producing, purifying, and formulating antibody drug conjugates (ADCs) are provided herein.
Daniel F. MILANO, Michael R. REARDON, Richard A. SILVA, Benjamin M. HUTCHINS, Robert W. HERBST
Filed: 8 Feb 22
Utility
Methods of Preventing Methionine Oxidation In Immunoconjugates
30 Jun 22
The present invention generally relates to methods of preventing methionine oxidation in immunoconjugates.
Michael Fleming, Amit Gangar, Nicholas C. Yoder, Chen Bai, Scott A. Hilderbrand, Benjamin M. Hutchins
Filed: 13 Dec 21
Utility
Antibodies and Assays for Detection of Folate Receptor 1
2 Jun 22
The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies.
Olga AB, Daniel TAVARES, Julianto SETIADY, Sharron LADD, Christina N. CARRIGAN, Lingyun RUI
Filed: 10 Nov 21