794 patents
Utility
Synthetic Nanostructures Including Nucleic Acids and/or Other Entities
18 Jan 24
Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided.
C. Shad Thaxton, Chad A. Mirkin, Kaylin McMahon, Sushant Tripathy, Raja Kannan Mutharasan, David M. Leander, Andrea J. Luthi
Filed: 25 Aug 23
Utility
Robotic End Effector System and Method with Lockable Compliance
11 Jan 24
Robotic systems and methods are provided with an end effector having lockable compliance.
Joshua Lee Solomon, Hui-ping Wang, Lu Huang, Dalong Gao, Dohyun Leem
Filed: 5 Jul 22
Utility
3D Printing of Biomedical Implants
11 Jan 24
Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants.
Jian Yang, Evan C. Baker, Henry O. T. Ware, Fan Zhou, Cheng Sun, Guillermo A. Ameer, Robert Van Lith
Filed: 31 Jan 23
Utility
Single Reactor Chain Shuttling Reactions for Ethylene/Vinylarene Multiblock Interpolymers
11 Jan 24
Evelyn Auyeung, Rhett A. Baillie, Thomas Wesley Karjala, JR., Zhe Zhou, Jeffrey C. Munro, Colin Li Pi Shan, Phillip D. Hustad, Tobin J. Marks, Yanshan Gao
Filed: 16 Dec 21
Utility
METHODS FOR FULL-LENGTH REVERSE TRANSCRIPTION PCR OF LONG RNAs CONTAINING MODIFIED RIBONUCLEOSIDES USING A THERMOSTABLE REVERSE TRANSCRIPTASE
11 Jan 24
Disclosed are methods, components, compositions, and kits for preparing DNA molecules by reverse transcribing RNA templates that comprise modified ribonucleosides.
Michael C. Jewett, Michael J. Hammerling
Filed: 2 Nov 21
Utility
Advanced Mechano-acoustic Sensing and Applications of Same
4 Jan 24
This invention discloses an electronic device for measuring physiological parameters of a living subject including at least a first inertial measurement unit (IMU) and a second IMU, the first IMU and the second IMU are time-synchronized to and spatially and mechanically separated from each other; and a microcontroller unit (MCU) electronically coupled to the first IMU and the second IMU for processing of data streams from the first IMU and the second IMU.
Shuai Xu, Hyoyoung Jeong, Jong Yoon Lee, Kun Hyuck Lee, John A. Rogers
Filed: 2 Nov 21
Utility
Methods and Materials for Matching Chemistry of Individuals and Human Melanin
4 Jan 24
Aspects disclosed herein include a method for matching hair composition, the method comprising: characterizing one or more first characteristics of a natural melanin composition of a hair sample from a subject; and preparing a prepared artificial melanin formulation to approximate (or, to match or to resemble) the one or more first characteristics; wherein the prepared artificial melanin formulation comprises one or more artificial melanin materials.
Nathan C. GIANNESCHI, Zofia Elzbieta SIWICKA, Wei CAO
Filed: 28 Jun 23
Utility
Methods for Enhancing Cytotoxic Cancer Therapy Through Modulation of Purine Biosynthesis Pathways
4 Jan 24
Disclosed are methods and compositions for treating proliferative cell diseases and disorders such as cancers.
Atique U. Ahmed, Jack M. Shireman, Cheol H. Park
Filed: 15 Sep 23
Utility
Methods and Genomic Classifiers for Identifying Homologous Recombination Deficiency Prostate Cancer
4 Jan 24
The disclosure relates to methods, systems, kits and probe sets for the identification, determination, diagnosis, and/or prognosis of homologous recombination deficiency prostate cancer in a subject.
Edward Matthew Schaeffer, Elai Davicioni, Yang Liu, Adam Benjamin Weiner
Filed: 18 Nov 21
Utility
Treated Dried Blood Sample for Detection of Heavy Metals In Dried Blood
4 Jan 24
The present invention provides methods, compositions, kits, and devices for detecting heavy metals in dried blood (e.g., dried blood spots).
William E. Funk, Thomas McDade
Filed: 18 Sep 23
Utility
Hydrophobic Drugs In Organic Core High Density Lipoprotein (HDL) Nanoparticles
28 Dec 23
Disclosed herein are high-density lipoprotein-like nanoparticles (HDL-NP) having a soft material core (e.g., a lipid-conjugated inorganic core) associated with hydrophobic therapeutic agents.
