283 patents
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
18 Jan 24
Jason MCCARTNEY, Alexander Russell ABELA, Sunny ABRAHAM, Corey Don ANDERSON, Vijayalaksmi ARUMUGAM, Jaclyn CHAU, Jeremy CLEMENS, Thomas CLEVELAND, Timothy Richard COON, Andrew DINH, Timothy A. DWIGHT, Lev Tyler Dewey FANNING, Bryan A. FRIEMAN, Peter GROOTENHUIS, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Paul KRENITSKY, Mark Thomas MILLER, Fabrice PIERRE, Alina SILINA, Joe A. TRAN, Lino VALDEZ, Jinglan ZHOU
Filed: 6 Oct 21
Utility
Nucleic Acid Encoding Modified Membrane Type Serine Protease 1 (MTSP-1) Polypeptides and Methods of Use
18 Jan 24
Provided are MTSP-1 polypeptides modified to have altered activity and/or specificity so that they cleave a complement protein, such as complement protein C3, to inhibit its activity and thereby inhibit complement activation.
Edwin L. MADISON, Vanessa Soros, Mikhail Popkov
Filed: 16 Aug 23
Utility
Crystalline forms of CFTR modulators
16 Jan 24
Yi Shi, Kevin J. Gagnon, Jicong Li, Jennifer Lu, Ales Medek, Muna Shrestha, Michael Waldo, Beili Zhang, Carl L. Zwicker, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou
Filed: 13 Aug 20
Utility
Methods of Monitoring ALPHA-1 Antitrypsin (Aat) Deficiency by Measuring Polymerised Aat
11 Jan 24
This application describes methods of measuring AAT polymer and kits for use in the same.
Marina Simeone PENNEY, Christi D. COOK
Filed: 11 Nov 21
Utility
Inhibitors of APOL1 and methods of using same
9 Jan 24
Jun Myun Ahn, Samantha Angle, Michael Aaron Brodney, Jingrong Cao, John E. Cochran, Jon H. Come, Leslie A. Dakin, Elena Dolgikh, Brad D. Maxwell, Suganthini S. Nanthakumar, Hardwin O'Dowd, Jessica Howard Olsen, Timothy J. Senter, Akira Joseph Shimizu, Steven David Stone, Haoxuan Wang
Filed: 26 Aug 21
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators
9 Jan 24
Jeremy J. Clemens, Alexander Russell Abela, Corey Don Anderson, Brett B. Busch, Weichao George Chen, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Senait G. Ghirmai, Peter Grootenhuis, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Ping Kang, Haripada Khatuya, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Andreas Termin, Johnny Uy, Carl V. Vogel, Jinglan Zhou
Filed: 18 May 21
Utility
Solid Forms of 4-(5-(4-FLUOROPHENYL)-6-(TETRAHYDRO-2H-PYRAN-4-YL)-1,5-DIHYDROPYRROLO[2,3-F]INDAZOL-7-YL)BENZOIC Acid
4 Jan 24
Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD).
Yi SHI, Mei-Hsiu LAI, Ales MEDEK, Kan-Nian HU, Zhengtian SONG, Elisa A. TORRICO GUZMAN, Kathleen Paige SOKOLOWSKY, Simon GIROUX, Siying LIU, Kirk Alan OVERHOFF, Setu RODAY, Rupa SAWANT, Marisa SPOSATO
Filed: 17 Nov 21
Utility
Compositions and Methods for Treatment of DM1 with SLUCAS9 and SACAS9
28 Dec 23
Compositions and methods for treating myotonic dystrophy type 1 (DM1) with SluCas9 and SaCas9 are encompassed.
John Patrick Leonard, Zachary Michael Detwiler, Peter Thomas Hallock, Eric Gunnar Anderson
Filed: 5 Nov 21
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
28 Dec 23
Jason MCCARTNEY, Alexander Russell ABELA, Sunny ABRAHAM, Corey Don ANDERSON, Vijayalaksmi ARUMUGAM, Jaclyn CHAU, Jeremy CLEMENS, Thomas CLEVELAND, Timothy A. DWIGHT, Bryan A. FRIEMAN, Peter GROOTENHUIS, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Mark Thomas MILLER, Alina SILINA, Jinglan ZHOU
Filed: 6 Oct 21
Utility
Process of Making CFTR Modulators
14 Dec 23
Paul Angell, John E. Cochran, Benjamin J. Littler, David Siesel, Armando Urbina, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou
Filed: 4 Jan 23
Utility
Macroencapsulation Devices
7 Dec 23
A method of manufacturing a macroencapsulation device includes aligning one or more membranes of the device with a frame of the device, such that a portion of the one or more membranes overlap a portion of the frame.
Christopher Thanos, Megan Billings, Matthew Watson
Filed: 6 Jun 23
Utility
Substituted tetrahydrofurans as modulators of sodium channels
5 Dec 23
Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided.
