15 patents
Utility
Compositions and methods for treatment of diabetic macular edema
29 Jun 21
Disclosed herein are compositions comprising one or more antibodies that specifically bind active plasma kallikrein (e.g., human plasma kallikrein) and methods of using such compositions for the treatment of retinal diseases, such as diabetic macular edema.
Gregory P. Conley, Andrew Nixon, Daniel J. Sexton
Filed: 15 Aug 19
Utility
Nucleic acids encoding anti-neonatal Fc receptor (FcRn) antibodies
25 May 21
The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
Daniel J. Sexton, Christopher TenHoor, Malini Viswanathan
Filed: 7 Oct 19
Utility
Monoclonal antibody inhibitor of factor XIIA
9 Feb 21
Disclosed herein are anti-Factor XIIa antibodies and methods of using such for treating diseases associated with Factor XII, including diseases associated with contact system activation, plasma prekallikrein signaling (e.g., hereditary angioedema), and ocular diseases.
Shauna Mason, Jon A. Kenniston, Andrew Nixon, Daniel J. Sexton, Stephen R. Comeau, Burt Adelman
Filed: 21 Jul 16
Utility
Immunoassay to detect cleaved high molecular weight kininogen
9 Feb 21
The present disclosure provides immunoassay methods of detecting a cleaved high molecular weight kininogen (HMWK) with high sensitivity and specificity and isolated antibodies that specifically bind cleaved HMWK.
Daniel J. Sexton, Ryan Faucette, Janja Cosic
Filed: 19 Oct 16
Utility
Evacuated blood collection tubes containing protease inhibitors for the assessment of contact system activation
21 Dec 20
Disclosed herein are evacuated blood collection tubes comprising protease inhibitor cocktails in liquid form and uses thereof for assessing features associated with the contact system in a subject, including the endogenous level of contact system activation, the endogenous level of a drug that targets a component of contact system during treatment, and/or the immunogenicity of such a drug.
Daniel J. Sexton, Ryan Faucette
Filed: 11 Aug 16
Utility
Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
9 Nov 20
Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods.
Robert Charles Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
Filed: 1 Jun 17
Utility
Libraries of genetic packages comprising novel HC CDR3 designs
20 Jul 20
Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme.
Robert Charles Ladner
Filed: 7 Dec 17
Utility
Assays for determining levels of plasma protease C1 inhibitor
22 Jun 20
The invention provides assay methods of detecting plasma protease CI inhibitor (Cl-INH) that binds plasma kallikrein, Factor XII, or both, and uses thereof for identifying subjects at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder.
Kusumam Joseph, Allen P. Kaplan
Filed: 16 Jan 14
Utility
Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs
15 Jun 20
Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme.
Robert Charles Ladner
Filed: 7 Jun 16
Utility
Diagnosis and treatment of autoimmune diseases
11 May 20
Methods, kits and compositions for diagnosing and treating autoimmue diseases such as rheumatiodi arthritis, Crohn's disease, and ulcerative colitis.
Daniel J. Sexton, Burt Adelman, Andrew Nixon
Filed: 13 Sep 18
Utility
Focused libraries of genetic packages
30 Mar 20
Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family.
Robert Charles Ladner
Filed: 29 Oct 17
Utility
Display library process
2 Mar 20
Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries.
Robert Charles Ladner, Shannon Hogan, Kristin L. Rookey
Filed: 25 May 17
Utility
Multi-chain eukaryotic display vectors and uses thereof
2 Mar 20
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is exhibited at the surface of the host cell.
Simon E. Hufton, Hendricus Renerus Jacobus Mattheus Hoogenboom
Filed: 22 Jul 18
Utility
Fc receptor antibodies and methods of use thereof
18 Nov 19
The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
Daniel J. Sexton, Christopher TenHoor, Malini Viswanathan
Filed: 3 Dec 17
Utility
Compositions and methods for treatment of diabetic macular edema
30 Sep 19
Disclosed herein are compositions comprising one or more antibodies that specifically bind active plasma kallikrein (e.g., human plasma kallikrein) and methods of using such compositions for the treatment of retinal diseases, such as diabetic macular edema.
Gregory P. Conley, Andrew Nixon, Daniel J. Sexton
Filed: 25 Mar 15
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