Stephen E. Henrich, Jonathan S. Rink, Adam Y. Lin, C. Shad Thaxton, Leo I. Gordon, Sonbinh T. Nguyen, Steven T. Rosen, David Horne, Xu Hannah Zhang
Filed: 22 Oct 21
Utility
Ion-based Methods for Stabilizing and Improving Porous Metal-organic Framework (Mof) Materials for Water Harvesting from Air and Related Applications
28 Dec 23
Metal Organic Frameworks (MOFs), methods of using the MOFs for harvesting water from air, and methods of making the MOFs are provided.
Joseph T. Hupp, Jian Liu, Zhiyong Lu
Filed: 9 Nov 21
Utility
Hierarchical Nanoporous Diamondoid Superstructure
28 Dec 23
Disclosed herein are compositions, supramolecular assemblies, crystalline compositions, and methods of making and using the same.
Qing-Hui Guo, James Fraser Stoddart
Filed: 12 Sep 23
Utility
Systems and Methods for Quantifying Patient Improvement Through Artificial Intelligence
28 Dec 23
Examples of a system and methods for quantifying patient improvement via artificial intelligence are disclosed.
Stephen A. Antos, Konrad P. Kording, Vivek Sagar
Filed: 31 Jan 22
Utility
Systems and Methods for Dieless Composite Forming
21 Dec 23
Knitmorphs and methods of knitmophing include knitting one or more yarn materials into knitted structure having a first shape.
Sangram Keshari Rout, Jian Cao, Marisa Ravena Bisram
Filed: 14 Apr 23
Utility
Melanin Hair Dye with Thickeners
21 Dec 23
Included herein are methods and materials for nontoxic, biocompatible, optionally metal-free, tunable, and long-lasting coloration of human hair.
Nathan C. GIANNESCHI, Zofia Elzbieta SIWICKA
Filed: 21 Jun 23
Utility
Terlipressin-octadecanedioic Acid Conjugate for Vasoconstrictive Therapy
14 Dec 23
In an aspect, disclosed herein is a compound characterized by formula (FX1): A1-X1—X2-A2 (FX1); wherein: A1 is a carboxylic acid group, a carboxylate anion, or a carboxylate ester, X1 is a substituted or unsubstituted and saturated or unsaturated C1-C50 aliphatic group; X2 is a linker group selected from the group consisting of a direct bond, an organic group, -0-, —S—, —S(═O)—, —S(═O)2—, —S—S—, —N═, ═N—, —N(H)—, —N═N—N(H)—, —N(H)—N═N—, —N(OH)—, —N(═O)—, and any combination thereof; and A2 is a peptide, the peptide being terlipressin or a substituted or unsubstituted derivative, a substituted or unsubstituted natural or synthetic analogue, a substituted or unsubstituted variant, a substituted or unsubstituted isomer, or a substituted or unsubstituted fragment of terlipressin.
Or BERGER, Wonmin CHOI, Nathan C. GIANNESCHI, Daniel BATLLE
Filed: 17 Dec 20
Utility
Wireless Probes for Monitoring Blood Flow In Biological Tissue
14 Dec 23
A wearable probe includes a sensor module and a control module.
Mitchell Pet, Matthew MacEwan, John Rogers, Changsheng Wu, Di Lu, Wubin Bai, Hexia Guo, Shuo Li, Hany Arafa
Filed: 22 Oct 21
Utility
Use of Nucleotide Synthesis Inhibitors for Targeted Therapy In MLL3/4 Compass Mutant Cancer
7 Dec 23
Disclosed herein are methods and compositions for treating a subject comprising the administration of an effective amount of a nucleotide synthesis inhibitor to a subject in need of treatment for a MLL3/4 COMPASS deficient cancer or a MLL3/4 loss of function mutation.
Ali Shilatifard, Zibo Zhao
Filed: 2 Jun 23
Utility
Use of Reelin for Treating Cardiac Diseases
7 Dec 23
Disclosed herein are compositions and methods useful for treating diseases, conditions and injuries of the heart, and/or improving cardiac function in a subject in need thereof.
Guillermo Oliver, Xiaolei Liu
Filed: 14 Oct 21