52 patents
Utility
Modified Release Formulations and Uses Thereof
21 Dec 23
Provided are modified release compositions in a solid oral dosage form comprising amisulpride in the form of an unequal mixture of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens.
Takumi Asada, Gerald R. Galluppi, Seth Cabot Hopkins, Megumi Maruyama, Siriporn Toongsuwan, Yuki Tsushima
Filed: 7 Mar 23
Utility
Nonracemic Mixtures and Uses Thereof
14 Sep 23
Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens.
Seth Cabot Hopkins, Kenneth Stephen Koblan, John R. Snoonian, Harold Scott Wilkinson
Filed: 31 Oct 22
Utility
Methods of Treating Metabolic Disorders
3 Aug 23
Linda Jane BRISTOW, Nina DEDIC, Eva HAJOS-KORCSOK, Seth Cabot HOPKINS, Philip Glyn JONES, Kenneth S. KOBLAN, Snezana MILANOVIC, Colleen Marie SYNAN, Kuangnan XIONG
Filed: 21 Sep 22
Utility
Crystal Forms and Production Methods Thereof
9 Mar 23
The various aspects present inventions provide various crystalline forms of (S)-(−)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same.
John R. Snoonian, Harold Scott Wilkinson, Haitao Zhang
Filed: 19 May 22
Utility
Salts, Crystal Forms, and Production Methods Thereof
22 Dec 22
Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same.
Andrea BAUER, Nandkumar Nivritti BHOGLE, Xiaoxia CHEN, Shahla JAMZAD, Robert Joseph PRYTKO, Kostas SARANTEAS, Michael Joseph SIZENSKY, Harold Scott WILKINSON, Haitao ZHANG
Filed: 22 Jul 22
Utility
Multicyclic Compounds and Methods of Use Thereof
8 Dec 22
Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use.
Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
Filed: 13 Jan 22
Utility
Nebulizer Monitoring Device, System and Method
27 Oct 22
Described herein are devices, systems and methods for monitoring the use of a nebulized medication, such as can be administered using a nebulizer.
Michael Segal, Nathan Arian Abel, Spencer Brown, Everett Crosland, Francisco Javier de Ana Arbeloa, Thomas Goodin, Joseph Gordon, Michael Metz, Daniel James Nelson, Jae Hong Park, Sean Scanlon, Janis Paulis Skujins, Jennet Toyjanova
Filed: 8 Jul 22
Utility
Compounds and Compositions and Uses Thereof
27 Oct 22
Linghong XIE, Michele L.R. HEFFERNAN, Philip Glyn JONES, Taleen G. HANANIA
Filed: 11 Jan 21
Utility
Modified Release Formulations and Uses Thereof
13 Oct 22
Provided are modified release compositions in a solid oral dosage form comprising racemic amisulpride, or pharmaceutically acceptable salts thereof, and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens.
Takumi ASADA, Gerald R. GALLUPPI, Seth Cabot HOPKINS, Megumi MARUYAMA, Siriporn TOONGSUWAN, Yuki TSUSHIMA
Filed: 4 Jun 20
Utility
Child-resistant Dispensers for Thin Strip Medications
4 Aug 22
Product containers, especially child-resistant product dispensers, and methods of use thereof.
Thierry BILBAULT, Arthur TONG
Filed: 26 Jun 20
Utility
1-HETEROCYCLYL Isochromanyl Compounds and Analogs for Treating CNS Disorders
16 Jun 22
Linghong XIE, Philip Glyn JONES, Kerry L. SPEAR, Noel Aaron POWELL, Taleen G. HANANIA, Vadim ALEXANDROV
Filed: 29 Oct 21
Utility
Child Resistant Peel Pouch
26 May 22
Disclosed are packages for dispensing a product, the package including: a first layer; a second layer; a tab seal zone in which the first layer is joined to the second layer by a seal, the tab seal zone defining a first tab and a second tab; a first perforation in the first layer and a second perforation in the second layer, the first perforation defining a tear path in the first layer and the second perforation defining a tear path in the second layer, wherein at least one of the first and second perforations at least partially defines a boundary separating the first tab and the second tab; and a fold guide located in the tab seal zone, the fold guide indicating a fold line that intersects the first perforation and the second perforation across the boundary separating the first tab and the second tab.
Julie A. CARDIN, Edward Emmett CHAPDELAINE
Filed: 12 Mar 20
Utility
Modified Release Formulations and Uses Thereof
21 Apr 22
Provided are modified release compositions in a solid oral dosage form comprising amisulpride in the form of an unequal mixture of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens.
Takumi Asada, Gerald R. Galluppi, Seth Cabot Hopkins, Megumi Maruyama, Siriporn Toongsuwan, Yuki Tsushima
Filed: 30 Sep 21
Utility
Salts of a Heterocyclic Compound and Crystalline Forms, Processes for Preparing, Therapeutic Uses, and Pharmaceutical Compositions Thereof
31 Mar 22
The present disclosure relates to salts of (R)-1-(8-fluoroisochroman-1-yl)-N-methylmethanamine, crystalline forms thereof, and methods of preparation thereof, which are useful in the treatment of CNS disorders.
Nandkumar Nivritti BHOGLE, Takahiko HASHIZUKA, Robert Joseph PRYTKO, John R. SNOONIAN, Harold Scott WILKINSON, Haitao ZHANG
Filed: 15 Jun 21
Utility
Methods of Treating Schizophrenia
3 Mar 22
Provided herein are methods for determining if a compound has potential efficacy for the treatment for a specific symptom domain of schizophrenia, such as for example, the treatment of a negative symptom of schizophrenia.
Seth Hopkins, Kenneth Koblan, Antony Loebel, Ajay Ogirala
Filed: 6 Apr 21
Utility
Methods of Treating Central Nervous System Disorders
16 Dec 21
Provided herein are methods of treating central nervous system (CNS) disorders (e.g., Binge Eating Disorder (BED), Attention-Deficit/Hyperactivity Disorder (ADHD), etc.) with a dasotraline therapy while avoiding adverse drug interactions.
Jing LIN
Filed: 30 Oct 19
Utility
Sublingual Apomorphine
21 Oct 21
The invention features sublingual formulations of apomorphine and apomorphine prodrugs, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.
Anthony John GIOVINAZZO, David Bruce HEDDEN, Marc L. DE SOMER, Nathan John BRYSON
Filed: 26 Feb 21
Utility
Methods of Treating Neurological and Psychiatric Disorders
14 Oct 21
Carrie A. BOWEN, Seth Cabot HOPKINS, Colleen M. SYNAN
Filed: 13 Apr 21
Utility
Nonracemic Mixtures and Uses Thereof
14 Oct 21
Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens.
Seth Cabot Hopkins, Kenneth Stephen Koblan, John R. Snoonian, Harold Scott Wilkinson
Filed: 13 Nov 20
Utility
Methods of Treating a Patient Having Parkinson's Disease
14 Oct 21
Methods of treating a patient having Parkinson's disease, including treating “OFF” episodes and improving motor function, by administering apomorphine or a pharmaceutically acceptable salt thereof are disclosed herein.
Thierry BILBAULT, Bradford Armando NAVIA, Charles Warren OLANOW
Filed: 10 Jun 21