1002 patents
Utility
Removable Ion Source Capable Of Axial Or Cross Beam Ionization
18 Jan 24
An ion source including an ionization assembly, first and second electron sources, and a magnet assembly.
Edward B. McCauley, Dustin Donald Holden
Filed: 19 Nov 21
Utility
System and Method for Preparation and Delivery of Biological Samples for Charged Particle Analysis
18 Jan 24
Systems and method for the preparation and delivery of biological samples for charged particle analysis are disclosed herein.
Marcus STRAW, Dmitry GRINFELD, Alexander MAKAROV, Alan BAHM, Aaron TOROK, Kun LIU, Joseph CHRISTIAN, Josh GILBERT, Tom NICHOLS, Jeff KOSMOSKI
Filed: 18 Jul 23
Utility
Inert Non-adsorbing Crimpable Capillaries and Devices for Adjusting Gas Flow In Isotope Ratio Analysis
18 Jan 24
A gas transfer system for transferring gas into an analytical instrument for isotope ratio analysis comprises a capillary for delivering sample and/or reference gas from a gas source, a first connector for connecting the capillary to the gas source, a second connector for connecting the capillary to the analytical instrument, a crimping device, wherein the internal surface of the capillary comprises a coating material to prevent or minimize adsorption of water to the surface.
Michael KRUMMEN, Jens RADKE, Johannes SCHWIETERS, Nils STÖEBENER, Ronald SEEDORF
Filed: 25 Sep 23
Utility
Systems and Methods for Identifying Sequence Variation
18 Jan 24
Systems and method for determining variants can receive mapped reads, and call variants.
Fiona HYLAND, Eric TSUNG, Vasisht TADIGOTLA, Zheng ZHANG, Dumitru BRINZA, Onur SAKARYA, Xing XU
Filed: 7 Jun 23
Utility
Processing Ion Peak Areas In Mass Spectrometry
11 Jan 24
A method of analysing a signal generated by a mass analyser comprises receiving a signal generated by the mass analyser, determining the area of a first ion peak of one or more ion peaks in the signal, and estimating the number of ions that contributed to the first ion peak.
Bernd Hagedorn, Daniel Mourad, Toby Shanley, Hamish Stewart, Ankit Dwivedi
Filed: 6 Jul 23
Utility
Retaining Ring for a Centrifuge
11 Jan 24
A retaining ring arrangement for a centrifuge rotor of a centrifuge, comprising a base, having a planar portion with an aperture centrally therethrough, the base further having a perimeter wall extending upwardly from the planar portion to define a cavity bounded by the planar portion and the perimeter wall.
Benoit Jean LIMON
Filed: 6 Jul 23
Utility
Biotin Derivatives
11 Jan 24
Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.
Lai-Qiang YING, Stephen YUE, Bruce BRANCHAUD, Yu-Zhong ZHANG
Filed: 10 Jul 23
Utility
Cycle Timer for Improved Purity of Reagent Gas Systems
11 Jan 24
A system including a gas source coupled to a mass spectrometer with a supply line to provide reagent gas for chemical ionization; a bypass line connecting the supply line to a foreline of a vacuum pump, the bypass line including a valve and a bypass restrictor; and a cycle timer operable to open the valve for a first period of time and close the valve for a second period of time.
Edward B. McCAULEY
Filed: 15 Jun 23
Utility
Charged Particle Beam Device for Inspection of a Specimen with a Plurality of Charged Particle Beamlets
4 Jan 24
The invention relates to a charged particle beam device for inspection of a specimen with a plurality of charged particle beamlets.
Ali Mohammadi-Gheidari, Erik René Kieft, Pieter Kruit
Filed: 26 Jul 22
Utility
Lipid Compositions For In Vivo Delivery
4 Jan 24
Provided herein, are compositions, methods and kits for inducing an immune response in a subject.
Evgenia VEROVSKAYA, Joel JESSEE
Filed: 29 Jun 23
Utility
Switchable-path Ion Guide
4 Jan 24
An ion guide with a switchable ion path for a spectrometer includes a first ion transport aperture configured to receive an ion beam.
Hamish Stewart
Filed: 28 Jun 23
Utility
Enzymatic Ligation of Nucleic Acids
4 Jan 24
Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein.
Stephen HENDRICKS, David J. KING
Filed: 20 Apr 23
Utility
Systems and Methods for Annotating Biomolecule Data
4 Jan 24
Systems, methods, software and computer-usable media for annotating biomolecule-related data are disclosed.
Liviu POPESCU, Flona HYLAND
Filed: 21 Jun 23
Utility
Methods for Assessing Genomic Instability
4 Jan 24
Methods for assessing genomic instability (GI) may include selectively amplifying nucleic acid sequences at targeted locations in a tumor sample genome by a targeted panel with a low sample input to generate a plurality of nucleic acid sequence reads; dividing the genome into segments having homogeneous copy numbers using log odds of heterozygous SNPs and CNV log ratios determined for the nucleic acid sequence reads; applying a threshold count to squared allelic log odds of each segment in autosomes of the genome to identify unbalanced copy number (UCN) segments; adding numbers of bases in the UCN segments to produce a sum of UCN bases; and dividing the sum of UCN bases by the total number of bases in all the segments identified in the autosomes of the sample genome to produce a ratio indicative of genomic instability.
Mohit GUPTA
Filed: 29 Jun 23
Utility
Compositions and Methods for Immune Repertoire Monitoring
28 Dec 23
The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire.
Geoffrey Lowman, Chenchen Yang, Timothy Looney
Filed: 15 May 23
Utility
Ultra-high-speed Rotor
28 Dec 23
A rotor (10) for use in a centrifuge includes a rotor body (12), a drive hub (20), and a balance ring (16, 160).
Sina PIRAMOON
Filed: 27 Oct 21
Utility
Combined Laser and Broad Ion Beam (Bib) Systems for More Efficient Processing of Multiple Samples
28 Dec 23
Systems and methods for operating a combined laser and broad ion beam (BIB) polisher in a sample preparation workflow, are disclosed.
Krishna Kanth NEELISETTY, Petr WANDROL, Ondrej KLVAC, Yakub FAM, Libor NOVAK, Michal HROUZEK
Filed: 19 May 22
Utility
Methods and Apparatus for Processing Fluids
28 Dec 23
A method for processing a fluid includes removably securing a retention member to a vessel that bounds a chamber; inserting a collapsible bag within the chamber of the vessel; securing the bag to the retention member so that the bag is supported within the chamber of the vessel; and dispensing a fluid into a compartment of the collapsible bag supported within the chamber of the vessel.
Michael E. Goodwin, Jacob D. Lee, Whitt F. Woods, Patrick L. Draper
Filed: 12 Sep 23
Utility
Focused Ion Beam System and Method
28 Dec 23
An ion beam system for modifying a sample or workpiece surface, comprises: an ion source for generating ions; an ion beam focusing column configured to direct ions from the ion source to form an ion beam and focus the ion beam towards a target area; and a sample stage for receiving and positioning the sample or workpiece at the target area, wherein the ion beam focusing column comprises: an aperture plate having a non-circular beam limiting aperture configured to limit the extent of a transmitted ion beam; and a multipole aberration compensator configured to apply a four-fold astigmatism to the ion beam to compensate spherical aberration produced by one or more lenses in the ion beam focusing column.
Alexander HENSTRA, Galen GLEDHILL
Filed: 22 Jun 23
Utility
Apparatuses, Systems And Methods For Imaging Flow Cytometry
28 Dec 23
The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.
Gregory Kaduchak, Michael Ward
Filed: 8 Sep 23