Steven John Durrant, Nadia Ahmad, Elizabeth Mary Beck, Lidio Marx Carvalho Meireles, Ewa Iwona Chudyk, Gorka Etxebarria Jardi, Bhairavi Galan, Sara S. Hadida Ruah, Dennis James Hurley, Ronald Marcellus Knegtel, Timothy Donald Neubert, Joanne Louise Pinder, Joseph Pontillo, Robert Pullin, Yvonne Schmidt, David Matthew Shaw, Sarah Skerratt, Dean Stamos, Stephen Andrew Thomson, Anisa Nizarali Virani, Christopher Wray
Filed: 4 Dec 20
Utility
Heteroaryl Compounds for the Treatment of Pain
30 Nov 23
Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided.
Mark Thomas Miller, Dennis James Hurley, Timothy Donald Neubert, Elamprakash Nesan Savariar, Urvi Patel, Sara Sabina Hadida Ruah, Jason McCartney, Jinglan Zhou, Robert Martin Demoret, Roman Askatovich Valiulin, Alexander Frederik Kintzer, Peter Webb, David Robert Slochower, Kathleen Aertgeerts, Elizabeth Mary Beck, Ronald Marcellus Alphonsus Knegtel, Ewa Iwona Chudyk, Joanne Louise Pinder
Filed: 21 Apr 23
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
30 Nov 23
Jason MCCARTNEY, Alexander Russell ABELA, Sunny ABRAHAM, Corey Don ANDERSON, Vijayalaksmi ARUMUGAM, Jaclyn CHAU, Jeremy CLEMENS, Thomas CLEVELAND, Timothy A. DWIGHT, Bryan A. FRIEMAN, Peter GROOTENHUIS, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Paul KRENITSKY, Mark Thomas MILLER, Fabrice PIERRE, Alina SILINA, Johnny UY, Jinglan Zhou
Filed: 6 Oct 21
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
30 Nov 23
Jason MCCARTNEY, Alexander Russell ABELA, Sunny ABRAHAM, Corey Don ANDERSON, Vijayalaksmi ARUMUGAM, Jaclyn CHAU, Jeremy CLEMENS, Thomas CLEVELAND, Timothy Richard COON, Timothy A. DWIGHT, Lev Tyler Dewey FANNING, Bryan A. FRIEMAN, Peter GROOTENHUIS, Anton V. GULEVICH, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Haripada KHATUYA, Paul KRENITSKY, Vito MELILLO, Mark Thomas MILLER, Prasuna PARASELLI, Fabrice PIERRE, Alina SILINA, Joe A. TRAN, Johnny UY, Lino VALDEZ, Jinglan ZHOU
Filed: 6 Oct 21
Utility
N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
28 Nov 23
Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided.
Elizabeth Mary Beck, Steven John Durrant, Sarah Skerratt, Robert Pullin, Gorka Etxebarria Jardi, David Matthew Shaw, Nadia M. Ahmad, Christopher Wray, Anisa Nizarali Virani, Kiri North, James Dodd, Michael Edward O'Donnell, Bhairavi Galan, Ronald Marcellus Knegtel, Ewa Iwona Chudyk, Joanne Louise Pinder, Stephen Andrew Thomson, Lidio Marx Carvalho Meireles, Dean Stamos, Yvonne Schmidt, Joseph Pontillo, Sara S. Hadida Ruah, Timothy Donald Neubert, Dennis James Hurley, Jinglan Zhou
Filed: 3 Jun 22
Utility
Heteroaryl Compounds for the Treatment of Pain
23 Nov 23
Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided.
Mark Thomas Miller, Dennis James Hurley, Timothy Donald Neubert, Vijayalaksmi Arumugam, Sara Sabina Hadida Ruah, Jason McCartney, Jinglan ZHOU, Jaclyn Chau, Robert Martin Demoret, Senait G. Ghirmai, Roman Askatovich Valiulin, Alexander Frederik Kintzer, David Robert Slochower, Kathleen Aertgeerts, Elizabeth Mary Beck, James Jun Bon Mui, Miranda Adele Wright, Ronald Marcellus Alphonsus Knegtel, Ewa Iwona Chudyk, Joanne Louise Pinder, James Dodd
Filed: 21 Apr 23
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
23 Nov 23
Jason MCCARTNEY, Sunny ABRAHAM, Corey Don ANDERSON, Vijayalaksmi ARUMUGAM, Jaclyn CHAU, Thomas CLEVELAND, Timothy A. DWIGHT, Bryan A. FRIEMAN, Peter GROOTENHUIS, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Mark Thomas MILLER, Alina SILINA, Jinglan ZHOU
Filed: 6 Oct 21
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
23 Nov 23
Jason MCCARTNEY, Sunny ABRAHAM, Corey Don ANDERSON, Vijayalaksmi ARUMUGAM, Jaclyn CHAU, Thomas CLEVELAND, Timothy A. DWIGHT, Bryan A. FRIEMAN, Peter GROOTENHUIS, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Mark Thomas MILLER, Alina SILINA, Jinglan ZHOU
Filed: 6 Oct 21
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
23 Nov 23
Jason MCCARTNEY, Sunny ABRAHAM, Corey Don ANDERSON, Vijayalaksmi ARUMUGAM, Jaclyn CHAU, Thomas CLEVELAND, Timothy A. DWIGHT, Bryan A. FRIEMAN, Peter GROOTENHUIS, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Mark Thomas MILLER, Alina SILINA, Jinglan ZHOU
Filed: 6 Oct 21